Oscillatory brain activity associates with neuroligin-3 expression and predicts progression free survival in patients with diffuse glioma

Derks, Jolanda; Wesseling, Pieter; Carbo, Ellen W. S.; Hillebrand, Arjan; Dellen, Edwin van; Hamer, Philip C. De Witt; Klein, Martin; Schenk, Geert J.; Geurts, Jeroen J. G.; Reijneveld, Jaap C.; Douw, Linda

doi:10.1007/s11060-018-2967-5

Cited by 35 publications

(44 citation statements)

References 38 publications

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“…Patients visiting the VUmc CCA Brain Tumor Center Amsterdam between 2010 and 2017 with suspected diffuse glioma were eligible to participate. Part of this patient cohort has been reported on before (Carbo et al, ; van Dellen et al, ; Derks et al, ). Inclusion criteria were (a) age over 17 years and (b) ability to participate in neuropsychological testing.…”

Section: Methodsmentioning

confidence: 99%

Understanding cognitive functioning in glioma patients: The relevance of IDH‐mutation status and functional connectivity

et al. 2019

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Introduction Cognitive deficits occur frequently in diffuse glioma patients, but are limitedly understood. An important marker for survival in these patients is isocitrate dehydrogenase (IDH) mutation (IDH‐mut). Patients with IDH‐mut glioma have a better prognosis but more often suffer from epilepsy than patients with IDH‐wildtype (IDH‐wt) glioma, who are generally older and more often have cognitive deficits. We investigated whether global brain functional connectivity differs between patients with IDH‐mut and IDH‐wt glioma, and whether this measure reflects variations in cognitive functioning in these subpopulations beyond the associated differences in age and presence of epilepsy. Methods We recorded magnetoencephalography and tested cognitive functioning in 54 diffuse glioma patients (31 IDH‐mut, 23 IDH‐wt). Global functional connectivity between 78 atlas regions spanning the entire cortex was calculated in two frequency bands (theta and alpha). Group differences in global functional connectivity were tested, as was their association with cognitive functioning, controlling for age, education, and presence of epilepsy. Results Patients with IDH‐wt glioma had lower functional connectivity in the alpha band than patients with IDH‐mut glioma (p = 0.040, corrected for age and presence of epilepsy). Lower alpha band functional connectivity was associated with poorer cognitive performance (p < 0.034), corrected for age, education, and presence of epilepsy. Conclusion Global functional connectivity is lower in patients with IDH‐wt diffuse glioma compared to patients with IDH‐mut diffuse glioma. Moreover, having lower functional alpha connectivity relates to poorer cognitive performance in patients with diffuse glioma, regardless of age, education, and presence of epilepsy.

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Section: Methodsmentioning

confidence: 99%

Understanding cognitive functioning in glioma patients: The relevance of IDH‐mutation status and functional connectivity

et al. 2019

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“…Finally, we examined whether our current results were driven by the patients who were previously studied in the presurgical phase of their disease [13]. We did this by dividing the cohort into two subgroups (previously/not previously included by Derks and colleagues) [13]. Cox univariate analyses were then performed in these two groups separately.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…This retrospective study cohort, which combined several datasets of patients previously reported on, consisted of de novo glioma patients who underwent tumor resection at the Brain Tumor Center Amsterdam [part of Amsterdam University Medical Center, location Vrije Universiteit (VUmc)] between 2010 and 2017 [13,14]. Inclusion criteria for these studies were (1) age over 17 years, (2) histopathologically confirmed glioma grade II or higher (as defined by the 2016 classification of the World Health Organization [1]), (3) tumor resection as part of their treatment, and (4) no history of neurologic or psychiatric disease.…”

Section: Patientsmentioning

confidence: 99%

“…We split the cohort based on whether patients had previously been analyzed or not (see Fig. 2) [13]. We did not adjust for any other predictors as this was an exploratory univariate analysis.…”

Section: Consistency Across Cohortsmentioning

confidence: 99%

“…Broadband power best correlates with neuronal spiking patterns in patients undergoing both non-invasive neurophysiological measurements as well as single-cell recordings using intracranially placed electrodes [12]. We recently reported on the association between broadband power and PFS in twenty-four newly-diagnosed glioma patients: lower preoperative broadband power predicted longer PFS [13]. While this suggests that broadband power may be a useful prognostic tool in glioma, prognosis based on information after resection might be more reliable than preoperatively measured broadband power.…”

Section: Introductionmentioning

confidence: 99%

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Postoperative oscillatory brain activity as an add-on prognostic marker in diffuse glioma

et al. 2020

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Introduction Progression-free survival (PFS) in glioma patients varies widely, even when stratifying for known predictors (i.e. age, molecular tumor subtype, presence of epilepsy, tumor grade and Karnofsky performance status). Neuronal activity has been shown to accelerate tumor growth in an animal model, suggesting that brain activity may be valuable as a PFS predictor. We investigated whether postoperative oscillatory brain activity, assessed by resting-state magnetoencephalography is of additional value when predicting PFS in glioma patients. Methods We included 27 patients with grade II-IV gliomas. Each patient's oscillatory brain activity was estimated by calculating broadband power (0.5-48 Hz) in 56 epochs of 3.27 s and averaged over 78 cortical regions of the Automated Anatomical Labeling atlas. Cox proportional hazard analysis was performed to test the predictive value of broadband power towards PFS, adjusting for known predictors by backward elimination. Results Higher broadband power predicted shorter PFS after adjusting for known prognostic factors (n = 27; HR 2.56 (95% confidence interval (CI) 1.15-5.70); p = 0.022). Post-hoc univariate analysis showed that higher broadband power also predicted shorter overall survival (OS; n = 38; HR 1.88 (95% CI 1.00-3.54); p = 0.038). Conclusions Our findings suggest that postoperative broadband power is of additional value in predicting PFS beyond already known predictors.

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Progress in cancer neuroscience

Lan,

Zou,

Wang

et al. 2023

MedComm

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Cancer of the central nervous system (CNS) can crosstalk systemically and locally in the tumor microenvironment and has become a topic of attention for tumor initiation and advancement. Recently studied neuronal and cancer interaction fundamentally altered the knowledge about glioma and metastases, indicating how cancers invade complex neuronal networks. This review systematically discussed the interactions between neurons and cancers and elucidates new therapeutic avenues. We have overviewed the current understanding of direct or indirect communications of neuronal cells with cancer and the mechanisms associated with cancer invasion. Besides, tumor‐associated neuronal dysfunction and the influence of cancer therapies on the CNS are highlighted. Furthermore, interactions between peripheral nervous system and various cancers have also been discussed separately. Intriguingly and importantly, it cannot be ignored that exosomes could mediate the “wireless communications” between nervous system and cancer. Finally, promising future strategies targeting neuronal–brain tumor interactions were reviewed. A great deal of work remains to be done to elucidate the neuroscience of cancer, and future more research should be directed toward clarifying the precise mechanisms of cancer neuroscience, which hold enormous promise to improve outcomes for a wide range of malignancies.

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Oscillatory brain activity associates with neuroligin-3 expression and predicts progression free survival in patients with diffuse glioma

Cited by 35 publications

References 38 publications

Understanding cognitive functioning in glioma patients: The relevance of IDH‐mutation status and functional connectivity

Understanding cognitive functioning in glioma patients: The relevance of IDH‐mutation status and functional connectivity

Postoperative oscillatory brain activity as an add-on prognostic marker in diffuse glioma

Progress in cancer neuroscience

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