Osificación pulmonar dendriforme asociada con fibrosis pulmonar idiopática

Trejo, Olga; Xaubet, Antoni; Marín-Arguedas, Alejandra; Torres, Antoni; Ramírez, José; Luburich, Patricio

doi:10.1016/s0300-2896(02)75247-2

Cited by 17 publications

(4 citation statements)

References 11 publications

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“…(17) There is no known treatment for the disease. (6,8) In the present case, the radiographic and anatomopathological findings were consistent with a rare form of dendriform pulmonary ossification. The accompanying diseases that were found in this patient, and which are described in the literature, were interstitial fibrosis, diabetes mellitus, and congestive heart failure.…”

Section: Discussionsupporting

confidence: 73%

“…(8) The occurrence of the same type of dendriform pulmonary ossification in two members of the same family has been observed, which suggests a strong genetic involvement in the progression of the ossification. (17) There is no known treatment for the disease.…”

Section: Discussionmentioning

confidence: 92%

“…Therefore, most of the cases have been diagnosed at autopsy. (2)(3) Since it was first described by Luschka in 1856, (4)(5)(6)(7)(8) fewer than 100 cases have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Ossificação pulmonar dendriforme

et al. 2006

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Diffuse pulmonary ossification is a rare condition of unknown pathogenesis in which mature bone is found in the pulmonary parenchyma. It is almost invariably discovered as an incidental finding at autopsy. Most commonly, it affects middle-aged men and is asymptomatic. We present the case of a 75-year-old man in which the chest X-ray showed diffuse interstitial infiltrate. Diagnosis was based on histopathological examination by open-lung biopsy, which revealed interstitial fibrosis with pulmonary ossification.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 92%

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Ossificação pulmonar dendriforme

et al. 2006

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“…However, according to the case report published we can deduce that the evolution of DPO is slow and when combined with UIP the prognosis is rather related to interstitial disease [1]. Moreover, the literature does not contain any case of spontaneous regression of the disease [12].…”

Section: Discussionmentioning

confidence: 99%

Diffuse pulmonary ossification associated with fibrosing interstitial lung disease

Alami

Amara

Haloua

et al. 2019

Respiratory Medicine Case Reports

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Diffuse pulmonary ossification (DPO) is a rare condition that presents with metaplastic mature bone formation in the pulmonary parenchyma. DPO is usually associated with cardiovascular or respiratory disease. We report a case of 75-year-old man with chronic dyspnea, cough, asthenia and low sputum production. A chest x-ray revealed reticular pulmonary infiltrates on both sides. Computed tomography (CT) revealed peripheral, basilar predominant reticular opacities with areas of subpleural cystic change, compatible with fibrosis, fine branching calcifications within areas of linear reticulations were also visible in both mid and lower zones. Based on the clinical presentation and CT results, the patient was diagnosed with diffuse pulmonary ossification associated with idiopathic pulmonary fibrosis. Despite its rarity, the radiologist must know suggest the diagnosis of DPO especially in the presence of idiopathic pulmonary fibrosis associated with linear branched calcified densities in areas of fibrosis, avoiding a surgical biopsy that is not stripped of risk.

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Disseminated dendriform pulmonary ossification associated with usual interstitial pneumonia: incidence and thin-section CT–pathologic correlation

et al. 2005

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The aim of this work was to assess the incidence of disseminated pulmonary dendriform ossification in usual interstitial pneumonia and nonspecific interstitial pneumonia, and to correlate thin-section computed tomography (CT) and histopathologic findings. We retrospectively reviewed thin-section CT and pathologic specimens of biopsy-proven usual interstitial pneumonia (75 patients, 57 men and 18 women, mean age 60 years, range 29-83 years) and nonspecific interstitial pneumonia (44 patients, 9 men and 35 women, mean age 55 years, range 20-73 years). On review of CT and histopathologic specimens, diffuse dendriform ossification was identified in five (four men and one woman, age range 41-68 years, mean 58 years) of 75 patients (6.7%) with usual interstitial pneumonia. It was not seen in any of 44 patients with nonspecific interstitial pneumonia. With thin-section CT (osteoporosis window; window width 818, level 273), disseminated dendriform pulmonary ossification was detected as multiple tiny calcifications in bibasilar subpleural lungs (100% sensitive and 100% specific when compared with histopathologic findings as the gold standard). The thin-section CT finding of multiple tiny calcifications in bibasilar subpleural lungs might be of some help in the differential diagnosis between usual interstitial pneumonia and nonspecific interstitial pneumonia, considering they were not seen in any patients with nonspecific interstitial pneumonia (0%, 0/44) in our series.

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Osificación pulmonar dendriforme asociada con fibrosis pulmonar idiopática

Cited by 17 publications

References 11 publications

Ossificação pulmonar dendriforme

Ossificação pulmonar dendriforme

Diffuse pulmonary ossification associated with fibrosing interstitial lung disease

Disseminated dendriform pulmonary ossification associated with usual interstitial pneumonia: incidence and thin-section CT–pathologic correlation

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