OsMre11 Is Required for Mitosis during Rice Growth and Development

Shen, Miaomiao; Nie, Yanshen; Chen, Yueyue; Zhang, Xiufeng; Jie, Zhao

doi:10.3390/ijms22010169

Cited by 8 publications

(5 citation statements)

References 79 publications

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“…Although the above‐described DSB recognition mechanisms have not yet been demonstrated biochemically in plants, the presence of orthologous genes and the observed sensitivity of the corresponding mutants to DNA‐damaging agents strongly suggest that plants use identical sensing mechanisms. For example, Arabidopsis rad50 and mre11 mutants do not respond to DSBs (Amiard et al., 2010), and rice ( Oryza sativa ) mre11 mutants show DNA damage accumulation (Shen et al., 2021).…”

Section: Ddr Signaling In Plantsmentioning

confidence: 99%

Cell cycle checkpoint control in response to DNA damage by environmental stresses

2021

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SUMMARY Being sessile organisms, plants are ubiquitously exposed to stresses that can affect the DNA replication process or cause DNA damage. To cope with these problems, plants utilize DNA damage response (DDR) pathways, consisting of both highly conserved and plant‐specific elements. As a part of this DDR, cell cycle checkpoint control mechanisms either pause the cell cycle, to allow DNA repair, or lead cells into differentiation or programmed cell death, to prevent the transmission of DNA errors in the organism through mitosis or to its offspring via meiosis. The two major DDR cell cycle checkpoints control either the replication process or the G2/M transition. The latter is largely overseen by the plant‐specific SOG1 transcription factor, which drives the activity of cyclin‐dependent kinase inhibitors and MYB3R proteins, which are rate limiting for the G2/M transition. By contrast, the replication checkpoint is controlled by different players, including the conserved kinase WEE1 and likely the transcriptional repressor RBR1. These checkpoint mechanisms are called upon during developmental processes, in retrograde signaling pathways, and in response to biotic and abiotic stresses, including metal toxicity, cold, salinity, and phosphate deficiency. Additionally, the recent expansion of research from Arabidopsis to other model plants has revealed species‐specific aspects of the DDR. Overall, it is becoming evidently clear that the DNA damage checkpoint mechanisms represent an important aspect of the adaptation of plants to a changing environment, hence gaining more knowledge about this topic might be helpful to increase the resilience of plants to climate change.

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Section: Ddr Signaling In Plantsmentioning

confidence: 99%

Cell cycle checkpoint control in response to DNA damage by environmental stresses

2021

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“…For example, the peak on chromosome 2 near BRASSINAZOLE RESISTANT 4 ( BZR4 ) plays an important role in brassinosteroid signaling transduction ( Bai et al., 2007 ). The distinct significant SNP, identified by only the FarnCPU model, was located in the interval of MEIOTIC RECOMBINATION 11 ( MRE11 ) which is essential for the regulation of the cell cycle and required for normal vegetative growth and development in rice ( Shen et al., 2020 ). The MLM model identified 50 significant SNPs in association with the MNVW trait.…”

Section: Resultsmentioning

confidence: 99%

Multi-model genome-wide association studies of leaf anatomical traits and vein architecture in rice

et al. 2023

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IntroductionThe anatomy of rice leaves is closely related to photosynthesis and grain yield. Therefore, exploring insight into the quantitative trait loci (QTLs) and alleles related to rice flag leaf anatomical and vein traits is vital for rice improvement.MethodsHere, we aimed to explore the genetic architecture of eight flag leaf traits using one single-locus model; mixed-linear model (MLM), and two multi-locus models; fixed and random model circulating probability unification (FarmCPU) and Bayesian information and linkage disequilibrium iteratively nested keyway (BLINK). We performed multi-model GWAS using 329 rice accessions of RDP1 with 700K single-nucleotide polymorphisms (SNPs) markers.ResultsThe phenotypic correlation results indicated that rice flag leaf thickness was strongly correlated with leaf mesophyll cells layer (ML) and thickness of both major and minor veins. All three models were able to identify several significant loci associated with the traits. MLM identified three non-synonymous SNPs near NARROW LEAF 1 (NAL1) in association with ML and the distance between minor veins (IVD) traits.DiscussionSeveral numbers of significant SNPs associated with known gene function in leaf development and yield traits were detected by multi-model GWAS performed in this study. Our findings indicate that flag leaf traits could be improved via molecular breeding and can be one of the targets in high-yield rice development.

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“…The recruitment of ATM to DSB depends on the Meiotic Recombination 11(MRE11) RADIATION SENSITIVE 50 (RAD50) Nijmegen breakage syndrome 1(NBS1) (MRN) complex ( 47 , 155 ). The processing of DSB by the MRN-complex depends on the nuclease activity of its elements, in particular MRE11, which leads to the formation of 3’ ssDNA overhangs ( 156 , 157 ). These ssDNA overhangs explain why the activation of ATR upon DSBs requires ATM and the MRN complex ( 155 , 158 ).…”

Section: Discussionmentioning

confidence: 99%

ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response

et al. 2023

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BackgroundThe plant immune response to DNA is highly self/nonself-specific. Self-DNA triggered stronger responses by early immune signals such as H2O2 formation than nonself-DNA from closely related plant species. Plants lack known DNA receptors. Therefore, we aimed to investigate whether a differential sensing of self-versus nonself DNA fragments as damage- versus pathogen-associated molecular patterns (DAMPs/PAMPs) or an activation of the DNA-damage response (DDR) represents the more promising framework to understand this phenomenon.ResultsWe treated Arabidopsis thaliana Col-0 plants with sonicated self-DNA from other individuals of the same ecotype, nonself-DNA from another A. thaliana ecotype, or nonself-DNA from broccoli. We observed a highly self/nonself-DNA-specific induction of H2O2 formation and of jasmonic acid (JA, the hormone controlling the wound response to chewing herbivores) and salicylic acid (SA, the hormone controlling systemic acquired resistance, SAR, to biotrophic pathogens). Mutant lines lacking Ataxia Telangiectasia Mutated (ATM) or ATM AND RAD3-RELATED (ATR) – the two DDR master kinases – retained the differential induction of JA in response to DNA treatments but completely failed to induce H2O2 or SA. Moreover, we observed H2O2 formation in response to in situ-damaged self-DNA from plants that had been treated with bleomycin or SA or infected with virulent bacteria Pseudomonas syringae pv. tomato DC3000 or pv. glycinea carrying effector avrRpt2, but not to DNA from H2O2-treated plants or challenged with non-virulent P. syringae pv. glycinea lacking avrRpt2.ConclusionWe conclude that both ATM and ATR are required for the complete activation of the plant immune response to extracellular DNA whereas an as-yet unknown mechanism allows for the self/nonself-differential activation of the JA-dependent wound response.

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OsMre11 Is Required for Mitosis during Rice Growth and Development

Cited by 8 publications

References 79 publications

Cell cycle checkpoint control in response to DNA damage by environmental stresses

Cell cycle checkpoint control in response to DNA damage by environmental stresses

Multi-model genome-wide association studies of leaf anatomical traits and vein architecture in rice

ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response

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