Osseointegrated implants in a patient with Papillon‐Lefèvre syndrome

Ullbro, Christer; Crossner, Claes-Göran; Lundgren, Tord M.; Stålblad, Per‐Åke; Renvert, Stefan

doi:10.1034/j.1600-051x.2000.027012951.x

Cited by 39 publications

(35 citation statements)

References 21 publications

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“…Patients wearing implant-supported overdentures should be instructed to take the dentures out at night, since candida species can lodge in the denture acrylate (van der Reijden et al, 1999). In cases with clinical manifestations of oral candidiasis, dentures should be cleaned in 0.2% chlorhexidine solution overnight or with a 1% chlorhexidine gel two times a day.…”

Section: (A) Influence Of Reduced Saliva Flow On Intra-oral Infectionsmentioning

confidence: 99%

Implants in the Medically Compromised Patient

Beikler

Flemmig

2003

Critical Reviews in Oral Biology & Medicine

111

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Dental clinicians are confronted with an increasing number of medically compromised patients who require implant surgery for their oral rehabilitation. However, there are few guidelines on dental implant therapy in this patient category, so that numerous issues regarding pre-and post-operative management remain unclear to the dental clinician. Therefore, the aim of the present review is to offer a critical evaluation of the literature and to provide the clinician with scientifically based data for implant therapy in the medically compromised patient. This review presents the current knowledge regarding the influence of the most common systemic and local diseases on the outcome of dental implant therapy, e.g., abnormalities in bone metabolism, diabetes mellitus, xerostomia, and ectodermal dysplasias. Specific pathophysiologic aspects of the above-mentioned diseases as well as their potential implications for implant success are critically appraised. In line with these implications, guidelines for pre-and post-operative management that may assist in the successful implant-supported rehabilitation of this patient category are proposed.

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Section: (A) Influence Of Reduced Saliva Flow On Intra-oral Infectionsmentioning

confidence: 99%

Implants in the Medically Compromised Patient

Beikler

Flemmig

2003

Critical Reviews in Oral Biology & Medicine

111

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“…Case studies on PLS patients in the last 25 years report contradictory findings. Several studies reported a depressed in vitro PMN chemotaxis (9,10,23,24,45,68,70,74), whereas others reported normal values (10,47,68,73). Similar conflicting results were found for phagocytosis (6,7,9,10,26,27,62,73), the capacity to kill S. aureus (6,10,54,62,70), and the production of hydrogen peroxide (2,5,6,10,42,55,62,68,71).…”

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confidence: 46%

Role of Polymorphonuclear Leukocyte-Derived Serine Proteinases in Defense againstActinobacillus actinomycetemcomitans

et al. 2006

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Periodontitis is a chronic destructive infection of the tooth-supportive tissues, which is caused by pathogenic bacteria such as Actinobacillus actinomycetemcomitans. A severe form of periodontitis is found in PapillonLefèvre syndrome (PLS), an inheritable disease caused by loss-of-function mutations in the cathepsin C gene. Recently, we demonstrated that these patients lack the activity of the polymorphonuclear leukocyte (PMN)-derived serine proteinases elastase, cathepsin G, and proteinase 3. In the present study we identified possible pathways along which serine proteinases may be involved in the defense against A. actinomycetemcomitans. Serine proteinases are capable to convert the PMN-derived hCAP-18 into LL-37, an antimicrobial peptide with activity against A. actinomycetemcomitans. We found that the PMNs of PLS patients released lower levels of LL-37. Furthermore, because of their deficiency in serine proteases, the PMNs of PLS patients were incapable of neutralizing the leukotoxin produced by this pathogen, which resulted in increased cell damage. Finally, the capacity of PMNs from PLS patients to kill A. actinomycetemcomitans in an anaerobic environment, such as that found in the periodontal pocket, seemed to be reduced. Our report demonstrates a mechanism that suggests a direct link between an inheritable defect in PMN functioning and difficulty in coping with a periodontitisassociated pathogen.

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“…The various modifications which were used during the fabrication of the complete dentures were the use of selective pressure impressions, keeping the vertical dimension of the occlusion low and the use of a monoplane and the narrow posterior teeth and a hollow maxillary denture for the upper arch [4][5][6][7][8][9]. The prosthodontic management strategy for young edentulous patients in general, must include the preservation of the alveolar ridge, preferably by using an implant prosthesis [10][11][12][13]. However, the rehabilitation by using implants could not be employed due to the financial constraints in the present case.…”

Section: Discussionmentioning

confidence: 99%

The Prosthodontic Management of a Young Edentulous Patient with the Papillon Lefevre Syndrome-A Rare Case Report

Basapogu¹

2012

JCDR

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The Papillon Lefevre syndrome is an autosomal recessive disorder which is characterized by various dermatological manifestations and periodontitis as a manifestation of a systemic disease. Its aetiopathogenesis is thought to be secondary to the mutation of the Cathepsin C gene. Various studies have shown that the immune related cells like the polymorphonuclear leucocytes and the macrophages and their precursors were affected.This report elicits about an edentulous male with this syndrome, who was treated with a modified complete denture prosthesis (hollow, maxillary, complete denture), considering his young age and low socioeconomic status.

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Osseointegrated implants in a patient with Papillon‐Lefèvre syndrome

Abstract: The use of implants could considerably enhance future therapeutic options for the severely dentally compromised patients with Papillon-Lefèvre syndrome.

Cited by 39 publications

References 21 publications

Implants in the Medically Compromised Patient

Implants in the Medically Compromised Patient

Role of Polymorphonuclear Leukocyte-Derived Serine Proteinases in Defense againstActinobacillus actinomycetemcomitans

The Prosthodontic Management of a Young Edentulous Patient with the Papillon Lefevre Syndrome-A Rare Case Report

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