Osseointegration: Hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales

Coelho, Paulo G.; Jimbo, Ryo; Tovar, Nick; Bonfante, Estevam A.

doi:10.1016/j.dental.2014.10.007

Cited by 188 publications

(212 citation statements)

References 143 publications

(189 reference statements)

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“…According to the literature, this combination of micro-and nanoroughness should be favorable in terms of osseointegration [17][18][19]. Besides, the increase in the fluorine content of the surface ( Figure 5) could enhance osteoblastic differentiation and interfacial bone formation as it does for titanium [68].…”

Section: Discussionmentioning

confidence: 99%

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Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

et al. 2016

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Due to their outstanding mechanical properties and excellent biocompatibility, zirconiatoughened alumina (ZTA) ceramics have become the gold standard in orthopedics for the fabrication of ceramic bearing components over the last decade. However, ZTA is bioinert, which hampers its implantation in direct contact with bone. Furthermore, periprosthetic joint infections are now the leading cause of failure for joint arthroplasty prostheses. To address both issues, an improved surface design is required: a controlled micro-and nano-roughness can promote osseointegration and limit bacterial adhesion whereas surface porosity allows loading and delivery of antibacterial compounds. In this work, we developed an integrated strategy aiming to provide both osseointegrative and antibacterial properties to ZTA surfaces. The microtopography was controlled by injection molding. Meanwhile a novel process involving the selective dissolution of zirconia (selective etching) was used to produce nano-roughness and interconnected nanoporosity. Potential utilization of the porosity for loading and delivery of antibiotic molecules was demonstrated, and the impact of selective etching on mechanical properties and hydrothermal stability was shown to be limited. The combination of injection molding and selective etching thus appears promising for fabricating a new generation of ZTA components implantable in direct contact with bone.3

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Section: Discussionmentioning

confidence: 99%

“…In particular it has been shown that rough surfaces exhibit a better bone response than smooth ones and that the combination of micro-and nano-scale roughness can have synergistic effects [17][18][19]. On the other hand, numerous surface engineering strategies have been explored to prevent infection.…”

Section: Introductionmentioning

confidence: 99%

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

et al. 2016

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“…This constitutes an interesting result given the high sensitivity of osteoblasts to roughness at different scales [7,9,[38][39][40][41] and the strong influence of fractal dimension on osteoblastic adhesion and differentiation [10]. Regarding the roughness parameters, although the lack of standardization in the measurements makes comparison difficult with other studies, the values of S a , S dr , S ds and S ci which were obtained here fall within the range of the reported values for commercial dental implants with proved high success rate [8,[42][43][44].…”

Section: Evolution Of the Surface Topography Over Etching Timementioning

confidence: 99%

“…In particular it has been shown that rough surfaces exhibit a better bone response than smooth ones, and that the combination of micro-and nano-scale roughness could have synergistic effects [7][8][9]. Nevertheless, what is the optimal roughness for a dental implant remains unclear [8,9].…”

Section: Introductionmentioning

confidence: 99%

Hydrofluoric acid etching of dental zirconia. Part 1: etching mechanism and surface characterization

Flamant

Marro

Rovira

et al. 2016

Journal of the European Ceramic Society

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Rough surfaces have been shown to promote osseointegration, which is one of the keys for a successful dental implantation. Among the diverse treatments proposed to roughen zirconia, hydrofluoric acid (HF) etching appears to be a good candidate, however little is known about this process. In this work, the effect of HF concentration and etching time on the surface topography and chemistry of yttria-stabilized zirconia was assessed.Besides, to understand the etching mechanism, the reaction products present in solution and on the surface were characterized. The results indicate suitable parameters for a fast and uniform roughening of zirconia. The formation of adhered fluoride precipitates on the surface is reported for the first time and highlights the importance of cleaning after etching. Finally, it is shown that monitoring the time allows controlling the surface roughness, smooth-rough transition and fractal dimension, which should make possible the fabrication of implants with an optimal topography.

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“…Coelho y colegas mencionan que estos procesos de osteointegración a escala nanométrica desempeñan un papel fundamental en el desarrollo del diseño, ya que es posible identificar las "respuestas biológicas como: el crecimiento, la interacción entre células y la presencia de proteínas, (…) así como para medir las condiciones de consolidación ósea" para conocer la superficie y la rugosidad idónea donde será instalado el implante. Esto sugiere que la nanometrología desempeña un papel fundamental, tanto para la determinación de las características topográficas como las propiedades físico-químicas de los huesos en la determinación del diseño del implante y en el proceso de osteointegración, siendo todas estas características importantes para considerar al fabricar los implantes, de manera que se consuma menos tiempo, material y que el proceso sea más eficiente [42].…”

Section: áReas En Desarrollounclassified

Nanometrología: Impacto en los sistemas de producción

Gómez

Jaramillo

2016

Cien.Ing.Neogranadina

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<p>El presente trabajo es el resultado de una revisión bibliográfica sobre: la aplicación de la nanometrología en diferentes sectores industriales y cómo esta contribuye a alcanzar los estándares de calidad de los productos a través de la medición de parámetros críticos en los procesos productivos; así como una descripción de los retos a los que se enfrenta esta ciencia en diferentes sectores. Se reportan los avances y el desarrollo de nuevas técnicas que permiten medir las características de los nanodispositivos, nanomateriales y equipos, lo que ha permitido potenciar el desarrollo de industrias, una disminución de los costos y la automatización de los procesos. Dentro del texto se hace referencia a industrias en progreso y el efecto que tiene el control de parámetros para la optimización de los procesos, el diseño de nanodispositivos y la creciente necesidad de la reglamentación en el uso de nanocompuestos, el diseño de técnica confiables y de protocolos para el uso de nanopartículas. El adelanto de la nanometrología ha contribuido al desarrollo de materiales de referencia, herramientas que aumenten la exactitud y precisión de las medidas, así como técnicas para la calibración de las herramientas y equipos apropiados para las medidas a nanoescala, lo que se traduce en un proceso productivo controlado que garantiza la calidad de los productos. Finalmente, se incluye el estado de la nanometrología en Colombia, enfocada en procesos industriales, como: el sector de alimentos, textil, salud y producción de nanomateriales, así como el trabajo desarrollado por grupos de investigación.</p>

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Osseointegration: Hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales

Cited by 188 publications

References 143 publications

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

Hydrofluoric acid etching of dental zirconia. Part 1: etching mechanism and surface characterization

Nanometrología: Impacto en los sistemas de producción

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