Osseous adaptation to continuous loading of rigid endosseous implants

Roberts, W. Eugene; Smith, R K; Zilberman, Yerucham; Mozsary, Peter G.; Smith, Richard S.

doi:10.1016/0002-9416(84)90301-4

Cited by 446 publications

(280 citation statements)

References 39 publications

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“…So far, there has been only one attempt in the orthodontic literature to systematically define the role of a static load superimposed on function (Roberts et al, 1984).…”

Section: Impact On Biological Responsesmentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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“…So far, there has been only one attempt in the orthodontic literature to systematically define the role of a static load superimposed on function (Roberts et al, 1984).…”

Section: Impact On Biological Responsesmentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

View full text Add to dashboard Cite

show abstract

“…Z kolei Roberts i wsp. 22 stwierdzili, że u królika już okres 6 tygodni jest wystarczają-cy, aby wszczepy osiągnęły pełną integrację.…”

Section: Analiza Korelacji Wyników Pomiarów Urzą-dzeniem Osstell Mentunclassified

The analysis of primary and secondary stability of implants with modified surfaces based on Osstell Mentor and Periotest S comparison: An animal study

Leda¹,

Gajdus²,

Wawrzyniak³

et al. 2015

Protet Stomatol

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“…7 Several investigators have reported the use of osseointegrated implants for uprighting molars to minimise adverse sequelae, such as extrusion. [10][11][12] In 1997 Kanomi placed mini-bone screws between the root apices of the mandibular incisors to intrude the lower anteriors. 4 More recently, Park, Lee, and an increasing number of investigators have discussed the use of microimplants for skeletal anchorage.…”

Section: Types Of Implant Anchorsmentioning

confidence: 99%