Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People

Abstract

Objective: To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 10 3) over time among cognitively normal older people. Methods: We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal cognition (NC) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. At baseline, a total of 372 individuals with NC were included. Results: In the cross-sectional analyses of baseline data, we did not find a significant relationship between OA and HpVR among individuals with NC. However, in the longitudinal analyses, OA was significantly associated with change in HpVR over time among individuals with NC. Specifically, compared with individuals without OA, those with OA showed a faster decline in HpVR over time when controlling for other potential confounders, including age, educational attainment, gender, and APOE4 genotype. Conclusion: OA status was significantly associated with a change in HpVR over time among individuals with NC.

Osteoporosis is associated with elevated baseline cerebrospinal fluid biomarkers and accelerated brain structural atrophy among older people

“…For more than a decade, ADNI researchers have been working to better understand AD. In addition to studying AD itself, many researchers, including ourselves, are interested in investigating the links between AD and other diseases, such as osteoarthritis (Li et al, 2020), Parkinson's disease (Wang et al, 2018), hearing loss (Xu et al, 2019), hypertension (Scott et al, 2015;Zhou et al, 2020), and hypercholesterolemia (Varma et al, 2021), from the ADNI database. To the best of our knowledge, this is the first study to demonstrate the links between OP and higher levels of CSF t-tau and p-tau 181 at baseline, and the faster volumetric declines of enterhinal cortex and hippocampus over time among older people.…”

“…This could lead to some wrong classifications. Even so, this is a common limitation of database-based research (Norton et al, 2014;Frain et al, 2017;Xu et al, 2019;Harshfield et al, 2020;Li et al, 2020;Kwon et al, 2021). Future studies are encouraged to extend our work to other databases to verify our results.…”

Depression in Osteoarthritis: Current Understanding

“… 69 MRI scans of the brains of people with OA have shown that people with OA have faster declines in hippocampal volume than people without OA and people with normal cognition, even after adjusting for factors such as age, gender, education, and APOE4 genotype. 70 Brain structural studies of people with depression have consistently found smaller hippocampal volumes in people with MDD compared to people without depression. 70 It is clear that there is an association between the functional and structural changes in the specific brain regions involved in OA pain processing and depressive symptoms.…”

“… 70 Brain structural studies of people with depression have consistently found smaller hippocampal volumes in people with MDD compared to people without depression. 70 It is clear that there is an association between the functional and structural changes in the specific brain regions involved in OA pain processing and depressive symptoms. In fact, few studies exist for the depression comorbid OA group, which makes it difficult to compare more clearly the changes in the brain of patients with OA and comorbid depression.…”

Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer’s disease

“…According to Xue, in 2018, the prevalence of dementia in an OA group was higher than that in the non-OA group (HR 1.42, 95% CI, 1.30-1.54); OA treatment reduced the risk of dementia [3]. Despite ongoing epidemiological studies on the correlation between dementia and OA [4][5][6], there is still no direct evidence showing its causal relationship.…”