Osteoblast proliferation and maturation by bisphosphonates

Im, Gun‐Il; Qureshi, Sheeraz A.; Kenney, Jennifer; Rubash, Harry E.; Shanbhag, Arun S.

doi:10.1016/j.biomaterials.2003.11.024

Cited by 356 publications

(256 citation statements)

References 59 publications

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“…Recent in vitro studies suggest that bisphosphonates impact both bone resorption and bone formation [39][40][41][42]. It was reported that bisphosphonates inhibit osteoclastic activity and exert an anabolic effect on osteoblasts by altering osteoblast-specific gene expression and enhancing differentiation of human BMSCs [39][40][41][42].…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that bisphosphonates inhibit osteoclastic activity and exert an anabolic effect on osteoblasts by altering osteoblast-specific gene expression and enhancing differentiation of human BMSCs [39][40][41][42]. Bisphosphonates may also contribute to increasing the life span of osteoblasts through mechanisms that inhibit osteoblast apoptosis [43].…”

Section: Discussionmentioning

confidence: 99%

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Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation

Pettway

Meganck

Koh

et al. 2008

Bone

107

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PTH (1-34) is the only FDA-approved anabolic agent for osteoporosis treatment in the U.S., but its mechanisms are not completely understood. This study investigated PTH effects on osteogenic cells at various stages of differentiation and proliferation using an engineered bone growth model in vivo. Ossicles were generated from bone marrow stromal cells (BMSCs) implanted in immunocompromised mice. Three weeks of PTH (40μg/kg/d) or vehicle treatment initiated 1 day, 1, 2, or 3wks after BMSC implantation resulted in an anabolic response in PTH-treated implants (via histomorphometry and microCT) in all treatment groups. A novel in vivo tracking strategy with luciferase tagged BMSCs and weekly bioluminescent imaging of ossicles revealed increased donor cell proliferation in PTH-treated ossicles. The greatest increase occurred during the first week, and the activity remained elevated in PTH-treated implants over time. Zoledronic acid (ZA) was combined with PTH to delineate interactive mechanisms of these bone active agents. Combining ZA with PTH treatment reduced the PTH-mediated increase in luciferase BMSC activity, serum osteocalcin, and serum tartrate resistant acid phosphotase-5b (TRAP-5b) but ZA did not reduce the PTH-induced increase in total bone. Since zoledronic acid reduced PTH-induced proliferation without reducing bone volume, these data suggests that combining PTH and bisphosphonate therapy warrants further investigation in the treatment of bone disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation

Pettway

Meganck

Koh

et al. 2008

Bone

107

View full text Add to dashboard Cite

show abstract

“…Several in vitro studies have shown that alendronate can increase differation, maturation, and proliferation of osteoblasts. 26,27 One of our concerns regarding the use of bisphosphonate as adjuvant in implant fixation is the effect of decreasing bone turnover. An impaired bone turnover might lead to increased bone fragility and accumulation of microfractures, 28 resulting in reduced long-term implant fixation.…”

Section: Discussionmentioning

confidence: 99%

Local alendronate increases fixation of implants inserted with bone compaction: 12‐week canine study

Jakobsen

Kold

Bechtold

et al. 2006

Journal Orthopaedic Research

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Bone compaction has been shown to increase initial implant fixation. Furthermore, bone compaction creates a peri-implant zone of autograft that exerts osteoconductive properties. We have previously shown that locally applied bisphosphonate (alendronate) at 4-week observation can preserve the autograft generated by bone compaction. We now investigate whether the increased amount of autograft, seen at 4 weeks, can increase implant osseointegration and biomechanical fixation. Porous-coated titanium implants were bilaterally inserted with bone compaction into the proximal part of tibia of 10 dogs. On the right side, local bisphosphonate was injected into the bone cavity prior to bone compaction immediately prior to implant insertion. On the left side, saline was used as control. Observation period was 12 weeks. Locally applied bisphosphonate significantly increased biomechanical implant fixation (approximately twofold), bone-to-implant contact (1.2-fold), and peri-implant bone volume fraction (2.3-fold). This study indicates that local alendronate treatment can increase early implant osseointegration and biomechanical fixation of implants inserted by use of bone compaction. Long term effects remain unknown. ß

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“…They directly enhance osteoblast proliferation and promote a differentiation of osteoprogenitor cells towards the osteoblastic pathway. 36,37 Bisphosphonates also prevent osteoblast apoptosis 38,39 and upregulate production of extracellular matrix proteins by osteoblasts. 35 These effects have been reported for different members of the bisphosphonate family, including zoledronic acid, pamidronate, neridronate, alendronate and risedronate.…”

Section: Discussionmentioning

confidence: 99%

Effects of various antireabsorptive treatments on bone mineral density in hypogonadal young women after allogeneic stem cell transplantation

Tauchmanovà

Simone

Musella

et al. 2005

Bone Marrow Transplant

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Osteoblast proliferation and maturation by bisphosphonates

Cited by 356 publications

References 59 publications

Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation

Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation

Local alendronate increases fixation of implants inserted with bone compaction: 12‐week canine study

Effects of various antireabsorptive treatments on bone mineral density in hypogonadal young women after allogeneic stem cell transplantation

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