Osteoblastic cell response on fluoridated hydroxyapatite coatings

Wang, Yongsheng; Zhang, Sam; Zeng, Xin; Lwin, Lwin; Weng, Wenjian; Yan, Wei; Qian, Min

doi:10.1016/j.actbio.2006.10.002

Cited by 152 publications

(115 citation statements)

References 29 publications

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“…ALP decrease could represent a return to osteoprogenitor cells or maturation to osteocytes, which normally express small quantities of this enzyme. These results were in accord with those of Genge et al (1988) and Wang et al (2007). There was a major decline in ALP activity during matrix vesicle mineralization.…”

Section: In Vitro Evaluation Of the Osteoblast Seeded Cockle Shell-basupporting

confidence: 83%

“…It was reported that ALP is associated with calcification and an enhanced expression of this enzyme is apparently needed just before the onset of matrix mineralization, providing localized enrichment of inorganic phosphate, one of the components of apatite, the mineral phase of bone (Genge et al, 1988). In the current research work, the ALP results as showed in figure 5 agree with the results reported by many investigators, namely, Toquet et al (1999), Kose et al (2003), Park et al (2004), Datta et al (2005), and Wang et al (2007). During the early period (from 5 to 14 days) the extracellular matrix undergoes a series of modifications in composition and organization that renders it competent for mineralization.…”

Section: In Vitro Evaluation Of the Osteoblast Seeded Cockle Shell-basupporting

confidence: 81%

See 1 more Smart Citation

Cockle Shell-Based Biocomposite Scaffold for Bone Tissue Engineering

Bakar¹,

Hussein²,

Mustapha³

2011

Regenerative Medicine and Tissue Engineering - Cells and Biomaterials

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Section: In Vitro Evaluation Of the Osteoblast Seeded Cockle Shell-basupporting

confidence: 83%

Section: In Vitro Evaluation Of the Osteoblast Seeded Cockle Shell-basupporting

confidence: 81%

Cockle Shell-Based Biocomposite Scaffold for Bone Tissue Engineering

Bakar¹,

Hussein²,

Mustapha³

2011

Regenerative Medicine and Tissue Engineering - Cells and Biomaterials

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“…The influence of fluorine on the surface of the anodized nanotubular titanium clearly may change cell responses compared to unanodized titanium which did not have fluorine on its surface. [15][16][17] Jin et al 17 claimed that there might be a threshold value for the concentration of fluorine where lower concentrations stimulate the proliferation of certain cells (such as osteoblasts or bone-forming cells) and higher concentrations are toxic for cells. Future studies should create anodized nanotubular titanium without the presence of fluorine (such as by applying heat treaments after the anodization process) to delineate the effect of fluorine on urothelial cells.…”

Section: Resultsmentioning

confidence: 99%

Anodized 20 nm diameter nanotubular titanium for improved bladder stent applications

Alpaslan¹,

Ercan²,

Webster³

2011

IJN

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Materials currently used for bladder applications often suffer from incomplete coverage by urothelial cells (cells that line the interior of the bladder and ureter) which leads to the continuous exposure of the underlying materials aggravating an immune response. In particular, a ureteral (or sometimes called an ureteric or bladder) stent is a thin tube inserted into the ureter to prevent or treat obstruction of urine flow from the kidney. The main complications with ureteral stents are infection and blockage by encrustation, which can be avoided by promoting the formation of a monolayer of urothelial cells on the surface of the stent. Nanotechnology (or the use of nanomaterials) may aid in urothelialization of bladder stents since nanomaterials have been shown to have unique surface energetics to promote the adsorption of proteins important for urothelial cell adhesion and proliferation. Since many bladder stents are composed of titanium, this study investigated the attachment and spreading of human urothelial cells on different nanotextured titanium surfaces. An inexpensive and effective scaled up anodization process was used to create equally distributed nanotubular surfaces of different diameter sizes from 20–80 nm on titanium with lengths approximately 500 nm. Results showed that compared to untreated titanium stents and 80 nm diameter nanotubular titanium, 20 nm diameter nanotubular titanium stents enhanced human urothelial cell adhesion and growth up to 3 days in culture. In this manner, this study suggests that titanium anodized to possess nanotubular surface features should be further explored for bladder stent applications.

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“…Silicon can increase the bone mineralization rate and enhance the osteoblast proliferation, differentiation and collagen production [62]. Fluoride, which is good for teeth, can stabilize apatite and also stimulate the osteoblast activity [61,67]. Magnesium has been found in high concentrations in bone and cartilage tissue during the initial phases of osteogenesis, and to cause the acceleration of the nucleation kinetics of hydroxyapatite and to inhibit its crystallization process.…”

Section: Growth Of Biomimetic Ion Doped Ha On Titanium Oxide Surfacesmentioning

confidence: 99%