Osteoblastic cells colonization inside beta-TCP macroporous structures obtained by ice-templating

Meurice, Edwige; Bouchart, Franck; Hornez, Jean‐Christophe; Leriche, Anne; Hautcoeur, Dominique; Lardot, Véronique; Cambier, F.; Fernandes, Maria Helena; Monteiro, Fernando J.

doi:10.1016/j.jeurceramsoc.2015.10.030

Cited by 30 publications

(13 citation statements)

References 18 publications

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“…Non-stoichiometric nanocrystalline calcium phosphate apatites [7,8] mainly fit the two first criteria, due to their biomimetic characteristics (structural and chemical similarity with the mineral phase of bone) supporting their high bioactivity. Different processes (hard template [9], ice-templating [10]) can lead to porous calcium phosphate ceramics but mechanical cohesion is only obtained after a sintering step at high temperature. Unfortunately, these ceramics exhibit high fragility and low elasticity [11,12].…”

Section: Introductionmentioning

confidence: 99%

Freeze-casting for PLGA/carbonated apatite composite scaffolds: Structure and properties

Schardosim

Soulié

Poquillon

et al. 2017

Materials Science and Engineering: C

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This paper focuses on the fabrication of three-dimensional porous PLGA-biomimetic carbonated apatite composite scaffolds by freeze-casting and using dimethyl carbonate as a solvent. Several charge/polymer ratios were tested in order to finely understand the influence of the filler rate on the scaffold porosity and mechanical and degradation properties using complementary characterization techniques (SEM, mercury porosimetry and X-ray microtomography). It was demonstrated that the apatite ratio within the composite scaffold has a strong influence in terms of architecture, material cohesion, mechanical properties and in vitro degradation properties. An optimum biomimetic apatite ratio was reached to combine good mechanical properties (higher rigidity) and material cohesion. In vitro degradation studies showed that higher apatite filler rates limited PLGA degradation and enhanced the hydrophilicity of the scaffolds which is expected to improve the biological properties of the scaffolds in addition to the bioactivity related to the presence of the apatite analogous to bone mineral.

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Section: Introductionmentioning

confidence: 99%

Freeze-casting for PLGA/carbonated apatite composite scaffolds: Structure and properties

Schardosim

Soulié

Poquillon

et al. 2017

Materials Science and Engineering: C

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“…C'est dans cette zone centrale que s'élabore le dommage. On peut noter que cette zone apparaît foncée au microscope électronique, ce qui indique qu'elle est formée de métaux peu oxydés [6,7]. Dans la zone II, la surface est formée par des fines particules agglomérées et oxydées.…”

Section: Influence Des Paramètres Opératoiresunclassified

“…Présentant une bonne dureté et une ténacité élevée, les aciers de type austénitique sont surtout utilisés pour des articulations artificielles [6][7][8][9]. Aussi, à l'instar de l'alliage 316L, et afin d'améliorer la résistance à la corrosion, des solutions solides en austénite stable (Ni > 12 à 14 %) sont utilisées [7].…”

Section: Introductionunclassified

Comportement à l’usure et au frottement de deux biomatériaux AISI 316L et Ti-6Al-7Nb pour prothèse totale de hanche

Fellah

Aissani

Iost

et al. 2018

Matériaux & Techniques

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On s’est intéressé dans ce travail à l’analyse du comportement à l’usure et au frottement de deux prothèses totales de hanche en acier AISI 316L et en alliage à base de titane Ti-6Al-7Nb. Les propriétés tribologiques d’usure par glissement sont évaluées à l’aide d’un tribomètre TriboTechnic muni du logiciel tribotester, en accord avec les standards ASTM G 133–95, ISO 7148-1:2012 et ASTMG 99, en présence d’un milieu physiologique (solution de Hank) à une température de 28 à 30 °C. La bille en alumine (Al2O3) a été choisie comme antagoniste. Trois vitesses (1, 6 et 15 mm.s−1) et quatre forces normales (2,4,6 et 10 N) ont été appliquées. Après chaque essai de frottement, l’état de surface a été analysé par un microscope électronique à balayage. Le coefficient de frottement et le volume d’usure étaient plus faibles dans les échantillons testés à une force appliquée de 2 N sous une vitesse de 1 mm.s−1 (0,12 et 0,33) et (0,07 × 107 et 0,09 × 107 μm3) pour l’acier AISI 316L et le Ti-6Al-7Nb, respectivement. Les valeurs du coefficient de frottement obtenues respectent les normes imposées par le domaine du biomédical notamment au niveau de l’état de surface articulaire des prothèses de hanche.

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“…Porous ceramics are used for different applications such as catalyst supports [1], biocompatible scaffolds [2], piezoelectric supports [3], membranes [4], thermal insulation devices [5], electrodes for fuel cells [6], preforms for processing ceramic/metal composites [7] and so on. Specific characteristics of the porous structure (pore size distribution, permeability, chemical stability, structure control) are required depending on the application.…”

Section: Introductionmentioning

confidence: 99%

Alumina Porous Ceramics Obtained by Freeze Casting: Structure and Mechanical Behaviour under Compression

et al. 2018

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The aim of the work is to analyse the mechanical behaviour of anisotropic porous alumina ceramics processed by freeze casting (ice templating). The freeze cast specimens were characterised by a lamellar structure with ellipsoidal pore shape, with a size ranging from 6 to 42 µm and 13 to 300 µm for the minor and major axes, respectively, as a function of the freezing rate and the powder and binder contents. The pore volume fraction ranged from 40 to 57%. SEM analysis of the porous structures after the compression test showed a typical deformation pattern caused by the porosity gradient through the specimen, as determined by X-ray radiography. The apparent elastic modulus of the anisotropic porous alumina ranged from 0.2 to 14 GPa and the compressive strength from 6 to 111 MPa, varying as a function of the process parameters which determine the pore network characteristics. The relationships between stress-strain behaviour in compression and the microstructure and texture were established. An analytical model based on a Gibson and Ashby relationship was used and adapted from SEM microstructural analysis after a mechanical test in order to predict the compressive strength of processed anisotropic alumina.

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Osteoblastic cells colonization inside beta-TCP macroporous structures obtained by ice-templating

Cited by 30 publications

References 18 publications

Freeze-casting for PLGA/carbonated apatite composite scaffolds: Structure and properties

Freeze-casting for PLGA/carbonated apatite composite scaffolds: Structure and properties

Comportement à l’usure et au frottement de deux biomatériaux AISI 316L et Ti-6Al-7Nb pour prothèse totale de hanche

Alumina Porous Ceramics Obtained by Freeze Casting: Structure and Mechanical Behaviour under Compression

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