Osteochondral lesion located at the lateral femoral condyle reconstructed by the transplantation of tissue-engineered cartilage in combination with a periosteum with bone block: a case report

Adachi, Nobuo; Ochi, Mitsuo; Uchio, Yuji; Iwasa, Junji; Furukawa, S.; Deie, Masataka

doi:10.1007/s00167-004-0531-7

Cited by 8 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 Numerous preclinical studies and some clinical successes indicated that these tissue engineering approaches are scientifically practical. [3][4][5] However, restricted by high cost and complexity of production, the tissue engineering products have not yet been commercially effective. 6 These issues may retain tissue engineering as a costly and exclusive treatment for those who can afford.…”

Section: Introductionmentioning

confidence: 99%

A novel osteogenesis technique: The expansible guided bone regeneration

2012

View full text Add to dashboard Cite

Guided bone regeneration is a unique osteogenesis technique that requires a barrier membrane under periosteum to create space for bone regeneration. However, creating sizeable spaces is clinically not commonly feasible. A titanium plate and a thin silicone membrane were surgically layered on each calvaria of eight rabbits. Then, the periphery of the silicone membrane was fixed by a plastic ring to the underlying bone using titanium micro screws. After 1 week, a 5-mm-length titanium screw was used to elevate the titanium plate, which in turn elevated the silicone membrane together with overlying soft tissue in a rate of 1 mm/day for 5 days to create a secluded space. Animals were killed at 2 months (n = 4, group 1) and 4 months (n = 4, group 2) after the elevation. Histological and microradiographical analyses demonstrated creation of an amount of de novo bone formation (68.2 ± 22 mm3 in group 1 and 70.3 ± 14 mm3 in group 2) in the sizeable created spaces (207.1 ± 31 mm3 in group 1 and 202 ± 21 mm3 in group 2) without exposure of the device. This novel osteogenesis technique, “expansible guided bone regeneration,” created a substantial in vivo incubator without applying growth factors or osteoprogenitor cells. Creating a growing space over the secluded surface allowed the development of normal biological healing process occurring on the bone surface into a regenerative process, generating bone outside the genetically determined skeletal bone. This technique is a new tissue engineering approach stimulating endogenous tissue repair without applying cells or factors exogenously.

show abstract

Section: Introductionmentioning

confidence: 99%

A novel osteogenesis technique: The expansible guided bone regeneration

2012

View full text Add to dashboard Cite

show abstract

“…8,30,31 Biphasic grafts, hyaluronan and polyester-based scaffolds, biochemically treated mesenchymal progenerator cells, and the tissue engineered osteochondral substitutes, although quite promising, are considered investigational. 1,7,14,22,25,34,[44][45][46]49,51,52,55,57,58 Osteochondral allograft transplantation (OCA) is appealing because it provides the ability to resurface larger and deeper defects with mature hyaline articular cartilage and addresses the underlying bone deficit in a single procedure. The appropriate size and surface contour can be matched when the graft is obtained from an appropriately selected organ donor.…”

mentioning

confidence: 99%

Prospective Evaluation of Prolonged Fresh Osteochondral Allograft Transplantation of the Femoral Condyle

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Randomized clinical trials have been performed, showing that this technique is superior to microfracture and as good or better than ACI in small to medium lesions [35, 55, 64], whereas doubts remain for bigger lesions. Adachi et al [2] documented a case report where lateral compartment postmeniscectomy OA in a 14‐year‐old girl was successfully treated with concurrent tissue‐engineered cartilage for a femoral lesion and OAT for a tibial lesion. Kock et al [74] treated a medial femoral condyle (MFC) lesion in a 43‐year‐old man with a dysfunctional reconstructed ACL and mild degenerative changes of the lateral compartment, with only an initial improvement and a failure after 3 years.…”

Section: Resultsmentioning

confidence: 99%

Surgical treatment for early osteoarthritis. Part I: cartilage repair procedures

Gomoll

Filardo

Girolamo

et al. 2011

Knee Surg Sports Traumatol Arthrosc

132

View full text Add to dashboard Cite

Young patients with early osteoarthritis (OA) represent a challenging population due to a combination of high functional demands and limited treatment options. Conservative measures such as injection and physical therapy can provide short-term pain relief but are only palliative in nature. Joint replacement, a successful procedure in the older population, is controversial in younger patients, who are less satisfied and experience higher failure rates. Therefore, while traditionally not indicated for the treatment of OA, cartilage repair has become a focus of increased interest due to its potential to provide pain relief and alter the progression of degenerative disease, with the hope of delaying or obviating the need for joint replacement. This review of cartilage repair techniques will discuss currently available procedures, specifically pertaining to experiences in the setting of early OA. Level of evidence IV.

show abstract

Osteochondral lesion located at the lateral femoral condyle reconstructed by the transplantation of tissue-engineered cartilage in combination with a periosteum with bone block: a case report

Cited by 8 publications

References 13 publications

A novel osteogenesis technique: The expansible guided bone regeneration

A novel osteogenesis technique: The expansible guided bone regeneration

Prospective Evaluation of Prolonged Fresh Osteochondral Allograft Transplantation of the Femoral Condyle

Surgical treatment for early osteoarthritis. Part I: cartilage repair procedures

Contact Info

Product

Resources

About