Osteochondritis dissecans

Franceshi, L. De; Grigolo, Brunella; Roseti, Livia; Marconi, Emanuele; Facchini, Andrea; Buda, Roberto; Vannini, Francesca; Giannini, Sandro

doi:10.1111/j.1365-2559.2007.02711.x

Cited by 6 publications

(2 citation statements)

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“…Oxidation of proteins by free radicals results in the formation of carbonyl groups at the amino acid residues, and therefore in their denaturation. Assessment of total carbonyl derivatives content in synovial fluid samples collected from OCD-related horses joints, revealed increased protein oxidation compared to clinically healthy control groups; thus, high levels of carbonyl protein in the cartilage of diseased horses necessarily implies an abnormally high presence of ROS in the joint, and thus suggests the involvement of oxidative stress in joint damage [ 105 ]. In addition, the presence of high concentrations of ROS was correlated with the sharp decrease in the viscosity of hyaluronan, leading to the loss of its elasticity and the onset of increased friction of the joints.…”

Section: Impact Of Oxidative Stress In the Course Of Ocd Developmentmentioning

confidence: 99%

Osteochondritis dissecans (OCD) in Horses – Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy

Bourebaba

Röcken

Marycz

2019

Stem Cell Rev and Rep

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Osteochondrosis (osteochondrosis dissecans; OCD) is a disease syndrome of growing cartilage related to different clinical entities such as epiphysitis, subchondral cysts and angular carpal deformities, which occurs in growing animals of all species, including horses. Nowadays, these disorders are affecting increasing numbers of young horses worldwide. As a complex multifactorial disease, OCD is initiated when failure in cartilage canals because of existing ischemia, chondrocyte biogenesis impairment as well as biochemical and genetic disruptions occur. Recently, particular attention have been accorded to the definition of possible relations between OCD and some metabolic disorders; in this way, implication of mitochondrial dysfunctions, endoplasmic reticulum disruptions, oxidative stress or endocrinological affections are among the most considered axes for future researches. As one of the most frequent cause of impaired orthopaedic potential, which may result in a sharp decrease in athletic performances of the affected animals, and lead to the occurrence of complications such as joint fragility and laminitis, OCD remains as one of the primary causes of considerable economic losses in all sections of the equine industry. It would therefore be important to provide more information on the exact pathophysiological mechanism(s) underlying early OC(D) lesions, in order to implement innovative strategies involving the use of progenitor stem cells, which are considered nowadays as a promising approach to regenerative medicine, with the potential to treat numerous orthopaedic disorders, including osteo-degenerative diseases, for prevention and reduction of incidence of the disease, not only in horses, but also in human medicine, as the equine model is already widely accepted by the scientific community and approved by the FDA, for the research and application of cellular therapies in the treatment of human conditions.

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Section: Impact Of Oxidative Stress In the Course Of Ocd Developmentmentioning

confidence: 99%

Osteochondritis dissecans (OCD) in Horses – Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy

Bourebaba

Röcken

Marycz

2019

Stem Cell Rev and Rep

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5]7,8 Hence, it was hypothesized that subchondral bone sufferance following an initial damage, either vascular and traumatic in origin, is the main cause of chondral apoptosis and subsequent cartilage degeneration, eventually producing an osteochondral fragment. 9 Excluding asymptomatic cases, pain and tenderness are the most frequent symptoms 1,2,4,10 Swelling and limping are often reported as well. In the presence of a loose body, locking or catching may occur.…”

Section: Research-article2016mentioning

confidence: 99%