Osteochondrom und multiple Osteochondrome

Herget, Georg W.; Kontny, Udo; Saueressig, Ulrich; Baumhoer, Daniel; Hauschild, Oliver; Elger, Tania; Südkamp, Norbert P.; Uhl, Markus

doi:10.1007/s00117-013-2571-9

Cited by 29 publications

(9 citation statements)

References 26 publications

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“…In the case of multiple lesions, the risk of malignant progression before the end of bone growth has been estimated at approximately 1-4%. Therefore, in patients with multiple lesions, early surgical intervention should be the treatment of choice [2,9,10].…”

Section: Discussionmentioning

confidence: 99%

The Epidemiology of Benign Proliferative Processes of the Skeletal System in Children

Rutkowski

Niewinska

2021

IJERPH

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A suspicion of a proliferative bone lesion in a child seems to be a major diagnostic problem for clinicians. There are no diagnostic and treatment algorithms described in the literature and no reliable cohort epidemiological data. Our study was conducted among 289 paediatric patients (0–18 years old) with an initial diagnosis of a bone tumour or tumour-like lesion. The study comprised a retrospective epidemiological analysis, an assessment of the concordance of the initial diagnoses with the histopathological diagnoses and an analysis of the specific locations of the various bone lesions. The results obtained have made it possible to formulate the following conclusions. (1) The most common proliferative bone lesion in children is osteochondroma; also common are fibrous dysplasia, non-ossifying fibromas and bone cysts. (2) Verifying the initial diagnosis by means of biopsy is essential. (3) Osteochondromas are typically located in the metaphyses of long bones, fibrous dysplasia in the femur and skull, cyst-like lesions in the proximal humerus and non-osteochondral fibromas exclusively in the lower limbs. What could improve the quality of treatment for children with primary proliferative bone diseases is the establishment of centres of paediatric orthopaedic oncology skilled in early diagnosis and prompt management.

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Section: Discussionmentioning

confidence: 99%

The Epidemiology of Benign Proliferative Processes of the Skeletal System in Children

Rutkowski

Niewinska

2021

IJERPH

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“…Sie können die angrenzenden Epiphysenfugen beeinträchtigen, sodass insbesondere bei HMO häufig kürzere, teilweise deformierte Extremitäten entstehen. Wenn 2 oder mehr Osteochondrome vorliegen, ist eine Ganzkörper-MRT indiziert, welche abhängig von der Lokalisation der Osteochondrome nach Wachstumsabschluss wiederholt werden sollte [19]. Hierbei ist in der Regel eine native Untersuchung ausreichend, möglicherweise mit ergänzenden diffusionsgewichteten Sequenzen [20,21].…”

Section: Benigne Chondrogene Tumorenunclassified

“…Hierbei ist in der Regel eine native Untersuchung ausreichend, möglicherweise mit ergänzenden diffusionsgewichteten Sequenzen [20,21]. Bei solitären und multiplen Osteochondromen sollten je nach Lokalisation 1-3-jährliche klinische Kontrollen und gegebenenfalls eine ergänzende Bildgebung erfolgen; bei der HMO sollten eine jährliche klinische Kontrolle und 1-2-jährliche MR-Bildgebung der Läsionen mit noch vorhandener Knorpelkappe erfolgen [19].…”

Section: Benigne Chondrogene Tumorenunclassified

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Engel

Herget

Füllgraf

et al. 2020

Rofo

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Background Chondrogenic tumors are the most frequent primary bone tumors. Malignant chondrogenic tumors represent about one quarter of malignant bone tumors. Benign chondrogenic bone tumors are frequent incidental findings at imaging. Radiological parameters may be helpful for identification, characterization, and differential diagnosis. Methods Systematic PubMed literature research. Identification and review of studies analyzing and describing imaging characteristics of chondrogenic bone tumors. Results and conclusions The 2020 World Health Organization (WHO) classification system differentiates between benign, intermediate (locally aggressive or rarely metastasizing), and malignant chondrogenic tumors. On imaging, typical findings of differentiated chondrogenic tumors are lobulated patterns with a high signal on T2-weighted magnetic resonance imaging (MRI) and ring- and arc-like calcifications on conventional radiography and computed tomography (CT). Depending on the entity, the prevalence of this chondrogenic pattern differs. While high grade tumors may be identified due to aggressive imaging patterns, the differentiation between benign and intermediate grade chondrogenic tumors is challenging, even in an interdisciplinary approach. Key Points: Citation Format

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“…The tumor is presented as a locally benign neoplasm, which favors the meta-epiphyseal region of long bones like the distal femur, as well as the proximal tibia or humerus in the extremity [5] , [6] , [8] . Of all benign bone tumors, OC accounts for more than one-third, the most common benign bone tumor around the world [4] , [7] , [8] , [9] , [10] , [11] , [15] . Although it is benign, its biological behavior still has a malignant potential.…”

Section: Introductionmentioning

confidence: 99%

Osteochondroma: Review of 431 patients from one medical institution in South China

Tong

Liu

Wang

et al. 2017

Journal of Bone Oncology

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BackgroundThe geographic distribution of osteochondroma (OC) varies greatly around the world. There has been no recent report on OC in a large Chinese population. The aim of this study was to characterize OC by an epidemiological analysis of the clinical data from one medical institution in South China.MethodsWe searched medical electronic records from January 2001 to January 2016 in one large hospital in South China to identify patients with a definite diagnosis of OC. Their epidemiological data were collected and analyzed statistically, including gender, tumor site, age at first diagnosis and symptoms, local recurrence and malignant transformation. Differences between genders and between solitary osteochondroma (SO) and multiple osteochondroma (MO) were particularly analyzed.ResultsA total of 431 OC patients (291 males and 140 females; 329 SOs and 102 MOs) were identified. The gender ratio was 2.08 with a male predominance. OCs were mostly located around the knee (250 cases). 280 patients were in their 0s to 20s upon first diagnosis. The average age at the time of first diagnosis was 20.63 years for all, 18.47 years for males and 25.11 years for females (P=0.000). OC recurred locally in 35 patients (15 SOs and 20 MOs), with a significant difference between SO/MO (P=0.000) but not between genders (P=0.100). The average interval from the primary surgery to local or malignant recurrence was 37.41 months. Malignant transformation was found in 5 patients (4 males and 1 female), showing no gender difference (P=0.549).ConclusionsOC may have a male predominance in Chinese population. It mostly occurred at 0–20 years of age and around the knee. Upon the first diagnosis of OC, the males tended to be younger than the females, and so did the MO patients than the SO ones. In addition, MO had a higher incidence of local recurrence. Intervals from primary surgery to local recurrence or malignant transformation in MO patients were longer than in SO patients.

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Osteochondrom und multiple Osteochondrome

Cited by 29 publications

References 26 publications

The Epidemiology of Benign Proliferative Processes of the Skeletal System in Children

The Epidemiology of Benign Proliferative Processes of the Skeletal System in Children

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Osteochondroma: Review of 431 patients from one medical institution in South China

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