Osteoconductive bio-based meshes based on Poly(hydroxybutyrate-co-hydroxyvalerate) and poly(butylene adipate-co-terephthalate) blends

Nar, Mangesh; Staufenberg, Gerrit; Yang, Bing; Robertson, L S; Patel, Rinkesh H.; Varanasi, Venu; D’Souza, Nandika Anne

doi:10.1016/j.msec.2014.01.047

Cited by 15 publications

(8 citation statements)

References 30 publications

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“…Many efforts have been made to develop sustainable bio‐based and biodegradable polymers for packaging, automotive, electrical & electronics, household, agriculture, and biomedical application. Commercially available poly(hydroxybutyrate‐co‐hydroxyvalerate) (PHBV) has gained much attention due to its comparable mechanical properties as compared to polyolefin along with excellent biocompatibility and biodegradability 1–5 . As one of the members of the PHA family, PHBV is a copolymer of PHB with randomly arranged 3‐hydroxybutyrate (HB) groups and 3‐hydroxyvalarate (HV) groups and synthesized by various microorganisms 6,7 .…”

Section: Introductionmentioning

confidence: 99%

“…Commercially available poly (hydroxybutyrate-co-hydroxyvalerate) (PHBV) has gained much attention due to its comparable mechanical properties as compared to polyolefin along with excellent biocompatibility and biodegradability. [1][2][3][4][5] As one of the members of the PHA family, PHBV is a copolymer of PHB with randomly arranged 3-hydroxybutyrate (HB) groups and 3-hydroxyvalarate (HV) groups and synthesized by various microorganisms. 6,7 It can be efficiently degraded into carbon dioxide and water by microorganisms in the most biologically active environment.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical properties and structure of injection molded poly(hydroxybutyrate‐co‐hydroxyvalerate)/poly(butylene adipate‐co‐terephthalate) (PHBV/PBAT) blends

Zhao

Zhang

et al. 2023

J of Applied Polymer Sci

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Blending poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and poly(butylene adipate-co-terephthalate) (PBAT) presents an effective approach to fabricate fully biodegradable polymer blends with tailored mechanical properties. This study investigated the composition on the mechanical properties and structure of PHBV/PBAT blend. The remarkable enhancement in elongation of the PHBV/PBAT blends was shown due to the ductile PBAT. The fracture behavior of the PHBV/PBAT specimens transited from brittle to ductile with the increase of the PBAT in the blends. Two different phases as a co-continuous microstructure with a large interpenetrating structure indicate immiscibility between PHBV and PBAT in the PHBV/PBAT (50:50) specimen. The miscibility, intermolecular interaction, and mechanical properties of PHBV/PBAT blends were also investigated by molecular dynamics simulation. The results showed the immiscibility of PHBV and PBAT. The degradation temperature

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanical properties and structure of injection molded poly(hydroxybutyrate‐co‐hydroxyvalerate)/poly(butylene adipate‐co‐terephthalate) (PHBV/PBAT) blends

Zhao

Zhang

et al. 2023

J of Applied Polymer Sci

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“…Moreover, recent studies have shown that it is biocompatible with many cell types. This property makes PBAT a promising synthetic polymeric biomaterial for tissue engineering applications [1][2][3][4][5][6]. Although synthetic biodegradable polymers have many advantages in terms of mechanical properties such as controlled biodegradation rate and processability into various functional shapes, they are lack of biological signals that limit their cell promotion [7].…”

Section: Introductionmentioning

confidence: 99%

Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix

Arslan

Çakmak

Gümüşderelı́oğlu

2018

Artificial Cells, Nanomedicine, and Biotechnology

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In this study, three dimensional (3D) poly(butylene adipate-co-terephthalate) (PBAT) fibrous scaffolds with more than 90% porosity were fabricated via wet electrospinning method. Amorphous hydroxyapatite (HAp) and boron (B) doped hydroxyapatite (B-HAp) nanoparticles were produced by microwave-assisted biomimetic precipitation and encapsulated into PBAT fibres with the ratio of 5% (w/w) in order to enhance osteogenic activity of the scaffolds. Cell culture studies were carried out with human bone marrow derived stem cells (hBMSCs) and they showed that alkaline phosphatase (ALP) activity and the amounts of collagen and calcium were higher on B containing PBAT (B-HAp-PBAT) scaffolds during the 28-day culture period than that of the PBAT scaffolds. Moreover, hBMSCs cultivated on B-HAp-PBAT scaffolds showed significantly higher expression levels of both early and late stage osteogenic genes e.g. ALP, collagen I (COL-I), osteocalcin (OCN) and osteopontin (OPN) at day 28 than that of the PBAT scaffolds. Scanning electron microscope (SEM) photographs and energy dispersive X-ray (EDX) analysis indicated that hBMSCs produced high amounts of mineralized extracellular matrix (ECM) mainly on the surface of the 3 D matrices. This study demonstrates that boron-containing 3 D nanofibrous PBAT scaffolds with their osteoinductive and osteoconductive properties can be used as alternative constructs for bone tissue engineering.

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“…37 Before the test, the area of the sample was determined. The frequency was set from 1-50 s −1 in steps of 1, and the dynamic amplitude was set at 0.1 mm.…”

Section: Dynamic Mechanical Analysismentioning

confidence: 99%

“…The frequency was set from 1-50 s −1 in steps of 1, and the dynamic amplitude was set at 0.1 mm. 37 Before the test, the area of the sample was determined. The cross-section area of the scaffold sectioned at liquid nitrogen was measured using SEM.…”

Section: Dynamic Mechanical Analysismentioning

confidence: 99%

Ultraporous nanofeatured PCL–PEO microfibrous scaffolds enhance cell infiltration, colonization and myofibroblastic differentiation

Gregersen

Nygaard

et al. 2015

Nanoscale

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In the field of tissue engineering, integration of micro-porosity, nano-topogaphical features and weattability into one three-dimensional (3D) scaffold remains a challenge. The extracellular matrix (ECM) mimicking feature of electrospun fibers endows them wide applications in tissue engineering. However, the tight-packing of electrospun submicron fibers hinder cell infiltration and further colonization. In this study, we fabricated hydrophilic, micro-porous scaffolds with nano-topographical cues by one-step electrospinning, and investigated NIH3T3 fibroblasts cell infiltration, colonization and myofibroblastic differentiation. The hierarchical porosity enhanced cell infiltration and proliferation significantly. Besides, the nano-topography influenced the cell actin distribution and cell morphology that stimulated myofibroblastic differentiation in a drastically different manner from that of traditional solid, smooth electrospun fibers, which may hold great potential in reconstructing tissues that require strong contractile forces.

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Osteoconductive bio-based meshes based on Poly(hydroxybutyrate-co-hydroxyvalerate) and poly(butylene adipate-co-terephthalate) blends

Cited by 15 publications

References 30 publications

Mechanical properties and structure of injection molded poly(hydroxybutyrate‐co‐hydroxyvalerate)/poly(butylene adipate‐co‐terephthalate) (PHBV/PBAT) blends

Mechanical properties and structure of injection molded poly(hydroxybutyrate‐co‐hydroxyvalerate)/poly(butylene adipate‐co‐terephthalate) (PHBV/PBAT) blends

Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix

Ultraporous nanofeatured PCL–PEO microfibrous scaffolds enhance cell infiltration, colonization and myofibroblastic differentiation

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