Osteoconductive composite graft based on bacterial synthesized hydroxyapatite nanoparticles doped with different ions: From synthesis to in vivo studies

Ahmadzadeh, Elham; Talebnia, Farid; Tabatabaei, Meisam; Ahmadzadeh, Hossein; Mostaghaci, Babak

doi:10.1016/j.nano.2016.01.020

Cited by 35 publications

(15 citation statements)

References 29 publications

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“…Several studies have investigated the effectiveness of dopant use in the structure of hydroxyapatite, as well as the use of scaffolds of these materials, aiming its application in tissue engineering [258,[378][379][380]. Dubnika et al [274] produced HAp-Ag scaffolds to act as a local delivery and delivery system for drugs, functionalized with long-term silver ion release rates.…”

Section: Scaffolds For Tissue Engineeringmentioning

confidence: 99%

A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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Hydroxyapatite (HAp) is a bioceramic widely studied due to its chemical similarity with the mineral component of bones. Besides, it is biocompatible, bioactive and thermodynamically stable in the body fluid what poses it as an attractive material for a wide range of applications in the biomedical field. Several efforts have been focused on the synthesis of particles of this material aiming to the precise control of size and morphology, porosity and surface area. HAp is widely used as an implant for bone tissue regeneration, as a coating for metallic implants and in a drug-controlled release. In this sense, the objective of this review is to gather information related to HAp, providing readers with information about synthesis methods, material characteristics and their applications.

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Section: Scaffolds For Tissue Engineeringmentioning

confidence: 99%

A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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“…A bone graft substitute may follow a series of indication and should share a higher number of properties, such as a good material that allows a structural framework for bone growth and the good stem cell to produce new bone [4,5], good cell attachment and the absence of immune reactions. The scaffold is asked to attract osteoprecursor cells, such as bone marrow stem cells (BMSCs), and to induce them to the osteoblastic phenotype (osteoinduction).…”

Section: Introductionmentioning

confidence: 99%

Nanostructured TiO2 Surfaces Promote Human Bone Marrow Mesenchymal Stem Cells Differentiation to Osteoblasts

et al. 2016

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Micro- and nano-patterning/modification are emerging strategies to improve surfaces properties that may influence critically cells adherence and differentiation. Aim of this work was to study the in vitro biological reactivity of human bone marrow mesenchymal stem cells (hBMSCs) to a nanostructured titanium dioxide (TiO2) surface in comparison to a coverglass (Glass) in two different culture conditions: with (osteogenic medium (OM)) and without (proliferative medium (PM)) osteogenic factors. To evaluate cell adhesion, hBMSCs phosphorylated focal adhesion kinase (pFAK) foci were analyzed by confocal laser scanning microscopy (CLSM) at 24 h: the TiO2 surface showed a higher number of pFAK foci with respect to Glass. The hBMSCs differentiation to osteoblasts was evaluated in both PM and OM culture conditions by enzyme-linked immunosorbent assay (ELISA), CLSM and real-time quantitative reverse transcription PCR (qRT-PCR) at 28 days. In comparison with Glass, TiO2 surface in combination with OM conditions increased the content of extracellular bone proteins, calcium deposition and alkaline phosphatase activity. The qRT-PCR analysis revealed, both in PM and OM, that TiO2 surface increased at seven and 28 days the expression of osteogenic genes. All together, these results demonstrate the capability of TiO2 nanostructured surface to promote hBMSCs osteoblast differentiation and its potentiality in biomedical applications.

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“…This phenomenon provided a possibility to load different ions to HA to help both blood clotting and bone formation. Indeed, different ions such as Mg 2+ , Zn 2+ , CO 3 2-have been doped into HA to favor bone formation or even provide anti-bacterial property [25,26]. However, these ions also showed potential to enhance blood clotting in addition to Ca 2+ .…”

Section: Resultsmentioning

confidence: 99%

Hydroxyapatite: a promising hemostatic component in orthopaedic applications

Yin¹,

Zhou²,

Ni³

et al. 2017

Biol Eng Med

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Agent with both great blood clotting activity and bone regeneration ability is deserved to replace conventional bone wax. Recently, hydroxyapatite (HA) has attracted interests from researchers with its both hemostatic and bone healing functions. In present work, the blood clotting activity comparisons of HA to other potential bone repairing materials including calcium silicate, calcium combined attapulgite, calcium tripolyphosphate, and chitosan were carried out to show HA as a recommended hemostatic component to replace bone wax. In addition, the impacts of HA synthesis routes on its blood clotting activity were evaluated, indicating increase of surface area as well as active Ca 2+ of HA can greatly enhance blood clotting. With these attributes, it is expected HA can be a promising component in fabricating hemostatic materials in orthopedic applications as alternatives to bone wax.

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Osteoconductive composite graft based on bacterial synthesized hydroxyapatite nanoparticles doped with different ions: From synthesis to in vivo studies

Cited by 35 publications

References 29 publications

A brief review on hydroxyapatite production and use in biomedicine

A brief review on hydroxyapatite production and use in biomedicine

Nanostructured TiO2 Surfaces Promote Human Bone Marrow Mesenchymal Stem Cells Differentiation to Osteoblasts

Hydroxyapatite: a promising hemostatic component in orthopaedic applications

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