2022
DOI: 10.21638/spbu03.2022.104
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Osteogenic differentiation: a universal cell program of heterogeneous mesenchymal cells or a similar extracellular matrix mineralizing phenotype?

Abstract: Despite the popularity of mesenchymal stem cells (MSCs), many fundamental aspects of their physiology still have not been understood. The information accumulated to date argues that MSCs from different sources vary in their differentiation potential and, probably, in molecular mechanisms of trilineage differentiation. Therefore, this review consists of two parts. Firstly, we focus on the data on inter- and intra-source variation of MSCs. We discuss in detail MSC variation at the single-cell level and direct om… Show more

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Cited by 7 publications
(8 citation statements)
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“…The advantage of the cells, isolated by the described method compared to bone marrow-derived osteoprogenitors, is that the resulting cell population is more homogenous. According to flow cytometry characteristics, there is no contamination of blood-derived cells in OB cultures and one does not need to use sorting after cell isolation, while for bone marrow-derived osteoblasts it is a necessary step [ 18 ]. This makes the described method cheaper and faster.…”
Section: Discussionmentioning
confidence: 99%
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“…The advantage of the cells, isolated by the described method compared to bone marrow-derived osteoprogenitors, is that the resulting cell population is more homogenous. According to flow cytometry characteristics, there is no contamination of blood-derived cells in OB cultures and one does not need to use sorting after cell isolation, while for bone marrow-derived osteoblasts it is a necessary step [ 18 ]. This makes the described method cheaper and faster.…”
Section: Discussionmentioning
confidence: 99%
“…Neither osteopontin, nor periostin and osteocalcin null mice are lethal or display major bone abnormalities [ 16 ]. Type 1 collagen is a key marker of an early proliferation and synthetic phase of osteogenic differentiation [ 18 ]. The requirement of collagen, osteopontin, and periostin at the stage of mineralization may be decreased.…”
Section: Discussionmentioning
confidence: 99%
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“…Although it is generally assumed that osteogenic differentiation of VICs is similar to that of osteoblasts, there is still no empirical confirmation of this assumption because of the lack of multi-omics studies that describe the molecular mechanisms of adult osteoblast differentiation and physiology. 9 Therefore, we aimed to perform the multi-omics comparison of molecular mechanisms of VICs and osteoblast osteogenic differentiation in vitro .…”
Section: Introductionmentioning
confidence: 99%