Osteogenic Effect of High-frequency Acceleration on Alveolar Bone

Alikhani, Mona; Khoo, Edmund; Alyami, Bandar; Raptis, Markos; Salgueiro, J.M.; Oliveira, Serafim M.; Boskey, Adele L.; Teixeira, Cristina

doi:10.1177/0022034512438590

Cited by 52 publications

(59 citation statements)

References 29 publications

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“…Six studies applied in vivo micro-CT, performed in the maxilla [6], [15], [20], [21] and in the condyle [10], [22]. The scanning device which was most often used was the μCT 40 (Scanco Medical, Brüttisellen, Switzerland) [9], [11], [13], [14], [19], [23], [24], [25], [26], [27], [28], [29], [30], [31], followed by the Skyscan apparatus (Skyscan, Aartselaar, Belgium) [3], [4], [8], [20], [21], [32], [33], [34], [35]. The results of the quantitative analysis are presented in Table 2, Table 3, Table 4.…”

Section: Resultsmentioning

confidence: 99%

“…With regard to the maxillofacial bone and teeth, micro-CT analysis has been mainly used to evaluate alveolar bone remodelling [3], [4], [5], the dynamic changes in periodontal ligament thickness [6] as well as specific osseous sites in the cortical and trabecular bone compartment [7], [8], [9], [10], [11], [12], [13]. However, many of such studies have used micro-CT imaging analyses without detailed description of the applied methodological parameters such as region of interest, the histograms of grey level, the scripts used in the analysis software and the outcome variables.…”

Section: Introductionmentioning

confidence: 99%

“…Bagi et al (2011) have described the physiological aspects of the jaw bone anatomy by means of micro-CT imaging, but with description of the cancellous and cortical bone parameters solely for the mandible. Besides the aforementioned papers, other original animal studies made use of the micro-CT technique for assessing the rodent jaw bone architecture in diverse conditions, including the evaluation of changes in bone volume, mass and micro-architecture in response to mechanical loading [9], [14] or to the animal's systematic status such as osteoporosis [8], [15] and diabetes [16]. When analysing the methodological approaches used in these studies, only Abtahi et al (2013) and Kuroshima et al (2013) have followed the ARRIVE guidelines.…”

Section: Introductionmentioning

confidence: 99%

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Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

et al. 2015

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IntroductionKnowledge about macro- and micro-structural characteristics may improve in vivo estimation of the quality and quantity of regenerated bone tissue. For this reason, micro-CT imaging has been applied to evaluate alveolar bone remodelling, alterations of periodontal ligament thickness and cortical and trabecular bone changes in rodent jaw bones. In this paper, we provide a systematic review on the available micro-CT literature on jaw bone micro-architecture.MethodologyA detailed search through the PubMed database was performed. Articles published up to December 2013 and related to maxilla, mandible and condyle with quantitatively analysed bone micro-architectural parameters were considered eligible for inclusion. Two reviewers assessed the search results according to inclusion criteria designed to identify animal studies quantifying the bone micro-architecture of the jaw rodent bones in physiological or drug-induced disease status, or in response to interventions such as mechanical loading, hormonal treatment and other metabolic alterations. Finally, the reporting quality of the included publications was evaluated using the tailored ARRIVE guidelines outlined by Vignoletti and Abrahamsson (2012).ResultsDatabase search, additional manual searching and assessment of the inclusion and exclusion criteria retrieved 127 potentially relevant articles. Eventually, 14 maxilla, 20 mandible and 12 condyle articles with focus on bone healing were retained, and were analysed together with 3 methodological papers. Each study was described systematically in terms of subject, experimental intervention, follow-up period, selected region of interest used in the micro-CT analysis, parameters quantified, micro-CT scanner device and software. The evidence level evaluated by the ARRIVE guidelines showed high mean scores (between 18 and 25; range: 0–25), indicating that most of the selected studies are well-reported. The major obstacles identified were related to sample size calculation, absence of adverse event descriptions, randomization or blinding procedures.ConclusionsThe evaluated studies are highly heterogeneous in terms of research topic and the different regions of interest. These results illustrate the need for a standardized methodology in micro-CT analysis. While the analysed studies do well according to the ARRIVE guidelines, the micro-CT procedure is often insufficiently described. Therefore we recommend to extend the ARRIVE guidelines for micro-CT studies.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

et al. 2015

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“…We hypothesize that controlled micro-trauma in the form of micro-osteoperforations (MOPs; which maintain the integrity and architecture of hard and soft tissue) will amplify the expression of inflammatory markers that are normally expressed during orthodontic treatment and that this amplified response will accelerate both bone resorption and tooth movement. To test our hypothesis we used MOPs in an animal model of accelerated tooth movement (7) , followed by human clinical trials of the MOPS protocol (8,9).…”

Section: Accelerating Tooth Movementmentioning

confidence: 99%

Micro-osteoperforations: Minimally invasive accelerated tooth movement

Alikhani

Alansari

Sangsuwon

et al. 2015

Seminars in Orthodontics

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“…They have shown that vibratory signals promote bone formation, enhance bone density and attenuate the negative effects associated with catabolic stimuli 7–11 . An anabolic response has also been observed in craniofacial structures 12,13 including the alveolar bone 14 .…”

Section: Introductionmentioning

confidence: 95%

Effect of cyclical forces on the periodontal ligament and alveolar bone remodeling during orthodontic tooth movement

Kalajzić

Peluso²,

Utreja

et al. 2013

The Angle Orthodontist

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Objective To investigate the effect of externally applied cyclical (vibratory) forces on the rate of tooth movement, the structural integrity of the periodontal ligament, and alveolar bone remodeling. Methods Twenty-six female Sprague-Dawley rats (7 weeks old) were divided into four groups: CTRL (unloaded), VBO (molars receiving a vibratory stimulus only), TMO (molars receiving an orthodontic spring only), and TMO+VB (molars receiving an orthodontic spring and the additional vibratory stimulus). In TMO and TMO+VB groups, the rat first molars were moved mesially for 2 weeks using Nickel-Titanium coil spring delivering 25 g of force. In VBO and TMO+VB groups, cyclical forces at 0.4 N and 30 Hz were applied occlusally twice a week for 10 minutes. Microfocus X-ray computed tomography analysis and tooth movement measurements were performed on the dissected rat maxillae. Tartrate-resistant acid phosphatase staining and collagen fiber assessment were performed on histological sections. Results Cyclical forces significantly inhibited the amount of tooth movement. Histological analysis showed marked disorganization of the collagen fibril structure of the periodontal ligament during tooth movement. Tooth movement caused a significant increase in osteoclast parameters on the compression side of alveolar bone and a significant decrease in bone volume fraction in the molar region compared to controls. Conclusions Tooth movement was significantly inhibited by application of cyclical forces.

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Osteogenic Effect of High-frequency Acceleration on Alveolar Bone

Abstract: A supplemental appendix to this article is published electronically only at http://jdr.sagepub.com/supplemental.

Cited by 52 publications

References 29 publications

Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

Micro-osteoperforations: Minimally invasive accelerated tooth movement

Effect of cyclical forces on the periodontal ligament and alveolar bone remodeling during orthodontic tooth movement

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