Osteogenic Melanoma With Desmin Expression

Abstract

The importance of recognizing osteogenic melanoma is based on difficulties for histologic recognition and its differentials diagnosis.

Bone Formation in Cutaneous Nodules on the Leg: A Quiz

“…Urmacher described bone formation in a recurrent desmoplastic melanoma from the retroauricular area (1). There have been fewer than 30 cases of OM reported to date, the vast majority of them in acral skin (2). Subungueal localization is common and there is no sex predilection (2).…”

“…There have been fewer than 30 cases of OM reported to date, the vast majority of them in acral skin (2). Subungueal localization is common and there is no sex predilection (2). Histologically different osteoid patterns may occur, including large sheets of reticulated matrix, trabeculae, islands rimmed by malignant cells and delicate foci of lace-like osteoid matrix within sheets of tumour cells (3).…”

“…There are different theories regarding this phenomenon. One theory explains osteoid formation as a response to prior trauma, such as previous re-sectioning (2,5). As various OMs are seen in de novo lesions this theory is questionable.…”

“…Osteogenic transformation may occur in several benign and malignant skin tumours (2). Benign conditions with osteogenic metaplasia that mimic malignant neoplasms include myositis ossificans, bizarre parosteal osteocartilaginous proliferation, atypical exostosis and fibro-osseous pseudotumour of the digits (2).…”

“…Osteogenic transformation may occur in several benign and malignant skin tumours (2). Benign conditions with osteogenic metaplasia that mimic malignant neoplasms include myositis ossificans, bizarre parosteal osteocartilaginous proliferation, atypical exostosis and fibro-osseous pseudotumour of the digits (2). Osteosarcoma (OS) is the most important differential diagnosis for OM among malignant neoplasms, as these entities share several histological features (2).…”