Osteogenic Sarcoma Occurring in Fragilitas Ossium

Osteogenic sarcoma complicating osteogenesis imperfecta tarda

“…A s s u m i n g s y n t r o p i s m a n d a s s u m i n g a causal r e l a t i o n s h i p b e t w e e n the two disorders, multiple fractures a n d i m p l a n t a t i o n of metallic osteosynthetic devices have b e e n i n c r i m i n a t e d as precipitating factors [5]. Neither of these e x p l a n a t i o n s can be valid in the 49 years Figures 3 and 4 old patient of Jewell and Lofstrom [3], in whom the previously unfractured os ileum was the primary site. The tumor in the female patient of Klenerman [5] was diagnosed when she was 8 years old, an intramedullary nail having been inserted in the right proximal femur 41/2 years earlier.…”

“…of a m o r e t h a n c o i n c i d e n t a l c o n c u r r e n c e , c a n n o t be a n s w e r e d [3,8]. A s s u m i n g s y n t r o p i s m a n d a s s u m i n g a causal r e l a t i o n s h i p b e t w e e n the two disorders, multiple fractures a n d i m p l a n t a t i o n of metallic osteosynthetic devices have b e e n i n c r i m i n a t e d as precipitating factors [5].…”

“…Occasionally, one observes development of a hyperplastic callus, which radiologically may mimic osteogenic sarcoma [1,6]. However, histologically proven osteogenic sarcoma in osteogenesis imperfecta has been reported in only four cases [3,4,5].…”

Osteosarcoma occurring in osteogenesis imperfecta

“…There have been only nine reported cases in the world literature (Table 1) [2,5,8,9,10,11,18,19], and most authors concluded that osteosarcoma in the setting of OI occurred as a sporadic, rather than a related, event. More important, however, is the fact that osteosarcoma is difficult to diagnose in patients with OI, which was Factors that have been proposed as possible etiological agents in primary bone tumors are radiation, viruses, chemical carcinogens, metal implants, and trauma [17].…”

Osteogenesis imperfecta and hyperplastic callus formation in a family: a report of three cases and a review of the literature

“…At this moment, however, little is known about the condition. The imaging and histological similarity of this hyperplastic callus formation to an osteogenic sarcoma raises great concern among orthopedic surgeons [2][3][4]7,9,10,12,14,[16][17][18][19][20][21][22][23][24][25]. The imaging and histological similarity of this hyperplastic callus formation to an osteogenic sarcoma raises great concern among orthopedic surgeons [2][3][4]7,9,10,12,14,[16][17][18][19][20][21][22][23][24][25].…”