Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats

Alghamdi, Hamdan S.; Bosco, Ruggero; Beucken, Jeroen J.J.P. van den; Walboomers, X. Frank; Jansen, John A.

doi:10.1016/j.biomaterials.2013.02.033

Cited by 95 publications

(71 citation statements)

References 61 publications

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“…We used a dorsal approach similar to the procedure described by Alghamdi et al [43]. Buprenorphine (Temgesic ® , Reckitt Benckiser AG, Wallisellen, Switzerland) was administered subcutaneously before surgery and every 8 h for the first 48 h after surgery for pain relief.…”

Section: Ovariectomymentioning

confidence: 99%

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Kettenberger

Ston

Thein³

et al. 2014

Biomaterials

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a b s t r a c tBisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formation and resorption in an ovariectomized rat femoral model. A cross-linked hyaluronic acid hydrogel was loaded with the drug and applied bilaterally in predrilled holes before inserting polymer screws. Static and dynamic bone parameters were analyzed based on in vivo microCT scans performed first weekly and then biweekly. The results showed that the locally released Zoledronate boosted bone formation rate up to 100% during the first 17 days after implantation and reduced the bone resorption rate up to 1000% later on. This shift in bone remodeling resulted in an increase in bone volume fraction (BV/TV) by 300% close to the screw and 100% further away. The double effect on bone formation and resorption indicates a great potential of Zoledronateloaded hydrogel for enhancement of peri-implant bone volume which is directly linked to improved implant fixation.

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Section: Ovariectomymentioning

confidence: 99%

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Kettenberger

Ston

Thein³

et al. 2014

Biomaterials

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“…The second form of collagen scaffold is the nanofiber sheets 18,19 . The third form of collagen scaffold is the nanocomposites with inorganic phases like calcium phosphate mineral [20][21][22][23] . The main disadvantage of collagen as a material is the poor mechanical properties, which limit its applications.…”

Section: Introductionmentioning

confidence: 99%

Extraction and Characterization of Collagen from Buffalo Skin for Biomedical Applications

Rizk¹,

Mostafa²

2016

Orient. J. Chem

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Collagen is widely used for biomedical and pharmaceutical applications due to its excellent biocompatibility, biodegradability and weak antigenicity. However, applicability is limited due to its high cost and probability of disease transmission from the current sources, which are bovine and porcine. In the present study, collagen was extracted from 6 months buffalo skins as alternative save sources. Collagen was characterized by different physico-chemical techniques like ATR-FTIR, Raman, SEM, DSC and amino acids analysis. Proline and hydroxyproline contents of buffalo skin collagen were higher than those of calf skin collagen. Thermal stability of buffalo skin collagen is high with respect to that of calf skin collagen. The obtained buffalo skin collagen shows higher stiffness upon cross-linking with glutaraldehyde. Thus buffalo skin collagen can be used for fabrication of high strength bioactive sponge and sheets for medical applications, like scaffold for tissue engineering, drug delivery and wound dressing system.

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“…biphosphonates) or anabolic agents (i.e. parathyroid hormone or bone morphogenetic protein) immobilised on the material surface in the osteoporotic condition, but, to the best of the authors' knowledge, few published papers have evaluated material surface functionalisation with collagen type I in an osteoporotic animal model [21,22].…”

Section: Discussionmentioning

confidence: 98%

“…For example, Stadlinger et al [22] found no detectable impact on the osteointegration parameter (BIC, BI and BV/TV and pull-out test) exerted by a collagen/chondroitin sulphate titanium coating at either two or four weeks after implant. In another in vivo study, Alghamdi et al [21] compared a CaP and collagen type I coated Ti implant to an uncoated one both in healthy and osteoporotic conditions, by adopting a similar experimental set up. Twelve weeks after implantation, the BV parameter measured with microtomography revealed no differences between coated and uncoated materials in either the SHAM or the OVX group.…”

Section: Discussionmentioning

confidence: 98%

Collagen type I coating stimulates bone regeneration and osteointegration of titanium implants in the osteopenic rat

Sartori

Giavaresi

Parrilli

et al. 2015

International Orthopaedics (SICOT)

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Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats

Cited by 95 publications

References 61 publications

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Extraction and Characterization of Collagen from Buffalo Skin for Biomedical Applications

Collagen type I coating stimulates bone regeneration and osteointegration of titanium implants in the osteopenic rat

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