Osteoking Promotes Bone Formation and Bone Defect Repair through ZBP1-STAT1-PKR-MLKL-mediated Necroptosis
Zhang Suya,
Yudong Liu,
Zhaochen Ma
et al.
Abstract:Background: Osteoking has been used for fracture therapy with a satisfying clinical efficacy. However, its therapeutic properties and the underlying mechanisms remain elusive.
Method: A bone defect rat model was established to evaluate the pharmacological effects of Osteoking by the dynamic observation of X-ray, micro-CT and histopathologic examination. Transcriptome profiling was performed to identify bone defect-related genes and Osteoking effective targets. Then, a "disease-related gene-drug target" interac… Show more
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