Osteomyelitis caused by Veillonella

Barnhart, Richard A.; Weitekamp, Michael R.; Aber, Robert C.

doi:10.1016/0002-9343(83)91083-5

Cited by 31 publications

(20 citation statements)

References 9 publications

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“…The infection responded to a 3-week course of intravenous Amoxicillin (12 g/day) followed by 8 weeks of oral Amoxicillin (6 g/day). Barnhart [20] reported on a 31-year-old male who presented with a postoperative Veillonella infection in the cervical spine. The portal of entry was probably the post-operative oesophageal perforation that had occurred.…”

Section: Discussionmentioning

confidence: 99%

Veillonella spondylodiscitis in a healthy 76-year-old lady

et al. 2011

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Purpose To report a case of Veillonella spondylodiscitis in a healthy 76-year-old lady. Methods A previously healthy 76-year-old lady presented with worsening axial back pain at the thoracolumbar junction, fever and loss of weight. Examination revealed deep tenderness over the thoracolumbar junction with painful and restricted spinal movements. The lower limb motor power, sensation and reflexes were normal. Results Radiographs of the lumbosacral spine showed evidence of spinal instability with lateral translation and loss of disc space at L1-L2. MRI scans revealed fluid intensity within the L1-L2 disc with infective debris elevating the posterior longitudinal ligament and narrowing the spinal canal. Both tissue and blood cultures were positive for the anaerobic organism, Veillonella. A staged anterior-posterior spinal surgery followed by an extended course of antibiotics resulted in the clinical improvement and normalisation of blood parameters. A review of the literature on Veillonella infections is also presented. Conclusion The aim of this report is to bring Veillonella spondylodiscitis to the attention of spinal surgeons and infectious disease specialists and discuss the management options.

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Section: Discussionmentioning

confidence: 99%

Veillonella spondylodiscitis in a healthy 76-year-old lady

et al. 2011

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“…Currently, the genus Veillonella is subdivided into 13 species: V. atypica, V. caviae, V. criceti, V. denticariosi, V. dispar, V. magna, V. montpellierensis, V. parvula, V. ratti, V. rodentium, V. rogosae, V. seminalis, and V. tobetsuensis (10)(11)(12)(13)(14)(15)(16)(17). These Veillonella species have been isolated from lesions associated with endocarditis (18)(19)(20)(21), hepatic abscesses (22), meningitis (23), osteomyelitis (24), acute pyelonephritis, secondary bacteremia during pregnancy (25), opportunistic infections (26)(27)(28), and prosthetic joint infection (29). Additionally, these bacteria, like other anaerobes, are susceptible to various antimicrobials; however, several of these species are resistant to tetracycline.…”

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confidence: 99%

Interaction between Streptococcus spp. and Veillonella tobetsuensis in the Early Stages of Oral Biofilm Formation

Mashima¹,

Nakazawa²

2015

J. Bacteriol.

111

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Dental plaque is a multispecies oral biofilm, the development of which is initiated by adherence of the pioneer Streptococcus spp. Oral Veillonella spp., including V. atypica, V. denticariosi, V. dispar, V. parvula, V. rogosae, and V. tobetsuensis, are known as early colonizers in oral biofilm formation. These species have been reported to coaggregate with Streptococcus spp. in a metabolic cooperation-dependent manner to form biofilms in human oral cavities, especially in the early stages of biofilm formation. However, in our previous study, Streptococcus gordonii showed biofilm formation to the greatest extent in the presence of V. tobetsuensis, without coaggregation between species. These results suggest that V. tobetsuensis produces signaling molecules that promote the proliferation of S. gordonii in biofilm formation. It is well known in many bacterial species that the quorum-sensing (QS) system regulates diverse functions such as biofilm formation. However, little is known about the QS system with autoinducers (AIs) with respect to Veillonella and Streptococcus spp. Recently, autoinducer 1 (AI-1) and AI-2 were detected and identified in the culture supernatants of V. tobetsuensis as strong signaling molecules in biofilm formation with S. gordonii. In particular, the supernatant from V. tobetsuensis showed the highest AI-2 activity among 6 oral Veillonella species, indicating that AIs, mainly AI-2, produced by V. tobetsuensis may be important factors and may facilitate biofilm formation of S. gordonii. Clarifying the mechanism that underlies the QS system between S. gordonii and V. tobetsuensis may lead to the development of novel methods for the prevention of oral infectious diseases caused by oral biofilms. Bacteria exist as multispecies communities in nature, and signaling among the cells is thought to be a part of the community dynamics. A biofilm is a community of bacteria attached to a substratum or surface. The bacteria in biofilms are embedded in an extracellular polymeric matrix produced by the bacteria themselves. Bacteria develop biofilms on submerged surfaces such as natural aquatic systems, water pipes, living tissues, tooth surfaces, indwelling medical devices, and implants (1). When bacteria succeed in forming a biofilm within a human host, they become highly resistant to antimicrobial treatment (2). Human dental plaque is a well-recognized example of a natural biofilm that plays an important role in the development and pathogenesis of oral diseases such as caries, gingivitis, and periodontitis (3).The human oral cavity contains more than 19,000 phylotypes of microbial species (4), and approximately 100 to 200 species are found in a single individual (5). Dental plaque is a multispecies biofilm, the development of which is initiated by the adherence of pioneer species to the salivary proteins and glycoproteins adsorbed on tooth enamel. The biofilm is not formed by random simultaneous colonization by these species but rather by selective, reproducible, sequential colonization (6, 7).ThegenusVei...

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“…Little has been written about the occurrence of Veillonella in infections, and it is difficult to evaluate the prevalence and clinical importance of Veillonella species, which are rare causes for serious infections such as meningitis, osteomyelitis, prosthetic joint infection, pleuropulmonary infection, endocarditis, and bacteremia. 10,11,12,13,14,15,16,17,18,19,20 We performed a MEDLINE search using the keywords "Veillonella infection", "anaerobic osteomyelitis", "anaerobic epidural abscess", and "anaerobic spine infection" to search for reports/studies on spine infection caused by Veillonella species, and found only seven cases (Table 1). 11,12,13,14,15,16,17 Including the present case, the median age of the patients infected was 57.8 years (range: 27e76 years).…”

Section: Discussionmentioning

confidence: 99%

“…11,13,14,15,17 Except one case with cervical spine infection, 15 the remaining cases had lumbar spine infections. Except one case with odynophagia, 15 all the other cases had chronic low back pain with the durations ranging from 1 week to 4 months. Veillonella spinal infection seems to be having an insidious and subacute course.…”

Section: Discussionmentioning

confidence: 99%

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Epidural abscess caused by Veillonella parvula: Case report and review of the literature

Chen¹,

Ko²,

Yang³

et al. 2016

Journal of Microbiology, Immunology and Infection

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Veillonella parvula, an anaerobic, Gram-negative coccus is part of the normal flora of the oral, gastrointestinal, respiratory, and genitourinary tracts in humans and animals. We herein present a case of epidural abscess caused by V. parvula in a 68-year-old man with sinus squamous cell carcinoma who presented with a 3-week history of low back pain. Blood and pus cultures were positive for Veillonella spp. After sequencing of the 16S ribosomal DNA, the pathogen was identified as V. parvula. Surgical debridement was performed following which the patient received intravenous administration of amoxicillin/clavulanate. To our knowledge, there are only seven reported cases of spinal infection caused by Veillonella spp. and these are reviewed here.

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Osteomyelitis caused by Veillonella

Cited by 31 publications

References 9 publications

Veillonella spondylodiscitis in a healthy 76-year-old lady

Veillonella spondylodiscitis in a healthy 76-year-old lady

Interaction between Streptococcus spp. and Veillonella tobetsuensis in the Early Stages of Oral Biofilm Formation

Epidural abscess caused by Veillonella parvula: Case report and review of the literature

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