Osteomyelitis, discitis, epidural and psoas abscess secondary to<i>Salmonella enterica</i>in a man with diabetes mellitus and newly diagnosed α-thalassaemia trait

Farrar, H.K.; Abbey, Aoife; Patel, Vinod; Nair, Rajiv

doi:10.1136/bcr-2014-207008

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…Nonetheless, the heterogenic clinical presentation is seldom limited to this population alone. The variation present in this study, 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 consistent with overall spinal infection cases, urges additional research within other subsets to construct reliable diagnosis patterns. Because this is the first systematic review of PSI in a previously unexplored population, its purpose is to supplement the aforementioned goal of ultimately guiding clinical decision making for PSI patient populations.…”

Section: Discussionmentioning

confidence: 64%

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

et al. 2023

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Purpose: Primary spinal infections (PSIs) are a group of infectious diseases characterized by inflammation of the end plate-disk unit or its surroundings. PSI is considered more prevalent and aggressive among patients with chronic immunocompromised states. Association of PSIs, immunocompromising cancers, and hemoglobinopathies has not been systematically analyzed. We conducted a systematic review to study characteristics, clinical presentation, and mortality of patients with PSI in the setting of hematologic disease. Methods: A systematic literature search in PubMed, Web of Science, and Scopus was conducted in April 2022 in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included retrospective case series and individual case reports. Results: On careful review, 28 articles published between 1970 and 2022 were selected. These studies featured 29 patients who met inclusion criteria (mean age 29 years, age range 1.5 to 67 years; 63.3% male). Lumbar infection was the most common location (65.5%), with Salmonella (24.1%) as the main causative microorganism. Neurologic compromise was present in 41% of patients, and surgical intervention occurred in 48.3%. Average antibiotic duration was 13 weeks. The postoperative complication rate was 21.4%, with a mortality of 6.9%. Conclusion: PSI in patients with hematologic disease, while having shorter periods to diagnosis, presents increased rates of neurologic deficit, surgical intervention, and complications.

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Section: Discussionmentioning

confidence: 64%

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

et al. 2023

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“…In one series of Salmonella osteomyelitis, 60 patients were noted to have hemoglobinopathies; 2 had sickle-thalassemia and 1 had sickle cell trait [5]. Additional case reports of patients with Salmonella osteomyelitis with thalassemia [6,7], thalassemia trait [8,9], sickle-thalassemia [[10], [11], [12], [13]], or sickle cell trait [14] have been reported.…”

Section: Discussionmentioning

confidence: 99%

Salmonella enterica serovar Typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: A possible association

Stephanie

Schmalzle

2019

IDCases

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Salmonella osteomyelitis is known to occur in immunocompromised and sickle cell disease patients. It rarely occurs in other hosts. We present a case of chronic femoral osteomyelitis due to S. enterica serovar Typhi seen in a Maryland resident. Potential risk factors included traveling to an endemic area as well as a newly diagnosed sickle cell trait and thalassemia trait. It is postulated that less severe hemoglobinopathies may also contribute to an elevated risk of Salmonella osteomyelitis.

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“…7 There has been an increase in Salmonella-induced spondylitis in recent years. 6,[8][9][10][11][12][13][14][15][16] Spondylitis caused by Salmonella enteritis and B. melitensis has not been reported to date. An unusual mixed infection characterizes this case.…”

Section: Spinal Infection Is Classified As Specific Infection (B Meli...mentioning

confidence: 99%

Salmonella enteritis Spondylitis with Brucella melitensis Infection: A Rare Case of Mixed Infections of Spine

Zhang¹,

Wang²,

Zhang³

et al. 2022

IDR

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Background: As a widespread back condition in orthopedics, spondylitis is rarely caused by Salmonella. Here, we report a rare case of spondylitis caused by Salmonella enteritis associated with Brucella melitensis. Case Presentation: Salmonella septicemia was initially diagnosed in a 27-year-old woman with high fever and low back pain, but her symptoms did not improve after 3 days of antibiotic treatment. The patient was then referred to our hospital's Department of Infectious Diseases. This patient had mild anemia. There were no positive results for tuberculosis antibody and Rose Bengal plate agglutination (RBPT). When the patient's symptoms did not improve after diagnostic anti-tuberculosis treatment, he was transferred to our Orthopaedics department for lumbar posterior lesion removal, decompression, internal fixation, cage implantation, and bone grafting fusion under general anesthesia. Following the operation, a postoperative specimen culture and a real-time polymerase chain reaction (real-time-PCR) indicated Salmonella enteritis with Brucella melitensis (B. melitensis) infection. The symptoms improved and inflammatory markers returned to normal after 2 weeks of treatment with levofloxacin, rifampicin, and doxycycline. Conclusion: Anaemic patients with immunocompromised conditions should be given special attention in the diagnosis of Salmonella spondylitis. Surgery should be considered if antibiotic therapy fails to identify the pathogen that is infecting the patient with infectious spondylitis.

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Osteomyelitis, discitis, epidural and psoas abscess secondary toSalmonella entericain a man with diabetes mellitus and newly diagnosed α-thalassaemia trait

Abstract: We report the case of a 65-year-old man with type 2 diabetes mellitus and α-thalassaemia trait. Investigations for relapsing and remitting fever found vertebral osteomyelitis, discitis and epidural and psoas abscess secondary toSalmonella enterica.

Cited by 8 publications

References 10 publications

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

Primary Spinal Infections in Patients With Hematologic Immunocompromising Conditions: A Systematic Literature Review

Salmonella enterica serovar Typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: A possible association

Salmonella enteritis Spondylitis with Brucella melitensis Infection: A Rare Case of Mixed Infections of Spine

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