Osteomyelitis treated with gentamicin-PMMA beads: 100 patients followed for 1–12 years

Walenkamp, G. H. I. M.; Kleijn, L. L. A.; Leeuw, Marion de

doi:10.3109/17453679808997790

Cited by 158 publications

(102 citation statements)

References 8 publications

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“…Still more important may be the local administration of antibiotics. This method of drug delivery has been used in the management of infected bone because much higher drug concentrations can be achieved in the affected bone tissue without reaching toxic serum levels [14,28,29]. In the case of rifampicin, this means that when applied topically, the local concentration in the bone tissue is expected to exceed the harmful level of 7 pg/ml.…”

Section: Discussionmentioning

confidence: 99%

Toxic effect of rifampicin on human osteoblast‐like cells

Isefuku

Joyner

Simpson

2001

Journal Orthopaedic Research

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We examined the effects of rifampicin on osteoblast-like cells derived from adult human bone in vitro. Cancellous bone was collected from five different individuals during elective orthopaedic operations and cultured in antibiotic-free media. Total DNA, 'H-thymidine incorporation and alkaline phosphatase (ALP) activity were measured after the cells were cultured for 4 days in media containing concentrations of rifampicin ranging from 0 to 1000 pg/ml. Mean total DNA was decreased at concentrations of 10 pglml and above in the cultures obtained from four out of five individuals but these decreases were significant in the cultures from only two individuals. 'H-thymidine incorporation, a more sensitive indicator of change in cell proliferation, and ALP activity were significantly decreased ( P < 0.05) in all of the cultures containing 3 and 7 pginil, respectively. In the clinical setting, serum concentrations of rifampicin often exceed 10 pglml after systemic administration. The present study has shown that rifampicin, at these concentrations. can inhibit the proliferation of osteoblast-like cells in vitro. Further studies should be carried out to assess whether rifampicin is detrimental to the bone repair process in vivo.

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Section: Discussionmentioning

confidence: 99%

Toxic effect of rifampicin on human osteoblast‐like cells

Isefuku

Joyner

Simpson

2001

Journal Orthopaedic Research

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“…Various antibiotic-eluting devices and materials have been reported in joint arthroplasty, such as nondegradable materials like spacer beads and polymethylmethacrylate bone cements, titanium implants, [15][16][17] biodegradable materials such as poly-(lactide-co-glycolide) copolymers, [18][19][20] polycaprolactone, 21,22 polyanhydrides, 23,24 polyhydroxybutyrate-co-hydroxyvalerate 25,26 and polyhydroxyalkanoates 27 and natural polymers such as collagen 28,29 and chitosan. 30,31 Titanium and titanium alloys are widely used as orthopedic implants due to their ideal mechanical properties and satisfactory biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits

Liu¹,

He²,

Liu³

et al. 2017

IJN

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Titanium and titanium alloy are widely used as orthopedic implants for their favorable mechanical properties and satisfactory biocompatibility. The aim of the present study was to investigate the antibacterial effect and bone cell biocompatibility of a novel implant made with nanotubular anodized titanium coated with gentamicin (NTATi-G) through in vivo study in rabbits. The animals were divided into four groups, each receiving different kinds of implants, that is, NTATi-G, titanium coated with gentamicin (Ti-G), nanotubular anodized titanium uncoated with gentamicin (NTATi) and titanium uncoated with gentamicin (Ti). The results showed that NTATi-G implant prevented implant-related osteomyelitis and enhanced bone biocompatibility in vivo. Moreover, the body temperature of rabbits in NTATi-G and Ti-G groups was lower than those in Ti groups, while the weight of rabbits in NTATi-G and Ti-G groups was heavier than those in NTATi and Ti groups, respectively. White blood cell counts in NTATi-G group were lower than NTATi and Ti groups. Features of myelitis were observed by X-ray films in the NTATi and Ti groups, but not in the NTATi-G and Ti-G groups. The radiographic scores, which assessed pathology and histopathology in bone tissues, were significantly lower in the NTATi-G and Ti-G groups than those in the NTATi and Ti groups, respectively ( P <0.05). Meanwhile, explants and bone tissue culture demonstrated significantly less bacterial growth in the NTATi-G and Ti-G groups than in the NTATi and Ti groups, respectively ( P <0.01). The bone volume in NTATi-G group was greater than Ti-G group, and little bone formation was seen in NTATi and Ti groups.

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“…The beads are typically left in the wound for 5 to 14 days after debridement or until soft tissure coverage or primary closure can be achieved. 13 Studies have shown that minimum inhibitory concentration of antibiotics are released from PMMA beads from the first 2 days after implantation up to multiple weeks. 12 Following proper debridement and antibiotic prophylaxis, a Ceretec bone scan, which is a sensitive and specific for osteomyelitis, can be utilized to confirm the absence of infection or persistent infection.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case Report of Two Bone Osteomyelitis With Long-Term Follow-up

Carpenter¹,

Taylor²,

Motley³

et al. 2008

FAOJ

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Osteomyelitis is traditionally subdivided into three categories based on etiology. The first type is hematogenous osteomyelitis. This form is commonly monomicrobial, with staphylococcal organisms isolated most frequently. 7 The second type is direct extension osteomyelitis. It is usually polymicrobial in origin and seen more frequently in the general population. 6 Sources of direct extension osteomyelitis include puncture wounds, surgery, implants, contiguous ulcerations, and septic arthritis.

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Osteomyelitis treated with gentamicin-PMMA beads: 100 patients followed for 1–12 years

Cited by 158 publications

References 8 publications

Toxic effect of rifampicin on human osteoblast‐like cells

Toxic effect of rifampicin on human osteoblast‐like cells

Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits

An Unusual Case Report of Two Bone Osteomyelitis With Long-Term Follow-up

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