2024
DOI: 10.3390/biomedicines12071527
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Osteopontin: A Key Multifaceted Regulator in Tumor Progression and Immunomodulation

Venketesh K. Panda,
Barnalee Mishra,
Angitha N. Nath
et al.

Abstract: The tumor microenvironment (TME) is composed of various cellular components such as tumor cells, stromal cells including fibroblasts, adipocytes, mast cells, lymphatic vascular cells and infiltrating immune cells, macrophages, dendritic cells and lymphocytes. The intricate interplay between these cells influences tumor growth, metastasis and therapy failure. Significant advancements in breast cancer therapy have resulted in a substantial decrease in mortality. However, existing cancer treatments frequently res… Show more

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