Osteopontin is an important mediator of alcoholic liver disease<i>via</i>hepatic stellate cell activation

Seth, Devanshi; Duly, Alastair; Kuo, Paul C.; McCaughan, Geoffrey W.; Haber, Paul S.

doi:10.3748/wjg.v20.i36.13088

Cited by 46 publications

(39 citation statements)

References 45 publications

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“…In fact, there is an association between the severity of hepatic inflammation and fibrosis and the HVPG even before cirrhosis develops [23] . Longitudinal studies are needed to assess whether OPN, as a key mediator of the alcohol-induced effects on hepatic stellate cell functions and liver fibrogenesis [24] , could give similar information.…”

mentioning

confidence: 99%

Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis

Brůha

Jáchymová

Petrtýl

et al. 2016

WJG

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mentioning

confidence: 99%

Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis

Brůha

Jáchymová

Petrtýl

et al. 2016

WJG

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“…Serum and hepatic OPN levels are increased in patients with AH and correlate with disease severity and short term mortality (Affo et al, 2013; Morales-Ibanez et al, 2013; Patouraux et al, 2012; Seth et al, 2014). OPN gene knockout reduced chronic-plus-binge ethanol-induced liver steatosis, inflammation and injury (Morales-Ibanez et al, 2013).…”

Section: Pro-inflammatory Cytokines and Chemokinesmentioning

confidence: 99%

Targeting inflammation for the treatment of alcoholic liver disease

Zhou

Parker

et al. 2017

Pharmacology & Therapeutics

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Alcoholic liver disease (ALD) is a leading cause of chronic liver disease with a wide spectrum of manifestations including simple steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Liver injury in ALD is caused by chronic inflammation, which has been actively investigated as a therapeutic target for the treatment of ALD for over the last four decades. In this review, we summarize a wide variety of inflammatory mediators that have been shown to contribute to the pathogenesis of ALD, and discuss the therapeutic potential of these mediators for the treatment of ALD.

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“…CD44, a type I transmembrane glycoprotein with over 20 different isoforms, has been demonstrated to be involved in liver disease and inflammation. Patients with ALD, including alcoholic steatosis, alcoholic hepatitis, and alcoholic cirrhosis, in fact have elevated CD44 expression [66]. The canonical CD44 ligand is hyaluronic acid (HA).…”

Section: The Ecmmentioning

confidence: 99%

Transitional Remodeling of the Hepatic Extracellular Matrix in Alcohol-Induced Liver Injury

Poole

Arteel

2016

BioMed Research International

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Alcohol consumption is a common custom worldwide, and the toxic effects of alcohol on several target organs are well understood. The liver is the primary site of alcohol metabolism and is therefore the major target of alcohol toxicity. Alcoholic liver disease is a spectrum of disease states, ranging from simple steatosis (fat accumulation), to inflammation, and eventually to fibrosis and cirrhosis if untreated. The fibrotic stage of ALD is primarily characterized by robust accumulation of extracellular matrix (ECM) proteins (collagens) which ultimately impairs the function of the organ. The role of the ECM in early stages of ALD is poorly understood, but recent research has demonstrated that a number of changes in the hepatic ECM in prefibrotic ALD not only are present, but may also contribute to disease progression. The purpose of this review is to summarize the established and proposed changes to the hepatic extracellular matrix (ECM) that may contribute to earlier stages of ALD development and to discuss potential mechanisms by which these changes may mediate the progression of the disease.

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Osteopontin is an important mediator of alcoholic liver diseaseviahepatic stellate cell activation

Abstract: OPN is a key mediator of the alcohol-induced effects on hepatic stellate cell functions and liver fibrogenesis.

Cited by 46 publications

References 45 publications

Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis

Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis

Targeting inflammation for the treatment of alcoholic liver disease

Transitional Remodeling of the Hepatic Extracellular Matrix in Alcohol-Induced Liver Injury

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