Osteopontin Promoter Polymorphisms are Associated With Susceptibility to Gastric Cancer

Lee, Teng‐Yu; Lin, Jaw‐Town; Wu, Chien-Hung; Yu, Cheng-Chan; Wu, Ming–Shiang; Lee, Tso-Ching; Chen, Hsiao-Ping; Wu, Chunying

doi:10.1097/mcg.0b013e31827b9325

Cited by 17 publications

(14 citation statements)

References 35 publications

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“…OPN promoter polymorphisms are associated with susceptibility to gastric cancer. The combination of SNP −443 (T/C or C/C) and −616 (T/T or T/G) significantly increases susceptibility to gastric cancer (Lee et al, 2013). …”

Section: Opn In Clinical Evaluationsmentioning

confidence: 99%

Role of osteopontin in the pathophysiology of cancer

2014

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Osteopontin (OPN) is a multifunctional cytokine that impacts cell proliferation, survival, drug resistance, invasion, and stem like behavior. Due to its critical involvement in regulating cellular functions, its aberrant expression and/or splicing is functionally responsible for undesirable alterations in disease pathologies, specifically cancer. It is implicated in promoting invasive and metastatic progression of many carcinomas. Due to its autocrine and paracrine activities OPN has been shown to be a crucial mediator of cellular cross talk and an influential factor in the tumor microenvironment. OPN has been implicated as a prognostic and diagnostic marker for several cancer types. It has also been explored as a possible target for treatment. In this article we hope to provide a broad perspective on the importance of OPN in the pathophysiology of cancer.

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Section: Opn In Clinical Evaluationsmentioning

confidence: 99%

Role of osteopontin in the pathophysiology of cancer

2014

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“…An additional 4 articles, without control group data, were excluded. Thus, a total of 10 articles with 2,391 cases and 3,007 controls were included in the meta-analysis 20 21 22 23 24 25 26 27 28 29 . For the rs17524488 ( −156 GG/G ) polymorphism, 7 studies were available, including a total of 2,130 cases and 2,644 controls.…”

Section: Resultsmentioning

confidence: 99%

“…However, individual studies have yielded inconsistent or conflicting findings, possibly caused by limitations associated with an individual study. To shed light on these contradictory results and to more precisely evaluate the relationship among OPN gene polymorphisms and cancer risk, we performed a meta-analysis of 10 published studies 20 21 22 23 24 25 26 27 28 29 , the original regions of which were all from China, no other ethnicities or regions existed.…”

mentioning

confidence: 99%

OPN gene polymorphisms, rs17524488 GG/G, rs11730582 T/C and rs9138 C/A and cancer risk in a Chinese population

Dai

Zhu

et al. 2015

Sci Rep

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Previous studies have investigated the association between osteopontin (OPN) gene polymorphisms, rs17524488 (−156 GG/G), rs11730582 (−443 T/C), and rs9138 (C/A) and cancer risk in the Chinese population. However, the results are controversial and indefinite. We therefore carried out a meta-analysis to derive a more precise estimation of these associations. The PubMed database was systematically searched to identify potentially eligible reports. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations between 3 OPN gene polymorphisms and cancer risk in a Chinese population. A total of 10 articles involving 2,391 cases and 3,007 controls were evaluated. The pooled OR indicated that OPN rs17524488 (−156 GG/G) polymorphism was significantly associated with cancer risk in Chinese population. In a stratified analysis by source of control, significant associations were also observed among rs17524488 (−156 GG/G) and rs11730582 (−443 T/C) polymorphisms and cancer. In addition, a stronger association was observed between rs9138 (C/A) polymorphism and cancer risk. In conclusion, this meta-analysis suggests that OPN rs17524488 (−156 GG/G), rs11730582 (−443 T/C), and rs9138 (C/A) polymorphisms may be associated with cancer susceptibility in the Chinese population. Nevertheless, further investigation on a larger population covering different ethnicities are warranted.

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“…In the pathological conditions of gastric cancer, overexpression of OPN has been repeatedly demonstrated to promote gastric cancer invasion and metastasis [33][34][35]. Moreover, genetic polymorphisms in the OPN promoter (-443C and -616T) were shown to increase gastric cancer susceptibility, suggesting a role for OPN in gastric cancer initiation [36]. We have previously shown that H. pylori can increase sOPN secretion from macrophages [12].…”

Section: Discussionmentioning

confidence: 97%

Intracellular Osteopontin Induced by CagA‐positive Helicobacter pylori Promotes Beta‐catenin Accumulation and Interleukin‐8 Secretion in Gastric Epithelial cells

Chang

Yang²,

Cheng

et al. 2015

Helicobacter

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Osteopontin Promoter Polymorphisms are Associated With Susceptibility to Gastric Cancer

Abstract: Our results suggest that polymorphisms in the OPN promoter are associated with the development of gastric cancer, and the combination of SNP -443 (T/C or C/C) and -616 (T/T or T/G) most significantly increases susceptibility to gastric cancer.

Cited by 17 publications

References 35 publications

Role of osteopontin in the pathophysiology of cancer

Role of osteopontin in the pathophysiology of cancer

OPN gene polymorphisms, rs17524488 GG/G, rs11730582 T/C and rs9138 C/A and cancer risk in a Chinese population

Intracellular Osteopontin Induced by CagA‐positive Helicobacter pylori Promotes Beta‐catenin Accumulation and Interleukin‐8 Secretion in Gastric Epithelial cells

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