Osteoporosis

Kaplan, Frederick S.

doi:10.1300/j013v10n02_09

Cited by 5 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The unfavorable outcome of this process is the development of such chronic degenerative conditions as osteoporosis and osteoarthritis. Osteoporosis is the most common skeletal disorder in the world, and is second only to osteoarthritis as the leading cause of musculoskeletal morbidity in the elderly (Kaplan, 1985;Lawrence et al, 1998). The main factor in osteoarthritis development is underlying genetic predisposition, whereas age is a dominant determinant of its manifestation .…”

mentioning

confidence: 99%

Association between physique characteristics and hand skeletal aging status

Kalichman

Malkin

Kobyliansky

2005

American J Phys Anthropol

View full text Add to dashboard Cite

The aim of the present study was to evaluate the association between skeletal aging traits (obtained from evaluation of hand radiographs) and physique characteristics, including indices of obesity, skeletal size, muscular development, and the somatotypes of Heath and Carter (1967) and of Deriabin (1985). To achieve our aims, we used multiple regression analysis, and Pearson's and canonical correlation analyses. The studied population comprised 629 males and 561 females aged 18-90 years, all members of the Chuvasha (Russian Federation). The present study provides evidence for a connection between hand bone aging traits and physique characteristics. The cortical index showed a small but significant correlation with adiposity and the index of overall physique, but bone mineral density (BMD) traits were not correlated with the index of overall physique. Deriabin's set of somatotypes was significantly correlated with BMD, but could explain only 2% of its variation. Significant correlations of the hand osteoarthritis trait were observed with indices of adiposity. Also observed were statistically significant canonical correlations with both sets of somatotypes, which enabled us to predict 2-3% of hand osteoarthritis variation by a combination of somatotype components. Osseometric score evinced statistically significant correlations with most indices of physique as well as with a combination of somatotype components. These findings may prove helpful in epidemiological studies, because they show that body composition is the factor that is statistically significantly associated with skeletal aging.

show abstract

mentioning

confidence: 99%

Association between physique characteristics and hand skeletal aging status

Kalichman

Malkin

Kobyliansky

2005

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

“…Osteoporosis, which is characterized by decreased bone mineral content, is now the most prevalent bone disease . It is the leading cause of musculoskeletal disability in the elderly, and its complications often result in a mortality rate of 15% or more [Kaplan, 1983]. Clinically, many treatments such as a regimen of calcium, vitamin D supplements, and hormones are effective in treating osteoporosis but have some adverse side effects, for example, hypercalcemia, hypercalcuria, and breast cancer, which vary in severity [Paterson, 1980;Mahavni and Sood, 2001].…”

Section: Introductionmentioning

confidence: 99%

The effects of long‐term exposure to extremely low‐frequency magnetic fields on bone formation in ovariectomized rats

Çelik

Gür

Akdag

et al. 2012

Bioelectromagnetics

View full text Add to dashboard Cite

The effects of long-term extremely low-frequency magnetic field (ELF-MF) exposure on bone formation and biochemical markers were investigated in ovariectomized rats. Sixty mature female Sprague-Dawley rats were randomly divided into four different groups (n = 15): (i) unexposed control (CTL); (ii) ovariectomized only (OVX); (iii) non-ovariectomized, exposed (SHAM + ELF-MF); and (iv) ovariectomized, exposed (OVX + ELF-MF). The third and fourth groups were exposed to 1.5 mT ELF-MF for 4 h a day for 6 months. Bone mineral density (BMD) was determined using dual energy X-ray absorption (DEXA) measurements. The formation and resorption of bone were evaluated using bone-specific alkaline phosphatase (BAP), osteocalcin, osteoprotogerin, and N-telopeptide. After 6 months of ELF-MF therapy, BMD values were significantly lower in the OVX group and higher in the OVX + ELF-MF and SHAM + ELF-MF groups than they were before therapy (P < 0.001). Although there was no significant difference in BMD values among the groups before therapy, the BMD values increased significantly after 6 months in the OVX + ELF-MF and SHAM + ELF-MF groups and were reduced in the OVX group compared to the CTL group (P < 0.001). The concentrations of BAP, osteocalcin, osteoprotogerin, and N-telopeptide in the three experimental groups also changed in a significant way compared to the CTL group. The results of the present study suggest that osteoporosis can be inhibited by ELF-MF stimulation treatments. It was also concluded that ELF-MF may be useful in the prevention of osteoporosis in ovariectomized rats.

show abstract

“…The pathological alterations are often viewed as comprising a chronic degenerative disease (Crews and Gerber, 1994;Plato et al, 1994), referred to as osteoarthritis (OA) and osteoporosis (OP). OP is the most common skeletal disorder in the world and is second only to OA as the leading cause of musculoskeletal morbidity in the elderly (Kaplan, 1985, Lawrence et al, 1998.…”

mentioning

confidence: 99%

Interrelationship between bone aging traits and basic anthropometric characteristics

Kalichman

Kobyliansky

Livshits

2002

American J Hum Biol

View full text Add to dashboard Cite

Using plain hand radiographs, the age dependence of various bone-aging traits (bone mineral density [BMD], cortical index [CI], osteoarthritis [OA], and osseographic [OSS] scores) was evaluated to test whether the correlation among these traits is an individual- or population-based phenomenon. In addition, the effect of anthropometric features on variation of bone-aging traits was estimated. The study included 1,295 individuals from Chuvasha, Russia, 18 to 89 years. BMD was measured from the compact compartment of the middle and distal phalanges of both 3(rd) fingers. The CI of the II-IV metacarpal bones and II-IV proximal phalanges was obtained. The development of OA was based on the standard Kellgren and Lawrence grading scheme for 28 hand joints. OSS score, a surrogate measure that takes into account different kinds of bone changes, was also obtained for each individual. Body weight and height, eight skinfold thicknesses on the trunk and extremities, and breadths of the long bones were measured. Sex-based univariate analyses and multivariate statistical analysis showed the following: 1) Age dependence was defined more strongly in "OA-linked" compared to "osteoporosis (OP)-linked" traits; 2) While "OP-linked" bone-aging traits correlated with age differently between sexes, "OA-linked" traits did not; 3) The strong interrelationship between OA-linked and OP-linked traits in both sexes became very weak and statistically insignificant (P > 0.10) after adjustment for age. Thus, OA and OP conditions in the same individual develop independently and probably reflect different underlying physiological mechanisms. 4) Anthropometric characteristics were significantly correlated with bone-aging traits, but correlations were low (r < 0.20). Thus, the contribution of anthropometric characteristics to the rate and pattern of bone aging of the hand was to relatively small.

show abstract

Osteoporosis

Cited by 5 publications

References 12 publications

Association between physique characteristics and hand skeletal aging status

Association between physique characteristics and hand skeletal aging status

The effects of long‐term exposure to extremely low‐frequency magnetic fields on bone formation in ovariectomized rats

Interrelationship between bone aging traits and basic anthropometric characteristics

Contact Info

Product

Resources

About