Osteoporosis in men: a potential role for the sex hormone binding globulin

Legrand, Érick; Hedde, C; Gallois, Yves; Degasne, I.; Casson, F; Mathieu, E; Basle, Michel‐Félix; Chappard, Daniel; Audran, Maurice

doi:10.1016/s8756-3282(01)00478-1

Cited by 115 publications

(72 citation statements)

References 18 publications

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“…In men, the effect of SHBG on incident non-vertebral fractures has not been studied in prospective data. Most authors suggest that higher SHBG increases the risk of fractures by binding estradiol and decreasing its bioavailability (15,20,21). The independent effect of SHBG on risk of fractures adjusted for total estradiol in the present study is against this explanation.…”

Section: Discussioncontrasting

confidence: 51%

“…Circulating estradiol is reported as being associated with prevalent vertebral fractures in women (16), in men but not women (19), whereas others reported no such association in men (17,21). These (15,18) and in men (24), but the effect was dependent on weight in one study (18).…”

Section: Discussionmentioning

confidence: 86%

“…In women, higher SHBG is reported to be associated with increased risk of incident vertebral, hip, and a combination of vertebral and nonvertebral fractures in prospective studies (15,18,20,22). In men, SHBG is associated with prevalent vertebral fractures and the combination of vertebral and non-vertebral fractures as the endpoint (17,21). In men, the effect of SHBG on incident non-vertebral fractures has not been studied in prospective data.…”

Section: Discussionmentioning

confidence: 99%

“…Some investigators have reported lower sex steroids and higher sex hormone-binding globulin (SHBG) associated with bone loss (5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and increased fracture risk but this is not consistently reported (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), perhaps because many factors influence fracture risk, particularly falls (26,27). However, few prospective data are available examining the contribution of sex steroids and SHBG on fracture risk (15,18,20,22,24).…”

Section: Introductionmentioning

confidence: 99%

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A prospective study of sex steroids, sex hormone-binding globulin, and non-vertebral fractures in women and men: the Tromsø Study

Bjørnerem¹,

Ahmed²,

Joakimsen³

et al. 2007

eur j endocrinol

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Objectives: As bone fragility is partly the result of sex hormone deficiency, we sought to determine whether circulating sex steroids or sex hormone-binding globulin (SHBG) predicts non-vertebral fractures. Methods: Forearm bone mineral density (BMD), total estradiol and testosterone, calculated free levels, and SHBG were measured in 1386 postmenopausal women and 1364 men aged 50-84 years at baseline in the Tromsø Study (1994)(1995). Non-vertebral fractures were documented between 1994 and 2005. Results: During 8.4 years (range 0.01-10.4) of follow-up, 281 women and 105 men suffered non-vertebral fractures. For both sexes, fracture cases had lower BMD and higher SHBG, but sex steroids were not lower. Each standard deviation (S.D.) increase in SHBG increased non-vertebral fracture risk in women (hazards ratio (HR) 1.17; 95% confidence interval (CI) 1.03-1.33) and men (HR 1.26; 95% CI 1.03-1.54). After further adjustment for BMD, the risk was not statistically significant in women (HR 1.09; 95% CI 0.95-1.24) or men (HR 1.22; 95% CI 0.99-1.49). Each S.D. decrease in BMD increased fracture risk in women (HR 1.36; 95% CI 1.19-1.56) and men (HR 1.41; 95% CI 1.15-1.73). Fracture rates were highest in participants with SHBG in the highest tertile and BMD in the lowest tertile and were 37.9 and 17.0 per 1000 person-years in women and men respectively. However, in both sexes the combination of BMD and SHBG was no better predictor of fracture risk than BMD alone. Sex steroids were not associated with fracture risk. Conclusions: Measurements of sex steroids or SHBG are unlikely to assist in decision making regarding fracture risk susceptibility.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A prospective study of sex steroids, sex hormone-binding globulin, and non-vertebral fractures in women and men: the Tromsø Study

Bjørnerem¹,

Ahmed²,

Joakimsen³

et al. 2007

eur j endocrinol

View full text Add to dashboard Cite

show abstract

“…Selon l'agence française de sécu-rité sanitaire des produits de sante (AFSSAPS), en raison de la présence d'une prothèse de hanche, ce patient est classé dans la catégorie B des patients à risque chez qui la chirurgie implantaire constitue une contre-indication absolue. Par ailleurs, dans le SM, il existe une ostéopo-rose [5] et une ostéopénie [6] . Toutefois plusieurs études ont montré qu'il n'y a pas de différence significative entre l'ostéointégration des implants chez les patients sains et celle chez les patients ayant une ostéoporose.…”

Section: Les Facteurs Généraux Induits Par Le Smunclassified