Osteosarcoma metástasis cerebral

González, M.E. Mateos; López‐Laso, Eduardo; Colino, Carmen Garrido; Valdivieso, Manuel; Pérez, Javier Bajo; Heras, Rogelio Simón de las

doi:10.1016/s1695-4033(02)77846-6

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…4 Two of these cases of osteoblastic osteosarcoma were presented with brain metastasis simultaneously with or after lung involvement, for which they suggested periodic screening with disease recurrence. 24 Similar case reports were observed where fibroblastic osteosarcoma presented with brain metastasis after 15 months of pneumonectomy for lung metastasis 25 and pulmonary, isolated central nervous system relapse can occur in patients with fibroblastic osteosarcoma. 26,27 Osteosarcoma can present with hemorrhagic cerebellar metastasis, where the patient presented with acute neurologic deterioration 28 and multifocal osteosarcomas of the skull presenting with intracranial hemorrhage.…”

Section: Discussionsupporting

confidence: 62%

Isolated Cerebral Metachronous Metastasis in Fibular Osteosarcoma: A Rare Case Report with Review of Literature

Nayak,

Rastogi,

Sebastian

et al. 2023

Indian J Med Paediatr Oncol

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Isolated brain involvement is rarely reported as isolated metachronous metastasis from osteosarcoma. Herein, we report a case of fibular osteosarcoma in a young female who presented with solitary hemorrhagic metachronous cerebral metastasis after years of disease-free interval. Imaging showed a large mass lesion in the right posterior temporal lobe with internal areas of bleed not associated with calcification or ossification mimicking high-grade glioma. No other sites of distant metastases were found on the workup. Two-dimensional echocardiography was done to rule out any cardiac anomaly, including the shunt defect, but no abnormality was detected. She was operated for the cerebral lesion, and histopathology of the resected specimen showed osteosarcoma. The patient was started on chemotherapy and is doing well so far. This case presents a unique scenario of osteosarcoma with an isolated lesion in the brain without any other site of distant metastasis.

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Section: Discussionsupporting

confidence: 62%

Isolated Cerebral Metachronous Metastasis in Fibular Osteosarcoma: A Rare Case Report with Review of Literature

Nayak,

Rastogi,

Sebastian

et al. 2023

Indian J Med Paediatr Oncol

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Central nervous system metastasis from osteosarcoma: Case report and literature review

Nieto-Coronel

López-Vásquez

Marroquín-Flores

et al. 2018

Reports of Practical Oncology & Radiotherapy

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Osteosarcoma is the most common primary malignancy of bone in children and young adults, the highest incidence peak is during adolescence and doesn't have any gender predominance. The main site of metastasis are the lungs and extrapulmonary cases are occasional. The incidence of metastasis in the Central Nervous System (CNS) is 2-6.5%, increase to 10-15% in patients with pulmonary metastases. Therefore, metastatic disease of the CNS is rare and the information on such patients is limited. Here, we describe a case of a 20-year old patient diagnosed with osteosarcoma in the left distal femur stage IIB, he developed pulmonary disease, during palliative chemotherapy experienced relapse to the brain classified as (RPA) class II, and was treated with external radiotherapy (30 Gy in 10 fractions) and later he had a poor evolution and died.

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Osteosarcoma metástasis cerebral

Cited by 2 publications

References 20 publications

Isolated Cerebral Metachronous Metastasis in Fibular Osteosarcoma: A Rare Case Report with Review of Literature

Isolated Cerebral Metachronous Metastasis in Fibular Osteosarcoma: A Rare Case Report with Review of Literature

Central nervous system metastasis from osteosarcoma: Case report and literature review

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