Osteosarcoma (osteogenic sarcoma) of the jaws presenting in general dental practice - a series of  four cases

Costello, Liam; Toner, Mary; Pierse, Dermot; Stassen, Leo F A

doi:10.1038/s41415-021-2943-x

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…It is important to note that this type of neoplasm presents two major difficulties. First, there is the increased incidence among adolescents, and subsequently, there is the high degree of metastasis, especially at the lung level, and the reduction in the survival rate [29]. Oropharyngeal squamous cell carcinoma is commonly referred to as throat cancer.…”

Section: Discussionmentioning

confidence: 99%

Eugenol: In Vitro and In Ovo Assessment to Explore Cytotoxic Effects on Osteosarcoma and Oropharyngeal Cancer Cells

Racea,

Macasoi,

Dinu

et al. 2023

Plants

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Cancer is a significant health problem worldwide; consequently, new therapeutic alternatives are being investigated, including those found in the vegetable kingdom. Eugenol (Eug) has attracted attention for its therapeutic properties, especially in stomatology. The purpose of this study was to investigate the cytotoxicity of Eug, in vitro, on osteosarcoma (SAOS-2) and oropharyngeal squamous cancer (Detroit-562) cells, as well as its potential irritant effect in ovo at the level of the chorioallantoic membrane (CAM). The data obtained following a 72 h Eug treatment highlighted the reduction in cell viability up to 41% in SAOS-2 cells and up to 37% in Detroit-562 cells, respectively. The apoptotic-like effect of Eug was indicated by the changes in cell morphology and nuclear aspect; the increase in caspase-3/7, -8 and -9 activity; the elevated expression of Bax and Bad genes; and the increase in luminescence signal (indicating phosphatidylserine externalization) that preceded the increase in fluorescence signal (indicating the compromise of membrane integrity). Regarding the vascular effects, slight signs of coagulation and vascular lysis were observed, with an irritation score of 1.69 for Eug 1 mM. Based on these results, the efficiency of Eug in cancer treatment is yet to be clarified.

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Section: Discussionmentioning

confidence: 99%

Eugenol: In Vitro and In Ovo Assessment to Explore Cytotoxic Effects on Osteosarcoma and Oropharyngeal Cancer Cells

Racea,

Macasoi,

Dinu

et al. 2023

Plants

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“…The prognosis of OSJ is better than that of OS affecting extremities, with better survival data and fewer distant metastases [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Pathological Features of Osteosarcomas of the Jaws: A Retrospective Study

Rodriguez-Molinero,

Pozo-Kreilinger,

Ruiz-Roca

et al. 2024

Clinics and Practice

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Introduction: Osteosarcomas of the jaw (OSJs) are rare tumors with distinct characteristics from osteosarcomas affecting other bones. This study aims to analyze the clinical, pathological, and therapeutic characteristics of OSJs. Methods: A retrospective, descriptive cross-sectional study including patients diagnosed with OSJ registered at the “La Paz” University Hospital, Madrid, was performed. Results: Data of eight patients with a diagnosis of OSJ were obtained during the study period of 22 years (2002–2024). The mean age of the patients was 41 years. The distribution was 1:1 between the maxilla and mandible. Painful inflammation was the most frequent clinical manifestation. Conventional osteoblastic osteosarcoma was the most predominant histological type. Survival rate at 5 years was 50%, which decreased to 25% at 10 years. Conclusions: OSJs differ from conventional osteosarcomas of long tubular bones. Surgery continues to be the mainstay of treatment. However, more studies are needed through which more standardized protocols can be proposed for adjuvant therapeutic management.

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“…The prognosis of OSJ is better than that of OS of the extremities, with better survival data and fewer distant metastases [16,17].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Pathological Features of Osteosarcomas of the Jaws. A Retrospective Study

Rodríguez-Molinero¹,

Pozo‐Kreilinger²,

Ruiz‐Roca³

et al. 2023

Preprint

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Introduction: Osteosarcomas of the jaw (OSJ) are rare tumors with a different behavior from osteosarcomas of other bones. This study aims to analyze the clinical, pathological, and therapeutic characteristics of this type of sarcoma. Methods: a retrospective observational study of cases diagnosed with OSJ registered at the “La Paz” University Hospital (Madrid). Results: Eight cases with a diagnosis of OSJ were obtained in a study period of 22 years (2000-2022). The mean age was 41 years. The distribution was 1:1 between the maxilla and mandible. Painful inflammation was the most frequent clinical manifestation. Conventional osteoblastic osteosarcoma was the most common. Survival at 5 years was 50%, while at 10 years, it decreased to 25%. Conclusions: OSJ differs from conventional osteosarcomas of long tubular bones. Surgery continues to be the mainstay of treatment; more studies are needed in which more standardized protocols can be proposed for adjuvant therapeutic management.

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Osteosarcoma (osteogenic sarcoma) of the jaws presenting in general dental practice - a series of four cases

Cited by 3 publications

References 30 publications

Eugenol: In Vitro and In Ovo Assessment to Explore Cytotoxic Effects on Osteosarcoma and Oropharyngeal Cancer Cells

Eugenol: In Vitro and In Ovo Assessment to Explore Cytotoxic Effects on Osteosarcoma and Oropharyngeal Cancer Cells

Clinical and Pathological Features of Osteosarcomas of the Jaws: A Retrospective Study

Clinical and Pathological Features of Osteosarcomas of the Jaws. A Retrospective Study

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