“…Current research suggested that the theoretical basis for the rapid postoperative orthodontic tooth movement was the phenomenon of regional acceleratory phenomenon (RAP) (Amit et al, 2012; Mueller et al, 1991; Verna, 2016). Specifically, the orthognathic surgery‐mediated regional alveolar bone undergoing demineralization and remineralization, and triggered an active period of osteoclasts for 3–4 months (Li et al, 2018; Nowak & Trybek, 2016). However, there was still a lack of systematic research to illustrate the molecular mechanisms involved in osteoclastic activity induced by surgical trauma.…”