Osthole enhances the immunosuppressive effects of bone marrow‐derived mesenchymal stem cells by promoting the Fas/FasL system

Yu, Yang; Chen, Meng; Yang, Shiyao; Shao, Bingyi; Chen, Liang; Dou, Liping; Gao, Jing; Yang, Deqin

doi:10.1111/jcmm.16459

Cited by 23 publications

(12 citation statements)

References 43 publications

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“…One hypothesis suggestes that the upregulation of protein and mRNA expression level of autophagy-associated genes, Beclin1, and LC3 may be the cause [107]. Yang et al found osthole could restore the immunosuppressive ability of osteoporotic BMMSCs and enhance the immunosuppressive effects by promoting the Fas/FasL system [108]. Osthole can also promote bone strength and enhance fracture healing through the activation of BMP2 signaling in chondrocytes [109].…”

Section: Osteogenic Activitymentioning

confidence: 99%

Osthole: an overview of its sources, biological activities, and modification development

Sun

Zhang

2021

Med Chem Res

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Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants such as Cnidium monnieri and Angelica pubescens. It can be obtained via extraction and separation from plants or total synthesis. Plenty of experiments have suggested that osthole exhibited multiple biological activities covering antitumor, anti-inflammatory, neuroprotective, osteogenic, cardiovascular protective, antimicrobial, and antiparasitic activities. In addition, there has been some research done on the optimization and modification of osthole. This article summarizes the comprehensive information regarding the sources and modification progress of osthole. It also introduces the up-to-date biological activities of osthole, which could be of great value for its use in future research.

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Section: Osteogenic Activitymentioning

confidence: 99%

Osthole: an overview of its sources, biological activities, and modification development

Sun

Zhang

2021

Med Chem Res

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“…Recently, the immunosuppressive effect of MSCs is the hotspot for MSC treatment. Several studies have confirmed that the Fas/FasL system is important for Tcell apoptosis in inflammatory and immune diseases [ 28 – 30 ], and enhancement of Fas/FasL expression is a promising strategy to improve MSC cytotherapy at the molecular level [ 31 ]. In our study, we found that SCC could increase the expression of APO-1 at both the transcriptional level of mRNA and protein level in BM MSCs.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sodium Chlorophyllin Copper on APO-1 Expression in Bone Marrow Mesenchymal Stem Cells of Rats with Aplastic Anaemia

Jin

Dai²,

Xuan

et al. 2022

Journal of Immunology Research

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Background. Aplastic anaemia (AA) is a highly prevalent blood disorder in the East and Southeast Asian countries, and a proportion of the patients is poorly treated with immunosuppressive agents. This study is aimed at exploring the effects of sodium copper chlorophyllin (SCC) on rats with AA and at providing the theoretical basis for the treatment of AA using traditional Chinese medicine. Methods. A rat model of AA was induced by combining 5-fluorouracil with busulfan, and different groups were treated with 25 mg/kg cyclosporin A (CsA) and low-, medium-, and high-dose SCC (25-, 50-, and 100-mg/kg; L-, M-, and H-SCC, respectively). A comparative analysis of peripheral blood counts, T-cell subsets, cytokine levels, bone marrow pathology, and APO-1 expression in mesenchymal stem cells in each group was conducted. Results. SCC can increase the platelet count and haemoglobin concentration in the peripheral blood of AA rats, whereas bone marrow biopsies revealed that the number of nucleated cells and megakaryocytes of SCC-treated rats increased compared with the model group. This was particularly evident in the H-SCC group. As regards the correction of immune function, unlike CsA, which reduced the absolute CD8+ T-cell count, SCC corrected the imbalanced CD4/CD8 ratio by increasing the absolute CD4+ T-cell count, whereas SCC increased the number of regulatory T-cells and reduced the level of interferon-γ in AA rats. When comparing the expression of APO-1 in the MSCs, results of the reverse-transcriptase polymerase chain reaction and Western blot analysis showed that SCC can increase the expression of APO-1 both at the mRNA and protein levels. Conclusion. We found that SCC can improve haematopoietic function and regress immune disorders in AA rats, which enhanced the expression of APO-1 in bone marrow MSCs. This may be one of the mechanisms of SCC in treating AA.

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“…Studies have shown that knub recurrence may be hardly interrelated to the mechanism of immune escape. FasL gene is an important member of the knub necrosis family and is an important factor in the occurrence of immune escape in bladder carcinoma [ 15 ]. The taller level of NMP22 in sufferers with bladder carcinoma before surgery may indicate that the taller the conveying of FasL gene, the more prone to immune escape.…”

Section: Discussionmentioning

confidence: 99%

The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer

Huang

Ai²,

et al. 2022

Journal of Immunology Research

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Objective. To investigate the value of preoperative urinary nuclear matrix protein 22 (NMP22) and Cystatin B (CSTB) expressions in evaluating the postoperative recurrence of bladder cancer. Methods. The clinical case data of 102 patients with bladder cancer who underwent surgical treatment from January 2017 to January 2022 were collected, and the patients were divided into a recurrence group ( n = 54 ) and nonrecurrence group ( n = 48 ) according to whether the patients recurred after surgery, and the preoperative NMP22 and CSTB expression levels between the two groups were compared. Receiver operating curve (ROC) was used to analyze the evaluation value of preoperative NMP22 and CSTB expression in patients with bladder cancer postoperative recurrence. Logistic multivariate regression method was used to analyze the correlation between preoperative NMP22 and CSTB expression and postoperative bladder cancer recurrence. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of NMP22 and CSTB single detection and combined detection were evaluated for postoperative recurrence of bladder cancer. Results. The preoperative expression levels of NMP22 and CSTB in the recurrence group were significantly higher than those in the nonrecurrence group ( P < 0.05 ). The results of ROC curve analysis showed that the AUC of preoperative NMP22 and CSTB expression levels to assess postoperative recurrence of bladder cancer was 0.696 and 0.659, respectively ( P < 0.05 ). Logistic multivariate regression analysis showed that preoperative NMP22 and CSTB overexpression was an independent risk factor for postoperative recurrence of bladder cancer ( OR = 1.042 , 2.307, P < 0.05 ). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of preoperative NMP22 combined with CSTB in evaluating bladder cancer recurrence after surgery were higher than those of preoperative NMP22 and CSTB alone, and the differences were statistically significant ( P < 0.05 ). Conclusion. Preoperative NMP22 and CSTB conveying is hardly interrelated to postoperative recurrence of bladder carcinoma and has certain appraisal worth for postoperative recurrence of bladder carcinoma, and the combined testing of the two has a taller appraisal worth. NMP22 combined with CSTB detection will help to detect postoperative recurrence of bladder cancer and formulate effective treatment measures in time.

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Osthole enhances the immunosuppressive effects of bone marrow‐derived mesenchymal stem cells by promoting the Fas/FasL system

Cited by 23 publications

References 43 publications

Osthole: an overview of its sources, biological activities, and modification development

Osthole: an overview of its sources, biological activities, and modification development

Effects of Sodium Chlorophyllin Copper on APO-1 Expression in Bone Marrow Mesenchymal Stem Cells of Rats with Aplastic Anaemia

The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer

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