Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations

Han, Sang Yeob; Lee, Jong Rok; Kwon, Young Kyu; Jo, Mi Jeong; Park, Sook Jahr; Kim, Sang Chan; Lee, Hyeung Sik; Ku, Sae Kwang

doi:10.1016/j.jep.2007.08.019

Cited by 19 publications

(27 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, calcium supplements are used for aiding treatment of osteoporosis and fracture prevention (Nordin, 1997). Han et al (2007) worked on Ostreae testa shell powder that contain inorganic calcium and proved that this powder prevents bone loss in OVX mice. The present work recorded that one of the main constituent of CES powder is calcium where it contains about 19.38% of inorganic calcium.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Sayed¹,

Soliman²,

Fahmy³

et al. 2013

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

The efficacy of Coelatura aegyptiaca shell powder (CES, 500 mg/kg BW) was evaluated as a calcium supplement in ovariectomized (OVX) rats for ten weeks of treatment. The biochemical components and the antioxidant properties of the shell powder were determined. The bone mineral density (BMD), bone mineral content (BMC), calcium (Ca) and phosphorus (P) contents in serum and bone, serum total alkaline phosphatase (TALP) and bone alkaline phosphatase (BALP), serum calcitonin and parathyroid (PTH) hormones were determined. Furthermore, some of the oxidative stress markers [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant capacity (TAC)] were estimated in bone. The current study revealed that CES contained 19.38% Ca, 0.315% P as well as some of antioxidant amino acids which have a potent antioxidant activity against 1,1-diphenylpicrylhydrazyl (DPPH) free radical. Administration of CES to OVX rats increased BMD, BMC, tibial Ca and P contents and BALP activity, as compared to OVX rats. An ameliorative effect was recorded in the levels of calcitonin, PTH, MDA, SOD, GPx and TAC subsequent to CES administration to OVX rats.This ameliorative effect of CES powder against osteoporosis may be attributed to its antioxidant efficacy and/or to its Ca content. In conclusion, CES may have the potential to develop a clinically useful anti-osteoporotic agent, since its effect was comparable with alendronate (6.5 mg/kg BW/week).

show abstract

Section: Discussionmentioning

confidence: 99%

“…Freshwater mussel C. aegyptiaca was collected from the Nile River at Giza governorate, Egypt. The meat was removed and the CES was prepared according to Han et al (2007). The prepared CES powder was stored in a desiccator to protect it from light and moisture until used.…”

Section: Preparation Of C Aegyptiaca Shells (Ces) Powdermentioning

confidence: 99%

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Sayed¹,

Soliman²,

Fahmy³

et al. 2013

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Co., Hwasung, Korea) in a mixture of 70% N 2 O and 28.5% O 2 . The surgical protocol was performed according to established methods (35,37,38). The OVX treatment group (n=8) underwent open surgery involving bilateral OVX via a midline incision of linea alba.…”

Section: Animals and Husbandrymentioning

confidence: 99%

“…Cortical bone thickness was also measured in the mid-shaft regions of the femur. Trabecular bone volume (TV/BV, TBV; %), thickness of trabecular bone (Tbt; µm/trabecular bone), number (Tbn; mean numbers of trabecular bone/epiphyseal regions), length (Tbl; mm/trabecular bone), and cortical bone thickness (Cbt; µm/mid-shaft cortical bone) were measured for bone mass and structure, and osteoclast cell number (Ocn; mean osteoclast cell numbers/ epiphyseal regions) and ratio (OS/BS; %) were measured for bone resorption, as described previously (37,38,46).…”

Section: Animals and Husbandrymentioning

confidence: 99%

“…OVX-treated ddY mice have also been used to investigate the mechanisms underlying menopause-related complications in humans as these complications share various similarities with postmenopausal climacterium symptoms (32)(33)(34). This rodent model exhibits symptoms that resemble those of women with postmenopausal climacterium symptoms, including cardiovascular diseases, obesity, hyperlipidemia, osteoporosis, organ steatosis and mental disorders (35)(36)(37)(38). In the present study, anti-climacteric effects were evaluated and separated into five categories: i) estrogenic effects; ii) anti-obese effects; iii) hypolipidemic effects; iv) hepatoprotective effects against liver steatosis; and v) anti-osteoporotic effects.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice

Kang¹,

Choi²,

Kim³

et al. 2017

Experimental and Therapeutic Medicine

Self Cite

View full text Add to dashboard Cite

Abstract. In the present study, the complex anti-climacterium potential of standardized pomegranate concentrated solution (PCS) was investigated using bilateral ovariectomy (OVX) female ddY mice. Changes in body weight and gain during experimental periods, food consumption, serum estradiol levels, total body and abdominal fat densities, abdominal fat pads, and uterus weights were observed, along with the histopathology of abdominal fat pads and uterus for anti-obesity and estrogenic effects. In addition, liver weights, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and histopathological inspections were performed to explore the hepato-protective effects. Serum total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein, and triglyceride (TG) levels were monitored for hypolipidemic effects with total body and femur mean bone mineral density (BMD), right femur wet, dry and ash weights, strength, serum osteocalcin, bone-specific alkaline phosphatase (bALP) contents, and histological and histomorphometrical analyses for anti-osteoporosis activity. As a result of OVX, notable increases in body weight and gains, food consumption, abdominal fat mass densities, weights of abdominal fat pads deposited in the abdominal cavity, and serum AST, ALT, TC, LDL, TG, and osteocalcin levels were observed, along with decreases in the uterus, liver, and femur weights, mean total body and femur BMD, femur strength, serum bALP, and estradiol levels. In addition, marked hypertrophic alterations in adipocytes located in the deposited abdominal fat pads, liver steatosis, uterine disused atrophic changes, and decreases in bone mass and structures of the femur were also observed in OVX control mice with significant increases in bone resorption markers based on histopathological and histomorphometrical analysis. However, these estrogen-deficient climacterium symptoms were significantly (P<0.05 or P<0.01) inhibited after 84 days of continuous treatment with estradiol and PCS (1, 2 and 4 ml/kg), respectively. The present results suggested that PCS was able to effectively inhibit or refine the climacterium symptoms, including obesity, hyperlipidemia, hepatic steatosis, and osteoporosis, induced by OVX in ddY mice.

show abstract

Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition

et al. 2015

View full text Add to dashboard Cite

Oysters (Oys) contain various beneficial components, such as, antioxidants and amino acids. However, the effects of Oys or taurine (Tau), a major amino acid in Oys on bone growth have not been determined. In the present study, we evaluated the effects of Oys or Tau on linear bone growth in a mouse model of protein malnutrition. To make the protein malnutrition in a mouse, we used a low protein diet. Growth plate thickness was increased by Oys or Tau. Bone volume/tissue volume, trabecular thickness, trabecular number, connection density, and total porosity were also improved by Oys or Tau. Oys or Tau increased insulin-like growth factor-1 (IGF-1) levels in serum, liver, and tibia-growth plate. Phosphorylations of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were increased by Oys and by Tau. These findings show that Oys or Tau may increase growth plate thickness by elevating IGF-1 levels and by promoting the phosphorylations of JAK2-STAT5, and suggest that Oys or Tau are growth-promoting substances of potential use in the food and pharmaceutical industries.

show abstract

Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations

Cited by 19 publications

References 25 publications

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice

Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition

Contact Info

Product

Resources

About