Medicinal Chemistry of Anticancer Drugs 2015
DOI: 10.1016/b978-0-444-62649-3.00011-9
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Other Nonbiological Approaches to Targeted Cancer Chemotherapy

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Cited by 3 publications
(5 citation statements)
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References 254 publications
(143 reference statements)
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“…The results revealed that 5 displayed almost cytotoxicity via apoptotic mode while 3 by weak necrotic and apoptotic mode. Apoptosis is a programmed cell death induced by several factors which interestingly, are the same that induce the expression and accumulation of Hsp90 ( Avendaño and Menendez, 2015 ). Hsp90 is an evolutionary conserved molecular chaperone that is crucial in the maintenance and folding of an array of proteins called clients.…”
Section: Discussionmentioning
confidence: 99%
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“…The results revealed that 5 displayed almost cytotoxicity via apoptotic mode while 3 by weak necrotic and apoptotic mode. Apoptosis is a programmed cell death induced by several factors which interestingly, are the same that induce the expression and accumulation of Hsp90 ( Avendaño and Menendez, 2015 ). Hsp90 is an evolutionary conserved molecular chaperone that is crucial in the maintenance and folding of an array of proteins called clients.…”
Section: Discussionmentioning
confidence: 99%
“…Hsp90 is an evolutionary conserved molecular chaperone that is crucial in the maintenance and folding of an array of proteins called clients. Some of the Hsp90 clients are oncogenic proteins and are involved in cancer cell hallmarks as cell cycle, cell survival, angiogenesis, metastasis, and apoptosis ( Avendaño and Menendez, 2015 ; Mori et al, 2015 ). Hsp90 flexible monomer consists of three domains: The N-terminal domain, the middle domain, and C-terminal.…”
Section: Discussionmentioning
confidence: 99%
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“…A combination of genetic and epigenetic alterations determines the oncogenic potential of a cell through the operation of cellular networks. PPIs have crucial roles in network connectivity maintaining cancer cells growth, transmitting oncogenic signals and gaining hallmark features of cancer 23,24 . For example, downstream phosphorelay signal transduction systems were rewired by altered PPIs (such as enhanced 14-3-3 interactions with Bad, FOXO3a, and PRAS40) as a result of Akt-activating mutations 23 .…”
Section: Discussionmentioning
confidence: 99%
“…The pivotal work of Whitesell and Neckers demonstrated that 38 inhibited the formation of a v-Src-HSP90 complex through binding to the ATP-binding site in the N-terminal domain of HSP90 [219,220]. Geldanamycin (38), the inaugural HSP90 inhibitor to undergo clinical trials, was unable to progress further clinical development due to its marked hepatotoxicity, likely linked to the electrophilic methoxybenzoquinone group [221]. As observed in prostate cancer PC-3 and LNCaP cells, the interaction of 38 with the N-terminal ATP binding domain of HSP90 induces destabilization and degradation of numerous HSP90 client proteins by the ubiquitin-proteasome pathway, among them HIF-1α [222,223].…”
Section: Polyketidesmentioning
confidence: 99%