Otolin-1, as a Potential Marker for Inner Ear Trauma after Mastoidectomy

Doğan, Murat; Şahin, Mustafa; Kurtulmus, Yusuf

doi:10.5152/iao.2019.5155

Cited by 14 publications

(15 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, that study included only 14 patients with BPPV and 10 healthy controls, and some of the patients were not having an acute episode of vertigo; this may limit the valid generalization of their results. Recently, another clinical study reported that serum otolin-1 levels significantly increased in patients who underwent mastoidectomy due to chronic otitis media and were independently associated with the duration of drilling (33).…”

Section: Discussionmentioning

confidence: 99%

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Wu¹,

Wei²,

Lu³

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

Objective: Otolin-1, a main specific otoconia matrix protein, passes through the labyrinth-blood barrier and is detectable in peripheral blood. Serum otolin-1 levels differ between patients with benign paroxysmal positional vertigo (BPPV) and healthy controls and are significantly age-related, increasing in healthy controls with age, suggesting that serum otolin-1 levels reflect otolith status. The aim of this study was to determine whether otolin-1 levels change during vertigo episodes in patients with BPPV and whether any change is specific and sensitive enough for BPPV episodes. Method: Patients diagnosed with de novo idiopathic BPPV during an acute episode were included in the study from May 2017 to May 2018. Blood samples were drawn before patients were treated with canalith-repositioning maneuvers. Serum otolin-1 levels were compared between 78 patients and 121 age-and sex-matched healthy individuals. Results: There were no significant differences between the groups in the age distribution, sex ratio, body mass index, clinical history, routine blood parameters, or total protein, albumin, uric acid, creatinine, blood urea nitrogen and lipid profiles (P > 0.05). Serum levels of otolin-1 were significantly higher in BPPV patients than in healthy controls (P < 0.001). Receiver operating characteristic analysis revealed that a serum otolin-1 value of 299.45 pg/ml was the optimal cutoff value to discriminate patients with BPPV from healthy controls (area under the curve 0.757, 95% CI 0.687∼0.826) with a sensitivity of 67.9% and a specificity of 72.7%. Conclusion: Serum levels of otolin-1 may be a potential biomarker for BPPV episodes.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Wu¹,

Wei²,

Lu³

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Hence its presence in many areas of the inner ear, including the supporting cells of the organ of Corti, striae vascularis, and semicircular canals [20]. Significantly increased levels have been found in inner ear trauma cases in mastoidectomies with a positive correlation with drilling time, confirming its role [21]. Additionally, Sacks and Parham found a strong correlation between otolin-1 levels, benign paroxysmal positional vertigo (BPPV), and osteoporosis [22].…”

Section: Molecular Biomarkers [Tablesmentioning

confidence: 87%

Biomarkers for Inner Ear Disorders: Scoping Review on the Role of Biomarkers in Hearing and Balance Disorders

et al. 2020

View full text Add to dashboard Cite

The diagnostics of inner ear diseases are primarily functional, but there is a growing interest in inner ear biomarkers. The present scoping review aimed to elucidate gaps in the literature regarding the definition, classification system, and an overview of the potential uses of inner ear biomarkers. Relevant biomarkers were categorized, and their possible benefits were evaluated. The databases OVID Medline, EMBASE, EBSCO COINAHL, CA PLUS, WOS BIOSIS, WOS Core Collection, Proquest Dissertations, Theses Global, PROSPERO, Cochrane Library, and BASE were searched using the keywords “biomarker” and “inner ear”. Of the initially identified 1502 studies, 34 met the inclusion criteria. The identified biomarkers were classified into diagnostic, prognostic, therapeutic, and pathognomonic; many were detected only in the inner ear or temporal bone. The inner-ear-specific biomarkers detected in peripheral blood included otolin-1, prestin, and matrilin-1. Various serum antibodies correlated with inner ear diseases (e.g., anti-type II collagen, antinuclear antibodies, antibodies against cytomegalovirus). Further studies are advised to elucidate the clinical significance and diagnostic or prognostic usage of peripheral biomarkers for inner ear disorders, filling in the literature gaps with biomarkers pertinent to the otology clinical practice and integrating functional and molecular biomarkers. These may be the building blocks toward a well-structured guideline for diagnosing and managing some audio-vestibular disorders.

show abstract

“…The authors concluded that this protein can be used as a serum biomarker for BPPV to diagnose and assess therapeutic prognosis. Recently, Doğan et al 12 studied the relationship between serum otolin-1 and acoustic trauma during mastoidectomy. The authors found raised levels of serum otolin-1 in the patients who had undergone operations, which correlated positively with the duration of bone drilling.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10][11] Other inner-ear disorders that are being investigated with regard to the usefulness of inner-ear proteins as serum biomarkers include sudden sensorineural hearing loss, acoustic trauma and ototoxicity. 5,12,13 Parham et al 5 found that one third of their patients with BPPV had serum otolin-1 values above the control group. However, the patients in the study by Parham et al 5 had their most recent episode of BPPV up to two years before the serum marker sampling.…”

Section: Introductionmentioning

confidence: 97%

Serum otolin-1 as a biomarker for benign paroxysmal positional vertigo: a case-control study

et al. 2021

View full text Add to dashboard Cite

Objectives This study aimed to evaluate serum otolin-1 levels in patients with benign paroxysmal positional vertigo and to compare these levels with healthy individuals. Method This was a case-control study. After obtaining institutional ethical committee clearance, the serum level of otolin-1 was calculated in adult individuals (18–75 years old) who were divided into group 1 (patients presenting with benign paroxysmal positional vertigo) and group 2 (healthy patients without benign paroxysmal positional vertigo as the control group). Data analysis was carried out to compare the serum levels in the cases and controls. A p-value less than 0.05 was considered significant. Results A total of 70 age-matched individuals (cases, n = 40; controls, n = 30) were included in the study. The mean serum level of otolin-1 was 636.8 pg/ml (range, 259–981 pg/ml) in the group of patients with benign paroxysmal positional vertigo and 236.2 pg/ml (range, 189–370 pg/ml) in the control group. The difference was statistically significant (p = 0.0000). Conclusion The serum levels of otolin-1 in patients with benign paroxysmal positional vertigo are significantly higher compared with individuals without benign paroxysmal positional vertigo.

show abstract

Otolin-1, as a Potential Marker for Inner Ear Trauma after Mastoidectomy

Cited by 14 publications

References 16 publications

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Increased Otolin-1 in Serum as a Potential Biomarker for Idiopathic Benign Paroxysmal Positional Vertigo Episodes

Biomarkers for Inner Ear Disorders: Scoping Review on the Role of Biomarkers in Hearing and Balance Disorders

Serum otolin-1 as a biomarker for benign paroxysmal positional vertigo: a case-control study

Contact Info

Product

Resources

About