Ototoxicity of Orally Administered Neomycin: Report of a Case

Hypolipaemic drugs and coronary heart disease

“…Despite these properties, which are particularly useful in treating type Ila, the compound has not achieved widespread use. This could be related to its major side effect of audio toxicity (Gibson, 1967;Greenwood, 1959;Halpern and Heller, 1961;Greenberg and Momary, 1965;King, 1962). Neomycin, if absorbed in quantity, can cause permanent deafness with oral treatment (several cases have been reported).…”

Neomycin ototoxicity

“…It has also been seen after oral usage, although it usually has occurred in patients who have had concomitant gastrointestinal inflammation or renal impairment. [15][16][17][18][19][20][21][22][23] The following two cases demonstrate that ototoxicity can occur with administration of oral neomycin even if gastrointestinal and renal functions are not impaired. Early recognition of ototoxicity with neo-mycin is important because cessation of therapy may not only prevent further hearing loss but may allow partial or total recovery of the ototoxic insult.…”