Our 20-Year Institutional Experience with Surgical Approach for Breast Hamartomas

Türkyılmaz, Zeliha; Aydın, Tahacan; Yılmaz, Ravza; Önder, Semen; Özkurt, Enver; Tükenmez, Mustafa; Müslümanoğlu, Mahmut; Acunaş, Gülden; İğci, Abdullah; Özmen, Vahit; Dinçağ, Ahmet; Cabıoğlu, Neslihan

doi:10.5152/ejbh.2019.4624

Cited by 9 publications

(8 citation statements)

References 22 publications

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“…Bleeding volume in divided groups Excision rate in divided groups scar, was found in one case, which was present as well in the study of Türkyılmaz(9). Microcalcifications suggested a certain probability of potential malignancy(15).…”

supporting

confidence: 52%

“…been reported (6)(7)(8)(9). Additionally, recurrence was also an uncommon incident, about 8% in all cases (10).…”

Section: Original Articlementioning

confidence: 88%

“…Mammary hamartomas were considered rare with a low incidence in previous studies (1,9), mostly diagnosed in mammography and demonstrated by pathology. In US images, mammary hamartomas were called "breast within a breast" for their normal structures.…”

Section: Discussionmentioning

confidence: 99%

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Mammary hamartoma: is ultrasound-guided vacuum-assisted breast biopsy sufficient for its treatment?

Zhang

Liu

et al. 2020

Gland Surg

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Background: Mammary hamartomas were mostly benign tumors with rare rate of recurrence and malignant transformation. Ultrasound (US)-guided vacuum-assisted breast biopsy (VABB) has been reported sufficiently safe in treating many breast benign tumors but remained undefined in mammary hamartoma for its usual underdiagnosis in US. Thus, this study aims to evaluate the efficiency of US-guided VABB in treating mammary hamartomas.Methods: From May 2015 to March 2019, 3,388 lesions of 2,534 patients underwent percutaneous USguided VABB, among which 31 mammary hamartomas proved by pathology were included in this study.Patients were followed up by US three, six and twelve months later, then at 1-year intervals. Lesions were classified to analyze the possible factors associated with excision rate, bleeding volume and complications.Results: Of the 31 patients, recurrence was seen in 1 case in 1 year after the procedure and complete excision rate was 96.8% (30/31). The bleeding volume ranged from 1 to 15 mL (mean number ± standard deviation, 6.5±3.4 mL) and significant statistical differences were detected in patient age and the largest diameter of lesions. The main complications included pain (22.6%), hematomas (9.7%) and ecchymosis (3.2%).Conclusions: US-guided VABB ensures an outstanding complete excision rate and provides an alternative solution to treat mammary hamartomas.

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supporting

confidence: 52%

“…been reported (6)(7)(8)(9). Additionally, recurrence was also an uncommon incident, about 8% in all cases (10).…”

Section: Original Articlementioning

confidence: 88%

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Mammary hamartoma: is ultrasound-guided vacuum-assisted breast biopsy sufficient for its treatment?

Zhang

Liu

et al. 2020

Gland Surg

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“…16,17 In our study, the median age was 40 years, which is comparable to the literature. 5,18,19 Clinically, breast hamartomas are usually diagnosed during routine screening or because they are symptomatic (painless soft to firm lumps 5,11,13,20 and rarely painful 19 ). They are more often single, but cases of multiple hamartomas have been described, 13,21,22 as in two of our 45 patients.…”

Section: Discussionmentioning

confidence: 99%

Breast hamartoma: reassessment of an under‐recognised breast lesion

Alran

Chamming’s²,

Auriol-Leizagoyen³

et al. 2021

Histopathology

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Breast hamartoma: reassessment of an under-recognised breast lesionAims: Breast hamartomas are an under-recognised lesion because they lack a distinctive microscopic appearance. Microscopic diagnosis can often conclude 'no significant lesion' or 'normal breast tissue', leading to repeated biopsies and diagnostic delay. We describe the histological, immunohistochemical and radiological features of breast hamartomas with the aim of identifying specific signs to facilitate their diagnosis and to differentiate them from normal breast and fibroepithelial lesions. Methods and results: Forty-seven breast hamartomas were reassessed (histological diagnosis and imaging features). An immunohistochemical study [oestrogen receptor (ER), progesterone receptor (PR), CD34, high-mobility group A2 (HMGA2)] was performed. On breast imaging, hamartomas most often presented as probably benign solid masses with circumscribed margins and variable densities. Histologically, breast hamartomas resembled normal breast, although their stromal component was predominant, separating randomly scattered epithelial elements with areas of pure collagenous stroma. Pseudoangiomatous stromal hyperplasia (PASH) was present in 93.6% of cases and CD34 antibody highlighted intralobular, perilobular and interlobular distribution of CD34-positive fibroblasts. By comparison, CD34 was mainly expressed in the intralobular normal breast tissue stroma. Hamartoma stromal cells expressed HMGA2, ER and PR in 79%, 66% and 76.3% of our cases, respectively, compared to 7.7%, 23% and 19% in normal breast tissue, respectively (P < 0.0001; P = 0.0005; P < 0.0001). Conclusions: After ascertaining that core needle biopsy is effectively intralesional, breast hamartomas can be diagnosed with confidence by taking into account the presence of stromal changes, PASH, interlobular distribution of CD34-positive fibroblasts, HMGA2 and hormonal receptor stromal expression.

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“…Breast hamartoma was first defined as "hamartoma" in 1971 by Arrigoni et al (3) and was included in the World Health Organization classification in 1981 (2). Different tissues such as milk ducts, lobules, adipose and fibrous tissue, smooth muscle, and hyaline cartilage are present in breast hamartoma (4). A breast hamartoma is an extremely rare, benign, and slow-growing breast lesion that occurs more commonly in women than men and in the perimenopausal period than other ages.…”

Section: Introductionmentioning

confidence: 99%

Breast Hamartoma: Clinical, Radiological, and Histopathological Evaluation

Tazeoğlu¹,

Dağ²,

Arslan³

et al. 2021

EJBH

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Objective: Breast hamartomas are rare, benign, and slow-growing breast tumors that can be definitively diagnosed by combining the results of clinical, radiological, and histopathological examination. This study aimed to evaluate the clinical, radiological, and histopathological features of hamartomas and summarize our clinical approach to hamartomas. Materials and Methods:Patients diagnosed with breast hamartoma between 2010 and 2020 in our clinic were retrospectively analyzed. Demographic information, clinical examination, radiological findings, histopathological features, changes during follow-up, and follow-up data were obtained and analyzed.Results: Of the 1,429 patients operated on in our clinic for benign breast diseases between January 2010 and March 2020, 39 (2.7%) were diagnosed with breast hamartomas with histopathological examination. All patients were women with a median age of 37 (19-62) years. Most of the patients (64%) were in the premenopausal period. Radiological examinations were conducted using mammography (66%), breast ultrasonography (100%), and breast magnetic resonance imaging (48%). Biopsy was performed in 14 preoperative patients, and nine (64%) patients were diagnosed with hamartoma. All patients were operated on; 37 patients underwent a lumpectomy, and two had a mastectomy. No patients had hamartoma recurrence during an average follow-up period of 39 months. Conclusion:Hamartomas are similar to other benign breast pathologies. Definitive diagnosis can be achieved by combining the results of clinical, radiological, and histopathological examination. Given its similar composition to normal breast tissue, hamartoma has a low rate of malignancy. Definitive diagnosis and appropriate surgical treatment are required.

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Our 20-Year Institutional Experience with Surgical Approach for Breast Hamartomas

Cited by 9 publications

References 22 publications

Mammary hamartoma: is ultrasound-guided vacuum-assisted breast biopsy sufficient for its treatment?

Mammary hamartoma: is ultrasound-guided vacuum-assisted breast biopsy sufficient for its treatment?

Breast hamartoma: reassessment of an under‐recognised breast lesion

Breast Hamartoma: Clinical, Radiological, and Histopathological Evaluation

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