Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature

Abstract

<jats:title>Abstract</jats:title><jats:p>Hereditary spherocytosis (HS) and Chronic myelocytic leukemia (CML) are both life threatening hemotologic diseases. They are rarely seen to occur simultaneously in one individual patient. Here we demonstrate a case of HS associated with CML in this study. The patient is a young female, diagnosed with HS in 2005, and was given partial embolization of the splenic artery. She got significant remission after the procedure. In 2008, she was found abnormal in blood routine test, after bone marrow routine, chromosome and fusion gene tests, she was diagnosed with CML (chronic phase). She did not receive regular treatment until 3 months prior, and is currently being treated with Dasatimib. She achieved hematological remission, but had no significant improvement in chromosome and fusion gene figures. Due to her severe condition of hemolysis, a splenectomy or an allogeneic hematopoietic stem cell transplantation is considered.</jats:p>

Long-term follow-up after surgical management of laryngeal malignant pleomorphic sarcoma ‒ a case report

“…43 cases of laryngeal pleomorphic sarcoma of the larynx have been described in literature since 1972. 3 In men; laryngeal pleomorphic sarcoma is typically found in the glottic area. In contrast, in women in the subglottic region.…”

“…In addition, these neoplasms' anatomic and pathophysiologic heterogeneity demands variable and multifactorial considerations for effective management. 1 , 2 , 3 …”