One of the best evolution in technology breakthroughs is the Unmanned Aerial Vehicle (UAV). This aerial system is able to perform the mission in an agile environment and can reach the hard areas to perform the tasks autonomously. UAVs can be used in post-disaster situations to estimate damages, to monitor and to respond to the victims. The Ground Control Station can also provide emergency messages and ad-hoc communication to the Mobile Users of the disaster-stricken community using this network. A wireless network can also extend its communication range using UAV as a relay. Major requirements from such networks are robustness, scalability, energy efficiency and reliability. In general, UAVs are easy to deploy, have Line of Sight options and are flexible in nature. However, their 3D mobility, energy constraints, and deployment environment introduce many challenges. This paper provides a discussion of basic UAV based multi-hop relay network architecture and analyses their benefits, applications, and tradeoffs. Key design considerations and challenges are investigated finding fundamental issues and potential research directions to exploit them. Finally, analytical tools and frameworks for performance optimizations are presented.