2010
DOI: 10.1016/j.ijrobp.2009.03.001
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Outcome After Conservative Surgery and Breast Irradiation in 5,717 Patients With Breast Cancer: Implications for Supraclavicular Nodal Irradiation

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Cited by 24 publications
(10 citation statements)
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“…The risk of SR may be dependent on patient characteristics and primary treatment. Although our study did not aim at identifying risk factors for supraclavicular failure, it appears from the patient characteristics at primary diagnosis that a n expectedly large fraction of the study group presented with the high-risk parameters of axillary lymph node positive disease and high tumour malignancy grade as compared to the general patient population [6], in agreement with previous findings [9]. The median time to recurrence of 27 months did not differ significantly from other reports on locoregional recurrence [1,2].…”
Section: Discussionsupporting
confidence: 88%
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“…The risk of SR may be dependent on patient characteristics and primary treatment. Although our study did not aim at identifying risk factors for supraclavicular failure, it appears from the patient characteristics at primary diagnosis that a n expectedly large fraction of the study group presented with the high-risk parameters of axillary lymph node positive disease and high tumour malignancy grade as compared to the general patient population [6], in agreement with previous findings [9]. The median time to recurrence of 27 months did not differ significantly from other reports on locoregional recurrence [1,2].…”
Section: Discussionsupporting
confidence: 88%
“…Basically, the risk of SR is low [7][8][9], as also indicated by the frequency reported among patients entered into the DBCG adjuvant treatment database of only 1% among unselected consecutive patients treated for early breast cancer.…”
Section: Discussionmentioning
confidence: 99%
“…However, little mature evidence exists regarding this issue for those patients who underwent breast-conserving surgery. Nonetheless, it is established that patients with a considerable number of positive nodes have an increased risk of regional nodal metastasis [19][20][21], and it is reported that regional nodal irradiation improves loco-regional control [20,22,23].…”
Section: Recommendationmentioning
confidence: 99%
“…In patients who underwent breast-conserving surgery, the rates of supraclavicular lymph node metastases and internal mammary node metastases are reported to be 0-8.7 and 0-2 %, respectively [19][20][21]28]. The MA.20 study reported at ASCO in 2011 is one of the few RCTs investigating regional nodal irradiation for patients after breast-conserving surgery.…”
Section: Recommendationmentioning
confidence: 99%
“…Thus, several authors do not recommend prophylactic irradiation of the periclavicular fossa [17,29,30,34,48]. But according to a recent phase III study with 1,832 patients and 85% with 1-3 pN+, there was a statistically significant decrease in the rate of locoregional failure (LRF) and an increase in DFS for patients with locoregional RT [46].…”
Section: Periclavicular Irradiationmentioning
confidence: 99%