Outcome and Histopathologic Regression in Oral Squamous Cell Carcinoma after Preoperative Radiochemotherapy

Abstract

Preoperative radiochemotherapy with cisplatin/carboplatin followed by radical surgery attains favorable long-term survival rates. This applies especially to cases with complete histological tumor regression after radiochemotherapy, which can be assumed for one of five patients.

Combined-modality treatment in advanced oral squamous cell carcinoma

“…Our results indicate that primary surgery followed by adjuvant radiochemotherapy is suboptimal for patients with a UICC stage IVb OSCC [31]. During the last 10 years, a few studies evaluating the effect of neoadjuvant RCT in OSCC have been published but none has addressed the issue of possible differences between patients of the UICC stages IVa and IVb [18,22,26,28,32,33].…”

Cystatin C – A Fast and Reliable Biomarker for Glomerular Filtration Rate in Head and Neck Cancer Patients

“…Already partial renal insufficiency frequently poses an obstacle to therapeutic decisions and may lead to accumulation of chemotherapeutic agents and their metabolites. The nephrotoxicity of cisplatin is dose-related, cumulative, and depends on the extent of diuresis and the preexisting renal dysfunction [10,21,[23][24][25][26]33]. Therefore, an accurate estimation of renal function is needed for safe and effective use of this chemotherapeutic agent to prohibit toxic side effects [2,33].…”

Effectiveness of postoperative radiotherapy in patients with small oral and oropharyngeal squamous cell carcinoma and concomitant ipsilateral singular cervical lymph node metastasis (pN1)

“…In advanced disease, radiotherapy along with surgery and often in combination with chemotherapy supports modern multimodality treatment [2,3,9,20,26]. The decision for or against additional irradiation is predominantly guided by postoperative findings like the TNM/ UICC stage, histological evaluation of the resection margins (R1/R2), or presence of risk factors [16,27].…”