Outcome and prognostic factors in breast sarcoma: A multicenter study from the rare cancer network

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

“…Adjuvant radiotherapy after surgery, according to Johnstone et al allows for better local control 19 , but without effect on overall survival as noted by Pandey et al 20 . In our group, 45% of patients were treated with adjuvant radiotherapythat is a higher ratio than reported in the literature, where cohorts were larger in overall size 21,22 . The role and efficacy of chemotherapy has not been established as the available body of data comes from small size samples, from which definite conclusions cannot be drawn 23,24 .…”

Primary fibrosarcoma of breast: a rare case presentation

“…On histopathological examination, breast sarcomas are Cellular pleomorphism, mitotic numbers, stromal atypical and infiltrating borders have been found to be main prognostic factors. 6,7,23 Mammography is nonspecific demonstrating nonspiculated dense mass without microcalcification. 21,24 On USG they appear as hyperechoic with no shadowing.…”

“…In comparison to wide local excision, mastectomy was considered gold standard but recent study conflict this comparison and considered both of them equivocal. 3,5,7,9,13 For smaller localized breast sarcomas most of them recommended wide excision with greater than 3 cm normal tissue margin. 28 But to reduce the risk of local recurrence, mastectomy may be considered for those whose tumors are too large.…”

“…31 Majority of studies did not find any benefit for adjuvant radiotherapy. 1,7,11,32 But McGowan et al and Johnstone et al demonstrated significant benefits for patients. 3,33 They recommended post-operative irradiation of at least 60 grays to whole tumor bed.…”

“…Some authors excluded cystosarcoma phylloids from their studies due to presence of epithelial components but others do not because of their similar clinical and surgical course. [1][2][3][5][6][7][8][9] Most publicized articles are limited to small retrospective reviews and case reports, making clinicopathological study difficult.…”