Outcome in dogs with surgically resected oral fibrosarcoma (1997–2008)<sup>*</sup>

Allstadt, Sara D.; Johns, ST; Ortega, J.; Zwingenberger, Allison L.; Kent, Michael S.; Hammond, Genevieve M.; Rodríguez, C. O.; Steffey, Michele A.; Skorupski, Katherine A

doi:10.1111/j.1476-5829.2011.00272.x

Cited by 41 publications

(62 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In one retrospective study of 29 dogs with oral fibrosarcoma, complete and incomplete margins were not defined, but 15 dogs had complete histologic excision and 11 dogs had incomplete histologic excision. Seven dogs were diagnosed with local tumour recurrence, and five of these dogs had incomplete histologic excision of their oral fibrosarcomas.…”

Section: Clinical Relevance Of Histologic Margins: Assessing the Riskmentioning

confidence: 99%

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Liptak¹

2019

Vet Comparative Oncology

View full text Add to dashboard Cite

There is no consensus on the definition of a complete histologic excision in veterinary oncology; many definitions have been used in various studies, but these have been arbitrarily selected with no apparent justification. The residual tumour classification scheme, where a complete histologic excision is defined as a histologic tumour‐free margin >0 mm, has been used for >40 years in human oncology by all of the major clinical staging organizations and is considered highly prognostic for the vast majority of malignant tumours in people. Because of the widespread use of the residual tumour classification scheme both clinically and in research studies, this standardized approach permits better communication between clinicians, an evidence‐based decision‐making process for adjuvant treatment options following surgical resection, minimizes exposing patients to unnecessary adjuvant treatments and a better ability to compare local tumour control for specific tumours between different studies. The adoption of the residual tumour classification scheme in veterinary oncology would likely achieve similar outcomes and minimize the prevalent confusion within the veterinary community, amongst both general practitioners and specialists, regarding the definition of what constitutes a complete histologic excision.

show abstract

Section: Clinical Relevance Of Histologic Margins: Assessing the Riskmentioning

confidence: 99%

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Liptak¹

2019

Vet Comparative Oncology

View full text Add to dashboard Cite

show abstract

“…Embora os maiores tempos de sobrevivência e controle locorregional, tenham sido obtidos com o uso combinado das modalidades cirúrgica e radioterápica (Frazier et al, 2012, Gardner et al, 2015, a dificuldade de acesso e custos ainda elevados com tratamento radioterápico, nos direcionou a um tratamento quimioterápico neoadjuvante e cirúrgico.…”

Section: Discussionunclassified

“…Embora o tempo de sobrevida livre da doença atual e follow-up seja apenas de 30 dias, e que ainda seja elevada a probabilidade de uma recidiva locorregional (Frazier et al, 2012), tumores rostrais da cavidade oral estão associados a um melhor prognóstico.…”

Section: Discussionunclassified

“…Embora a taxa de recidiva locorregional seja elevada (32%-57%), e a maior causa de óbito nesses pacientes (Frazier et al, 2012), um estudo de referência com tumores mesenquimais, observou que cães com margens cirúrgicas histologicamente incompletas foram 10,5 vezes mais propensos a desenvolver recidiva local do que cães com margens completas (Kuntz et al, 1997).…”

Section: Introductionunclassified

See 1 more Smart Citation

Fibrosarcoma oral de bajo grado histológico y elevada agresividad biológica: reporte de un caso

Vasconcellos

2018

Pubvet

View full text Add to dashboard Cite

RESUMO.O objetivo deste relato foi descrever a ocorrência de um fibrossarcoma em uma cadela da raça Golden Retriever, com 12 anos de idade, pesando 42 kg. O animal apresentou histórico clínico de aumento do volume do plano nasal. Ao exame específico da cavidade oral, foi encontrada uma massa aderida à porção rostral do maxilar, encapsulada, medindo cerca de 5 cm de diâmetro, que se estendia cranialmente ao plano nasal, causando sua obstrução. Foi realizada biópsia incisional e o diagnóstico realizado com base na avaliação histopatológica. O animal foi submetido à quimioterapia neoadjuvante citorredutora e maxilectomia rostral bilateral. Até o momento não foi observada recidiva locorregional ou doença metastática. No Brasil, ainda são escassos os relatos de literatura envolvendo cirurgias radicais ou reconstrutivas em tumores oronasais. Palavras chave: cães, tumor, neoplasias da cavidade oralOral fibrosarcoma of low histological grade and high biological aggressiveness: case report ABSTRACT. The objective of this report was to describe the occurrence of a fibrosarcoma in a 12-year-old golden retriever, weighing 42 kg. The animal presented a clinical history of increased nasal plane volume. At the specific examination of the oral cavity, a mass adhered to the rostral portion of the maxilla was found, encapsulated, measuring about 5 cm in diameter, which extended cranially to the nasal plane, causing its obstruction. An incisional biopsy was performed and the diagnosis was made based on the histopathological evaluation. The animal was submitted to neoadjuvant chemoradiotherapy and bilateral rostral maxilectomy. To date no locoregional recurrence or metastatic disease has been observed. In Brazil, reports of literature involving radical or reconstructive surgeries in oronasal tumors are still scarce. Keywords: dogs, tumor, oral cavity neoplasiasFibrosarcoma oral de bajo grado histológico y elevada agresividad biológica: reporte de un caso RESUMEN. El objetivo de este relato fue describir el caso de un fibrosarcoma en una perra de raza Golden Retriever, con 12 años de edad, pesando 42 kg. El animal presentó un historial clínico de aumento del volumen del plano nasal. En el examen específico de la cavidad oral, se encontró una masa adherida a la porción rostral del maxilar, encapsulada, midiendo cerca de 5 cm de diámetro, que se extendía cranealmente al plano nasal, causando su obstrucción. Se realizó biopsia incisional y el diagnóstico realizado con base en la evaluación histopatológica. El animal fue sometido a quimioterapia citorreductora y

show abstract

“…Survival times for dogs with fibrosarcoma treated with surgery range from 7 to 12.2 months. Adding adjuvant radiotherapy improved outcomes by an average of 743 days [68]. Radiotherapy of sarcoma in dogs resulted in survival times between 8 and 19.7 months [69–74], whereas the success of chemotherapy is limited [75].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua

Breuer¹,

Efferth

2014

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Artemisinin, a constituent of Artemisia annua L., is a well-known antimalarial drug. Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo. Herbal extracts of A.annua inhibit the growth of cancer cell lines. Here, we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma. The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A.annua. One cat and one dog with fibrosarcoma survived 40 and 37 months, respectively, without tumor relapse. Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months, respectively. A.annua was well tolerated without noticeable side effects. These four cases indicate that A.annua may be a promising herbal drug for cancer therapy.

show abstract

Outcome in dogs with surgically resected oral fibrosarcoma (1997–2008)^*

Cited by 41 publications

References 12 publications

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Fibrosarcoma oral de bajo grado histológico y elevada agresividad biológica: reporte de un caso

Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua

Contact Info

Product

Resources

About

Outcome in dogs with surgically resected oral fibrosarcoma (1997–2008)*

Cited by 41 publications

References 12 publications

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Fibrosarcoma oral de bajo grado histológico y elevada agresividad biológica: reporte de un caso

Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua

Contact Info

Product

Resources

About

Outcome in dogs with surgically resected oral fibrosarcoma (1997–2008)^*