Outcome of albendazole therapy in the management of hepatic hydatid disease

Bari, Shams ul; Naqash, Mohd Mubarik; Malik, Ajaz Ahmad

doi:10.18203/2320-6012.ijrms20162328

Cited by 3 publications

(1 citation statement)

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“…However, these steps were poorly performed in the 11 hospitals prior to training, which may have contributed to high recurrence rates. Albendazole may play a role in preventing recurrence after operation [29,30]. According to expert consensus in China, the recommended dosage is 10-15 mg/kg/day, 3-7 days preoperatively and 3-12 months postoperatively for open cyst operations [18].…”

Section: Discussionmentioning

confidence: 99%

An integrated surgical training program for hepatic cystic echinococcosis in Xinjiang of China

Zhang

Yang

et al. 2020

PLoS Negl Trop Dis

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Background Human cystic echinococcosis (CE) is one of the commonest zoonoses, and it is endemic in many parts of the world including China. Complications and recurrences after the surgical treatment of hepatic CE (HCE) incur a large personal, healthcare, and societal burden. There has been some progress in HCE prevention, diagnosis, and treatment, but there is no "one size fits all" approach, and surgery still remains the cornerstone of treatment for some cyst stages and locations or in areas with little knowledge or access to other treatment modalities. In 2009 we designed and implemented a program to improve surgical outcomes from HCE in Xinjiang province, China. Methodology/Principal findings A multimodal HCE training program was implemented in eleven primary hospitals in Xinjiang province, China, which provided education and training on HCE clinical knowledge and practice, the application of diagnostic and treatment options, and optimal surgery. The management of HCE cases was analyzed before and after program implementation. Contrast enhanced CT use, application of scoloicidal agents, removal of necrotic cyst wall remnants, appropriate perioperative drug use, and the use of optimal surgical approach increased after program implementation. Further, postoperative recurrences and residual cavity complications creased from 7.4% to 1.3% and 15.2% to 9.0% after program implementation, respectively. Conclusions/Significance Tis integrated surgical training program is useful for improving outcomes of patients with HCE and can be used in institutions in other endemic areas.

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Section: Discussionmentioning

confidence: 99%

An integrated surgical training program for hepatic cystic echinococcosis in Xinjiang of China

Zhang

Yang

et al. 2020

PLoS Negl Trop Dis

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The Current Protocols in the Management of Hepatic Hydatid Disease

2021

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Correction of Albendazole Dosage After Liver Echinococctomy

Shamsiev

Rakhmanov

2020

Russian Journal of Pediatric Surgery

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Purpose. To improve the quality of treatment of patients with liver echinococcosis by optimizing postoperative chemotherapy. Material and methods. 226 patients with liver echinococcosis were admitted to the surgical department of the 2nd Clinic of the Samarkand State Medical Institute in 2009-2017. Patients were divided into two groups. In 2009-2012, 112 (49.5%) patients were operated on and were included into a control group. In 2013-2017, 114 (50.5%) patients were followed -up and were included into a study group. In the control group, postoperative chemotherapy was made by the standard protocol. In the studied group, Albendazole dosage was corrected according to the initial functional state of the liver. Due to positive findings in the experimental group, Albendazole was used at the dosage 5 mg / kg / day in patients with verified chronic liver disease and if liver enzymes were elevated before surgery. Results. Adverse reactions of Albendazole chemotherapy, by clinical and laboratory parameters, could develop in 52.7% - due to the preparation toxic effect and concomitant chronic diffuse liver pathology- while under dose correction, this figure is reduced to 18.3%. Conclusion. The proposed dose correction in patients with signs of liver insufficiency normalizes biochemical parameters and reduces toxic manifestations during chemotherapy. Of these 144 patients, long-term observations revealed echinococcosis relapse in 6 (4.2%) patients.

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Outcome of albendazole therapy in the management of hepatic hydatid disease

Cited by 3 publications

References 12 publications

An integrated surgical training program for hepatic cystic echinococcosis in Xinjiang of China

An integrated surgical training program for hepatic cystic echinococcosis in Xinjiang of China

The Current Protocols in the Management of Hepatic Hydatid Disease

Correction of Albendazole Dosage After Liver Echinococctomy

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