Outcome Prediction in Primary Resected Retroperitoneal Soft Tissue Sarcoma: Histology-Specific Overall Survival and Disease-Free Survival Nomograms Built on Major Sarcoma Center Data Sets

Abstract

These nomograms accurately predict OS and DFS. They should be used for patient counseling in clinical practice and stratification in clinical trials.

Neoadjuvant chemotherapy in soft tissue sarcomas: latest evidence and clinical implications

“…21 The manual includes at least two major changes: specific staging for head and neck, limb and trunk, and retroperitoneal sarcomas, and inclusion of a nomogram for the prognostic assessment of patients with retroperitoneal sarcomas. 22 Defining T-stage categories according to size is now tailored for the different primary tumour sites. Head and neck sarcomas are classified as T1, T2, T3, and T4 when their size is 2 cm or less, 2-4 cm, and greater than 4cm, and involving adjacent structures.…”

“…However, this tool included histological entities, such as malignant fibrous histiocytoma, that are no longer included in World Health Organization sarcoma classification and all tumour sites. Since then, several nomograms have been developed, including histology-specific nomograms for liposarcomas 29 and synovial sarcomas, 30 site-specific nomograms for both extremity 31,32 and retroperitoneal sarcomas, 22,33,34 and also uterine leiomyosarcomas. 35 Among these nomograms, the 'Sarculator' (http://www.sarculator.com/) is a freely available online resource with embedded nomograms for retroperitoneal 22,36 and extremity 32 sarcomas.…”

Omics Profiling in Precision Oncology

“…Tumor of any size that invades the mediastinum, heart, great vessels, (26,27). In addition to hematoxylin and eosin (H&E) stained slides, pathologists also use immunohistochemistry (IHC) to detect the presence of proteins and to semi-quantify protein expression levels (28).…”

Practical Issues for Retroperitoneal Sarcoma

“…Nomograms have been developed and validated to more accurately predict postoperative survival based on these and other factors. 39 Well-differentiated liposarcomas have the most favorable outcome, whereas leiomyosarcomas, pleomorphic sarcoma/malignant fibrous histiocytoma, MPNST, and dedifferentiated liposarcomas exhibit the least favorable outcomes. 38 Other prognostic concerns include risks for locore-gional recurrence and metastasis.…”