Outcome reporting across randomized trials and observational studies evaluating treatments for twin–twin transfusion syndrome: systematic review

Perry, Helen; Duffy, James M N; Umadia, Ogochukwu Chantelle; Khalil, Asma

doi:10.1002/uog.19068

Cited by 37 publications

(43 citation statements)

References 134 publications

(132 reference statements)

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“…A protocol including explicitly defined objectives, study selection criteria, and data extraction methods was developed. The protocol was informed by other evaluations in pre‐eclampsia, endometriosis, obstetrics, and urogynecology . Ethical approval for this study was not required.…”

Section: Methodsmentioning

confidence: 99%

A systematic review on reporting outcomes and outcome measures in trials on synthetic mesh procedures for pelvic organ prolapse: Urgent action is needed to improve quality of research

Lourenço¹,

Pergialiotis

Duffy

et al. 2018

Neurourology and Urodynamics

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The use of synthetic mesh in pelvic organ prolapse surgery is being closely scrutinized because of serious concerns regarding life‐changing complications such as erosion, pain, infection, bleeding, dyspareunia, organ perforation, and urinary problems. Randomized trials and their syntheses in meta‐analysis offer a unique opportunity to assess efficacy and safety. However, outcomes and outcome measures need to be consistently selected, collected, and reported across randomized trials to be effectively combined in systematic reviews. Aims We evaluated outcome and outcome measure reporting across randomized controlled trials on surgical interventions using synthetic mesh for pelvic organ prolapse. Methods Systematic review of randomized controlled trials using synthetic mesh for the treatment of pelvic organ prolapse. The selected studies were evaluated using Jadad and MOMENT criteria. Outcomes and outcome measures were systematically identified and categorized. Results Seventy‐one randomized trials were included. Twenty‐four different types of mesh were identified. Included trials reported 110 different outcomes and 60 outcome measures. Erosion (40 trials, 78%), pain (29 trials, 56%), bleeding (31 trials, 61%), and dyspareunia (25 trials, 49%) were the most frequently reported outcomes. The longest follow up was 74 months. Conclusions Most randomized trials evaluating surgical interventions using synthetic mesh for pelvic organ prolapse failed to report on clinically important outcomes and to evaluate efficacy and safety over the medium‐ and long‐term. Developing and implementing a minimum data set, known as a core outcome set, in future vaginal prolapse trials could help address these issues.

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Section: Methodsmentioning

confidence: 99%

A systematic review on reporting outcomes and outcome measures in trials on synthetic mesh procedures for pelvic organ prolapse: Urgent action is needed to improve quality of research

Lourenço¹,

Pergialiotis

Duffy

et al. 2018

Neurourology and Urodynamics

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“…The introduction of fetoscopic laser treatment for TTTS has benefited women and their babies worldwide. Despite over 20 years of research on TTTS, the recent systematic review on outcome reporting across studies evaluating treatments for TTTS identified only six randomized controlled trials on this subject. Evidence remains scarce relating to the optimal surgical approach, prognostic factors of outcome before and after laser treatment, and use of laser in Stage‐I TTTS, triplet pregnancy or TTTS co‐existent with selective fetal growth restriction (sFGR).…”

Section: Characteristics Of 39 Studies Evaluating Interventions For Smentioning

confidence: 99%

“…We investigated systematically the variation in outcome reporting across studies evaluating interventions for sFGR in monochorionic diamniotic twin pregnancies, according to the methodology reported in the linked systematic review of outcome reporting in TTTS and the Cochrane Collaboration handbook, COMET initiative handbook and other core outcome sets in development. MEDLINE, EMBASE, CINAHL, http://clinicaltrials.gov and The Cochrane Library databases were searched electronically using a comprehensive search strategy (Appendix S1).…”

Section: Characteristics Of 39 Studies Evaluating Interventions For Smentioning

confidence: 99%

“…We observed important differences in the pattern of outcome reporting, particularly with regard to fetal outcomes, between the studies evaluated in this systematic review and those included in the review of TTTS studies. The review of TTTS studies identified fetal outcomes that were frequently reported, including recurrence of TTTS or development of TAPS.…”

Section: Characteristics Of 39 Studies Evaluating Interventions For Smentioning

confidence: 99%

See 1 more Smart Citation

Variation in outcome reporting across studies evaluating interventions for selective fetal growth restriction

Sileo

Duffy

Townsend

et al. 2019

Ultrasound in Obstet & Gyne

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The recent investigation of variation in outcome reporting in studies of twin-to-twin transfusion syndrome has highlighted the problem of variable and inconsistently defined outcome reporting in studies of twin-to-twin transfusion syndrome (TTTS).(1) Similar heterogeneity in outcome reporting has been identified across women's and newborn health including pre-eclampsia, childbirth trauma and endometriosis.(2-8) This article is protected by copyright. All rights reserved.

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“…Although previously the variation in outcome reporting has been investigated and confirmed in several areas relevant to obstetrics and gynaecology, no evaluation has been undertaken in childbirth trauma research …”

Section: Introductionmentioning

confidence: 99%

Do we need a core outcome set for childbirth perineal trauma research? A systematic review of outcome reporting in randomised trials evaluating the management of childbirth trauma

Pergialiotis

Durnea

Elfituri

et al. 2018

BJOG

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Outcome reporting across randomized trials and observational studies evaluating treatments for twin–twin transfusion syndrome: systematic review

Cited by 37 publications

References 134 publications

A systematic review on reporting outcomes and outcome measures in trials on synthetic mesh procedures for pelvic organ prolapse: Urgent action is needed to improve quality of research

A systematic review on reporting outcomes and outcome measures in trials on synthetic mesh procedures for pelvic organ prolapse: Urgent action is needed to improve quality of research

Variation in outcome reporting across studies evaluating interventions for selective fetal growth restriction

Do we need a core outcome set for childbirth perineal trauma research? A systematic review of outcome reporting in randomised trials evaluating the management of childbirth trauma

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