Outcomes after corrective surgery for congenital dextro-transposition of the great arteries using the arterial switch technique: a protocol for a scoping systematic review

Abstract

IntroductionDextro-transposition of the great arteries (d-TGA) is a life-threatening congenital health defect that requires rapid surgery. The most widely used approach is the arterial switch operation (ASO) developed by Jatene in the 1970s. The first set of children who received this intervention are now adults. The objective of this scoping review of the literature was to document the short-term (less than 1 year), medium-term (1–20 years) and long-term (more than 20 years) outcomes in children who underwent the ASO. Our primary income is survival, but we will explore other secondary surgical, cardiovascular, reproductive and quality-of-life outcomes.Methods and analysesUsing a systematic scoping review approach, we will conduct a systematic search of the published literature for experimental and observational studies published on children who received the ASO intervention for classic d-TGA. We will search MEDLINE, Excerpta Medica Database (EMBASE), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Literatura Latino Americana em Ciências da Saúde (LILACS) from 1973 (date of the first successful ASO) to February 2014. Identified articles will be screened in duplicate and full text for selected articles will be retrieved. Data extraction will be carried out in duplicate. Discrepancies will be resolved by consensus or by consulting a third author. Where possible, proportions will be pooled using the inverse variance method. Our findings will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analysis Of Observational studies in Epidemiology (MOOSE) guidelines.Ethics and disseminationThe results of this paper will be disseminated as peer-reviewed publications, at conferences and at clinical rounds. Our findings may answer important questions for surgeons who perform the ASO intervention and for clinicians who take care of patients after surgery and throughout their lifespans.Trial Registration numberProspero/CRD42014007590.

Outcomes after corrective surgery for congenital dextro-transposition of the arteries using the arterial switch technique: a scoping systematic review

“…This review was registered with the International prospective register of systematic reviews (PROSPERO), registration number CRD42014007590 [16]. The methods of this study are published elsewhere [16] but outlined here in brief.…”

“…This review was registered with the International prospective register of systematic reviews (PROSPERO), registration number CRD42014007590 [ 16 ]. The methods of this study are published elsewhere [ 16 ] but outlined here in brief. The review is reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) (see Appendix 6 ) [ 17 ].…”

“…In this review, we will provide information on survival and other outcomes after treatment with ASO as outlined in the protocol [16].…”

Comparative Outcomes of Primary Arterial Switch Operation for Transposition of Great Arteries within the First Month of Life

“…The optimal surgical plan for simple TGA is the arterial switch operation (ASO), which is commonly performed shortly after birth to prevent left ventricular (LV) deconditioning. 1 - 3 From a clinical point of view, the early diagnosis of TGA is vital to avoid the involution of the LV, which may contribute to the low cardiac output syndrome and LV failure. Assessments of the impact of the surgical time on early outcomes after the repair of TGA have not led to consensus.…”