Outcomes and predictive factors for pathological node-positive in radiographically pure-solid, small-sized lung adenocarcinoma

Kayata, Hiroyuki; Isaka, Mitsuhiro; Mizuno, Kiyomichi; Yasuura, Yoshiyuki; Kojima, Hideaki; Ohde, Yasuhisa

doi:10.1007/s11748-018-01059-2

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, radiologically determined solid-dominant NSCLCs represent more malignant potential, such as vessel invasiveness and lymph node metastasis, compared with GGO-dominant tumors [12]. Moreover, pure solid tumors are associated with worse survival outcomes compared with part-solid tumors, even if the tumors are less than 2 cm in size [13]. In addition, postoperative nodal involvement was pathologically found in approximately 16–26% of lung cancer patients with radiographically determined tumors smaller than 2 cm [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of segmentectomy versus lobectomy for radiologically pure solid or solid-dominant stage IA non-small cell lung cancer

Rao

et al. 2019

J Cardiothorac Surg

View full text Add to dashboard Cite

ObjectiveWhether segmentectomy can be used to treat radiologically determined pure solid or solid-dominant lung cancer remains controversial owing to the invasive pathologic characteristics of these tumors despite their small size. This meta-analysis compared the oncologic outcomes after lobectomy and segmentectomy regarding relapse-free survival (RFS) and overall survival (OS) in patients with radiologically determined pure solid or solid-dominant clinical stage IA non-small cell lung cancer (NSCLC).MethodsA literature search was performed in the MEDLINE, EMBASE, and Cochrane Central databases for information from the date of database inception to March 2019. Studies were selected according to predefined eligibility criteria. The hazard ratio (HR) and associated 95% confidence interval (CI) were extracted or calculated as the outcome measure for data combining.ResultsSeven eligible studies published between 2014 and 2018 enrolling 1428 patients were included in the current meta-analysis. Compared with lobectomy, segmentectomy had a significant benefit on the RFS of radiologically determined pure solid or solid-dominant clinical stage IA NSCLC patients (combined HR: 1.46; 95% CI, 1.05–2.03; P = 0.024) and there were no significant differences on the OS of these patients (HR: 1.52; 95% CI, 0.95–2.43; P = 0.08).ConclusionsSegmentectomy leads to lower survival than lobectomy for clinical stage IA NSCLC patients with radiologically determined pure solid or solid-dominant tumors. Moreover, applying lobectomy to clinical stage IA NSCLC patients with radiologically determined pure solid or solid-dominant tumors (≤2 cm) could lead to an even bigger survival advantage. However, there are some limitations in the present study, and more evidence is needed to support the conclusion.

show abstract

Section: Introductionmentioning

confidence: 99%

Meta-analysis of segmentectomy versus lobectomy for radiologically pure solid or solid-dominant stage IA non-small cell lung cancer

Rao

et al. 2019

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

“…This is because solid tumors are considered to be highly malignant in nature, unexpected LN metastasis is observed in approximately 16% to 26% of these patients, and accurately evaluating LNs during a limited resection is difficult. [6][7][8] Unfortunately, although systematic LND is standard treatment, some researchers reported that only 57.3% of patients had received systematic LN evaluation for lung cancer. 9 Pure GGO tumors pathologically appear as atypical adenomatous hyperplasia, ADC in situ, and minimally invasive ADC.…”

mentioning

confidence: 99%

Predictive Factors for Lymph Node Metastasis in Clinical Stage I Part-Solid Lung Adenocarcinoma

Lee

Jeon

Jung

et al. 2021

The Annals of Thoracic Surgery

View full text Add to dashboard Cite

A case of robotic right middle and lower bilobectomy due to hilar lymph node metastasis for lung metastasis that recurred 8 years after surgery for ampullary cancer

Mizutani

Tao

2022

The Journal of the Japanese Association for Chest Surgery

View full text Add to dashboard Cite

Outcomes and predictive factors for pathological node-positive in radiographically pure-solid, small-sized lung adenocarcinoma

Cited by 3 publications

References 29 publications

Meta-analysis of segmentectomy versus lobectomy for radiologically pure solid or solid-dominant stage IA non-small cell lung cancer

Meta-analysis of segmentectomy versus lobectomy for radiologically pure solid or solid-dominant stage IA non-small cell lung cancer

Predictive Factors for Lymph Node Metastasis in Clinical Stage I Part-Solid Lung Adenocarcinoma

A case of robotic right middle and lower bilobectomy due to hilar lymph node metastasis for lung metastasis that recurred 8 years after surgery for ampullary cancer

Contact Info

Product

Resources

About