“…Baseline clinical characteristics of interest were defined a priori based on established associations with favorable OS or objective imaging response; these characteristics included IMDC risk group, 11 presence of sarcomatoid histological characteristics, 12 receipt of CN, 13 and sites of metastasis. 14 , 15 , 16 , 17 Although age 18 , 19 and sex 20 have not been reported to interact with outcomes associated with contemporary therapies for mRCC, these variables were included in the analysis because they had not been examined as confounders in large routine-practice data sets. In the adjusted logistic regression analysis, only CN (odds ratio [OR], 1.59; 95% CI, 1.04-2.43; P = .03), deferred nephrectomy (OR, 3.04; 95% CI, 1.03-8.97; P = .04), lung metastases (OR, 1.49; 95% CI, 1.01-2.20; P = .04), and favorable vs poor IMDC risk group (OR, 1.93; 95% CI, 1.10-3.39; P = .02) were associated with objective imaging response in a statistically significant and clinically meaningful manner ( Figure 1 ).…”